Self-sacrificial MOFs for ultra-long controlled release of bisphosphonate anti-osteoporotic drugs
In this paper we report drug delivery systems that are based on phosphonate MOFs. These employ biologically-acceptable metal ions ( e.g. Ca 2+ and Mg 2+ ) and several anti-osteoporosis bisphosphonate drugs (etidronate, pamidronate, alendronate and neridronate), as the organic linkers. These material...
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| Veröffentlicht in: | Chemical communications (Cambridge, England) England), 2020-05, Vol.56 (38), p.5166-5169 |
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| creator | Vassaki, Maria Papathanasiou, Konstantinos E Hadjicharalambous, Chrystalleni Chandrinou, Daphne Turhanen, Petri Choquesillo-Lazarte, Duane Demadis, Konstantinos D |
| description | In this paper we report drug delivery systems that are based on phosphonate MOFs. These employ biologically-acceptable metal ions (
e.g.
Ca
2+
and Mg
2+
) and several anti-osteoporosis bisphosphonate drugs (etidronate, pamidronate, alendronate and neridronate), as the organic linkers. These materials have been synthesized, structurally characterized, and studied for the self-sacrificial release (by pH-driven dissolution) of the bisphosphonate active ingredient. They exhibit variable release rates and final % release, depending on the actual structure of the metal-bisphosphonate material. Their cytotoxicity profiles match those of the active ingredients.
Metal-bisphosphonates are self-sacrificial controlled delivery systems that achieve ultra-long release of anti-osteoporotic bisphosphonate drugs. |
| doi_str_mv | 10.1039/d0cc00439a |
| format | Article |
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e.g.
Ca
2+
and Mg
2+
) and several anti-osteoporosis bisphosphonate drugs (etidronate, pamidronate, alendronate and neridronate), as the organic linkers. These materials have been synthesized, structurally characterized, and studied for the self-sacrificial release (by pH-driven dissolution) of the bisphosphonate active ingredient. They exhibit variable release rates and final % release, depending on the actual structure of the metal-bisphosphonate material. Their cytotoxicity profiles match those of the active ingredients.
Metal-bisphosphonates are self-sacrificial controlled delivery systems that achieve ultra-long release of anti-osteoporotic bisphosphonate drugs.</description><identifier>ISSN: 1359-7345</identifier><identifier>EISSN: 1364-548X</identifier><identifier>DOI: 10.1039/d0cc00439a</identifier><identifier>PMID: 32255461</identifier><language>eng</language><publisher>England: Royal Society of Chemistry</publisher><subject>Animals ; Biomedical materials ; Bisphosphonates ; Bone Density Conservation Agents - chemical synthesis ; Bone Density Conservation Agents - chemistry ; Bone Density Conservation Agents - pharmacology ; Calcium ions ; Cell Survival - drug effects ; Controlled release ; Crystallography ; Delayed-Action Preparations ; Diphosphonates - chemical synthesis ; Diphosphonates - chemistry ; Diphosphonates - pharmacology ; Dose-Response Relationship, Drug ; Drug delivery systems ; Drug Liberation ; Etidronic acid ; Hydrogen-Ion Concentration ; Metal-organic frameworks ; Metal-Organic Frameworks - chemistry ; Mice ; NIH 3T3 Cells ; Optical Imaging ; Osteoporosis ; Osteoporosis - drug therapy ; Phosphonates ; Structural analysis ; Toxicity</subject><ispartof>Chemical communications (Cambridge, England), 2020-05, Vol.56 (38), p.5166-5169</ispartof><rights>Copyright Royal Society of Chemistry 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c399t-ca107c15d9b07c14db7ba7b875a4dfc46d9dc8b0f9493e5f6052c8f5a053916d3</citedby><cites>FETCH-LOGICAL-c399t-ca107c15d9b07c14db7ba7b875a4dfc46d9dc8b0f9493e5f6052c8f5a053916d3</cites><orcidid>0000-0002-0937-8769 ; 0000-0003-1147-5231 ; 0000-0003-3343-8212 ; 0000-0002-7077-8972 ; 0000-0002-7546-8906 ; 0000-0001-6830-974X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32255461$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Vassaki, Maria</creatorcontrib><creatorcontrib>Papathanasiou, Konstantinos E</creatorcontrib><creatorcontrib>Hadjicharalambous, Chrystalleni</creatorcontrib><creatorcontrib>Chandrinou, Daphne</creatorcontrib><creatorcontrib>Turhanen, Petri</creatorcontrib><creatorcontrib>Choquesillo-Lazarte, Duane</creatorcontrib><creatorcontrib>Demadis, Konstantinos D</creatorcontrib><title>Self-sacrificial MOFs for ultra-long controlled release of bisphosphonate anti-osteoporotic drugs</title><title>Chemical communications (Cambridge, England)</title><addtitle>Chem Commun (Camb)</addtitle><description>In this paper we report drug delivery systems that are based on phosphonate MOFs. These employ biologically-acceptable metal ions (
e.g.
