Enteropathy-associated T-cell Lymphoma (EATL) with intracranial metastasis : a rare and dismal condition

Enteropathy-associated T-cell lymphoma (EATL) is a rare type of gastrointestinal non-Hodgkin's Lymphoma. EATL with intracranial metastasis is even rarer. We report a case of EATL with intracranial metastasis. A 36-years old man presented with five weeks history of intractable diarrhea. Colonosc...

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Veröffentlicht in:	Acta gastro-enterologica belgica 2020-01, Vol.83 (1), p.77
Hauptverfasser:	Chuah, Y Y, Tashi, T, Lee, Y Y, Fu, T Y, Shih, C A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Colonoscopy Diarrhea Enteropathy-Associated T-Cell Lymphoma Gastrointestinal Neoplasms Humans Male Prognosis
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creator	Chuah, Y Y Tashi, T Lee, Y Y Fu, T Y Shih, C A
description	Enteropathy-associated T-cell lymphoma (EATL) is a rare type of gastrointestinal non-Hodgkin's Lymphoma. EATL with intracranial metastasis is even rarer. We report a case of EATL with intracranial metastasis. A 36-years old man presented with five weeks history of intractable diarrhea. Colonoscopy was normal, but abdominal computed tomography (CT) scan revealed mural thickening at duodenojejunal junction, and subsequent jejunofiberoscopy showed a circumferential ulceration at the jejunum. Histo-immunopathology confirmed the diagnosis of enteropathyassociated T-cell lymphoma (EATL) type II. His disease course proved to be aggressive and refractory to standard front-line chemotherapy, and eventually progressed through second-line salvage regimen with CNS and intracranial involvement. He died nine months after the initial diagnosis. EATL with brain metastasis is a very rare occurrence with dismal prognosis.
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EATL with intracranial metastasis is even rarer. We report a case of EATL with intracranial metastasis. A 36-years old man presented with five weeks history of intractable diarrhea. Colonoscopy was normal, but abdominal computed tomography (CT) scan revealed mural thickening at duodenojejunal junction, and subsequent jejunofiberoscopy showed a circumferential ulceration at the jejunum. Histo-immunopathology confirmed the diagnosis of enteropathyassociated T-cell lymphoma (EATL) type II. His disease course proved to be aggressive and refractory to standard front-line chemotherapy, and eventually progressed through second-line salvage regimen with CNS and intracranial involvement. He died nine months after the initial diagnosis. 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EATL with intracranial metastasis is even rarer. We report a case of EATL with intracranial metastasis. A 36-years old man presented with five weeks history of intractable diarrhea. Colonoscopy was normal, but abdominal computed tomography (CT) scan revealed mural thickening at duodenojejunal junction, and subsequent jejunofiberoscopy showed a circumferential ulceration at the jejunum. Histo-immunopathology confirmed the diagnosis of enteropathyassociated T-cell lymphoma (EATL) type II. His disease course proved to be aggressive and refractory to standard front-line chemotherapy, and eventually progressed through second-line salvage regimen with CNS and intracranial involvement. He died nine months after the initial diagnosis. 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subjects	Adult Colonoscopy Diarrhea Enteropathy-Associated T-Cell Lymphoma Gastrointestinal Neoplasms Humans Male Prognosis
title	Enteropathy-associated T-cell Lymphoma (EATL) with intracranial metastasis : a rare and dismal condition
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