Oxygen and embryonic growth: the role of insulin-like growth factor signaling

•Oxygen controls embryonic growth by modifying Igf-system in vertebrates.•Hypoxia limits Igf-action via Hif-mediated igfbp1a/b overexpression.•Re-oxygenation after hypoxia induces growth spurt termed catch-up growth.•Igf-Mapk pathway and NCCs are keys for the re-oxygenation induced catch-up growth....

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Veröffentlicht in:	General and comparative endocrinology 2020-08, Vol.294, p.113473, Article 113473
1. Verfasser:	Kamei, Hiroyasu
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Catch-up growth Embryonic growth Endocrinology & Metabolism Growth restriction Hypoxia Hypoxia - metabolism Insulin-like growth factor (IGF) Life Sciences & Biomedicine Models, Biological Oxygen Oxygen - metabolism Re-oxygenation Science & Technology Signal Transduction Somatomedins - metabolism Zebrafish Zebrafish - embryology Zebrafish - metabolism Zoology
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