Ca
2+
and Mg
2+
) and several anti-osteoporosis bisphosphonate drugs (etidronate, pamidronate, alendronate and neridronate), as the organic linkers. These materials have been synthesized, structurally characterized, and studied for the self-sacrificial release (by pH-driven dissolution) of the bisphosphonate active ingredient. They exhibit variable release rates and final % release, depending on the actual structure of the metal-bisphosphonate material. Their cytotoxicity profiles match those of the active ingredients.
Metal-bisphosphonates are self-sacrificial controlled delivery systems that achieve ultra-long release of anti-osteoporotic bisphosphonate drugs.</description><subject>Animals</subject><subject>Biomedical materials</subject><subject>Bisphosphonates</subject><subject>Bone Density Conservation Agents - chemical synthesis</subject><subject>Bone Density Conservation Agents - chemistry</subject><subject>Bone Density Conservation Agents - pharmacology</subject><subject>Calcium ions</subject><subject>Cell Survival - drug effects</subject><subject>Controlled release</subject><subject>Crystallography</subject><subject>Delayed-Action Preparations</subject><subject>Diphosphonates - chemical synthesis</subject><subject>Diphosphonates - chemistry</subject><subject>Diphosphonates - pharmacology</subject><subject>Dose-Response Relationship, Drug</subject><subject>Drug delivery systems</subject><subject>Drug Liberation</subject><subject>Etidronic acid</subject><subject>Hydrogen-Ion Concentration</subject><subject>Metal-organic frameworks</subject><subject>Metal-Organic Frameworks - chemistry</subject><subject>Mice</subject><subject>NIH 3T3 Cells</subject><subject>Optical Imaging</subject><subject>Osteoporosis</subject><subject>Osteoporosis - drug therapy</subject><subject>Phosphonates</subject><subject>Structural analysis</subject><subject>Toxicity</subject><issn>1359-7345</issn><issn>1364-548X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc9LwzAUx4MoTqcX70rEm1BNmqRtjqM6FSY7qOCtpPkxO7KmJunB_97OzXnzweM9-H74Pvg-AM4wusGI8FuFpESIEi72wBEmGU0YLd731zvjSU4oG4HjEJZoKMyKQzAiacoYzfAREC_amiQI6RvTyEZY-DyfBmich72NXiTWtQsoXRu9s1Yr6LXVImjoDKyb0H24dbciaija2CQuRO06511sJFS-X4QTcGCEDfp0O8fgbXr_Wj4ms_nDUzmZJZJwHhMpMMolZorX60lVndcir4ucCaqMpJniShY1MpxyopnJEEtlYZhAjHCcKTIGVxvfzrvPXodYLV3v2-FklVKEMcWIpgN1vaGkdyF4barONyvhvyqMqnWa1R0qy580JwN8sbXs65VWO_Q3vgE43wA-yJ36945Bv_xPrzplyDfcz4XY</recordid><startdate>20200511</startdate><enddate>20200511</enddate><creator>Vassaki, Maria</creator><creator>Papathanasiou, Konstantinos E</creator><creator>Hadjicharalambous, Chrystalleni</creator><creator>Chandrinou, Daphne</creator><creator>Turhanen, Petri</creator><creator>Choquesillo-Lazarte, Duane</creator><creator>Demadis, Konstantinos D</creator><general>Royal Society of Chemistry</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>L7M</scope><orcidid>https://orcid.org/0000-0002-0937-8769</orcidid><orcidid>https://orcid.org/0000-0003-1147-5231</orcidid><orcidid>https://orcid.org/0000-0003-3343-8212</orcidid><orcidid>https://orcid.org/0000-0002-7077-8972</orcidid><orcidid>https://orcid.org/0000-0002-7546-8906</orcidid><orcidid>https://orcid.org/0000-0001-6830-974X</orcidid></search><sort><creationdate>20200511</creationdate><title>Self-sacrificial MOFs for ultra-long controlled release of bisphosphonate anti-osteoporotic drugs</title><author>Vassaki, Maria ; Papathanasiou, Konstantinos E ; Hadjicharalambous, Chrystalleni ; Chandrinou, Daphne ; Turhanen, Petri ; Choquesillo-Lazarte, Duane ; Demadis, Konstantinos D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c399t-ca107c15d9b07c14db7ba7b875a4dfc46d9dc8b0f9493e5f6052c8f5a053916d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Animals</topic><topic>Biomedical materials</topic><topic>Bisphosphonates</topic><topic>Bone Density Conservation Agents - chemical synthesis</topic><topic>Bone Density Conservation Agents - chemistry</topic><topic>Bone Density Conservation Agents - pharmacology</topic><topic>Calcium ions</topic><topic>Cell Survival - drug effects</topic><topic>Controlled release</topic><topic>Crystallography</topic><topic>Delayed-Action Preparations</topic><topic>Diphosphonates - chemical synthesis</topic><topic>Diphosphonates - chemistry</topic><topic>Diphosphonates - pharmacology</topic><topic>Dose-Response Relationship, Drug</topic><topic>Drug delivery systems</topic><topic>Drug Liberation</topic><topic>Etidronic acid</topic><topic>Hydrogen-Ion Concentration</topic><topic>Metal-organic frameworks</topic><topic>Metal-Organic Frameworks - chemistry</topic><topic>Mice</topic><topic>NIH 3T3 Cells</topic><topic>Optical Imaging</topic><topic>Osteoporosis</topic><topic>Osteoporosis - drug therapy</topic><topic>Phosphonates</topic><topic>Structural analysis</topic><topic>Toxicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vassaki, Maria</creatorcontrib><creatorcontrib>Papathanasiou, Konstantinos E</creatorcontrib><creatorcontrib>Hadjicharalambous, Chrystalleni</creatorcontrib><creatorcontrib>Chandrinou, Daphne</creatorcontrib><creatorcontrib>Turhanen, Petri</creatorcontrib><creatorcontrib>Choquesillo-Lazarte, Duane</creatorcontrib><creatorcontrib>Demadis, Konstantinos D</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><jtitle>Chemical communications (Cambridge, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vassaki, Maria</au><au>Papathanasiou, Konstantinos E</au><au>Hadjicharalambous, Chrystalleni</au><au>Chandrinou, Daphne</au><au>Turhanen, Petri</au><au>Choquesillo-Lazarte, Duane</au><au>Demadis, Konstantinos D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Self-sacrificial MOFs for ultra-long controlled release of bisphosphonate anti-osteoporotic drugs</atitle><jtitle>Chemical communications (Cambridge, England)</jtitle><addtitle>Chem Commun (Camb)</addtitle><date>2020-05-11</date><risdate>2020</risdate><volume>56</volume><issue>38</issue><spage>5166</spage><epage>5169</epage><pages>5166-5169</pages><issn>1359-7345</issn><eissn>1364-548X</eissn><abstract>In this paper we report drug delivery systems that are based on phosphonate MOFs. These employ biologically-acceptable metal ions (
e.g.
Ca
2+
and Mg
2+
) and several anti-osteoporosis bisphosphonate drugs (etidronate, pamidronate, alendronate and neridronate), as the organic linkers. These materials have been synthesized, structurally characterized, and studied for the self-sacrificial release (by pH-driven dissolution) of the bisphosphonate active ingredient. They exhibit variable release rates and final % release, depending on the actual structure of the metal-bisphosphonate material. Their cytotoxicity profiles match those of the active ingredients.
Metal-bisphosphonates are self-sacrificial controlled delivery systems that achieve ultra-long release of anti-osteoporotic bisphosphonate drugs.</abstract><cop>England</cop><pub>Royal Society of Chemistry</pub><pmid>32255461</pmid><doi>10.1039/d0cc00439a</doi><tpages>4</tpages><orcidid>https://orcid.org/0000-0002-0937-8769</orcidid><orcidid>https://orcid.org/0000-0003-1147-5231</orcidid><orcidid>https://orcid.org/0000-0003-3343-8212</orcidid><orcidid>https://orcid.org/0000-0002-7077-8972</orcidid><orcidid>https://orcid.org/0000-0002-7546-8906</orcidid><orcidid>https://orcid.org/0000-0001-6830-974X</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Chemical communications (Cambridge, England), 2020-05, Vol.56 (38), p.5166-5169 |
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| language | eng |
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| source | MEDLINE; Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| subjects | Animals Biomedical materials Bisphosphonates Bone Density Conservation Agents - chemical synthesis Bone Density Conservation Agents - chemistry Bone Density Conservation Agents - pharmacology Calcium ions Cell Survival - drug effects Controlled release Crystallography Delayed-Action Preparations Diphosphonates - chemical synthesis Diphosphonates - chemistry Diphosphonates - pharmacology Dose-Response Relationship, Drug Drug delivery systems Drug Liberation Etidronic acid Hydrogen-Ion Concentration Metal-organic frameworks Metal-Organic Frameworks - chemistry Mice NIH 3T3 Cells Optical Imaging Osteoporosis Osteoporosis - drug therapy Phosphonates Structural analysis Toxicity |
| title | Self-sacrificial MOFs for ultra-long controlled release of bisphosphonate anti-osteoporotic drugs |
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