Asteris Radix et Rhizoma suppresses testosterone-induced benign prostatic hyperplasia in rats by regulating apoptosis and inflammation
Asteris Radix et Rhizoma (AR) refers to the roots and rhizomes of Aster tataricus L., which is widely distributed throughout East Asia. AR has been consumed as a traditional medicine in Korea, Japan and China for the treatment of urologic symptoms. To date, however, the therapeutic effect of AR on b...
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| Veröffentlicht in: | Journal of ethnopharmacology 2020-06, Vol.255, p.112779, Article 112779 |
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| creator | Rho, Jinhyung Seo, Chang-Seob Park, Hee-Seon Jeong, Hye-Yun Moon, Og-Sung Seo, Young-Won Son, Hwa-Young Won, Young-Suk Kwun, Hyo-Jung |
| description | Asteris Radix et Rhizoma (AR) refers to the roots and rhizomes of Aster tataricus L., which is widely distributed throughout East Asia. AR has been consumed as a traditional medicine in Korea, Japan and China for the treatment of urologic symptoms. To date, however, the therapeutic effect of AR on benign prostatic hyperplasia (BPH) has not been investigated.
The present study evaluated the therapeutic effects of AR on a testosterone-induced BPH rats.
We induced BPH to rats by subcutaneous injections (s.c) of testosterone propionate (TP) daily for four weeks. Rats were also administered daily oral gavage of AR (150 mg/kg) or vehicle. After four weeks of induction, all animals were euthanized humanely and their prostate glands were removed, weighed and processed for further analysis, including histopathological examination, real-time PCR, terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assay and Western blot analysis.
Administration of AR to TP-induced BPH rats considerably reduced prostate weight and concentrations of serum testosterone and prostate dihydrotestosterone (DHT). Epithelial thickness and expression of proliferating cell nuclear antigen (PCNA) were markedly suppressed by AR-treatment in the rats. Furthermore, the expression of the B-cell lymphoma 2 (Bcl-2) were reduced and expression of the Bcl-2-associated X protein (Bax) increased, resulting in significant reduction in Bcl-2/Bax ratio. In addition, AR decreased the level of pro-inflammatory cytokines, including interleukin-1β (IL-1β), interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α). The expression of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) were reduced by AR treatment in a TP-induced BPH rat model.
AR alleviates BPH by promoting apoptosis and suppressing inflammation, indicating that AR may be used clinically to treat BPH accompanied by inflammation.
[Display omitted] |
| doi_str_mv | 10.1016/j.jep.2020.112779 |
| format | Article |
| fullrecord | <record><control><sourceid>pubmed_cross</sourceid><recordid>TN_cdi_pubmed_primary_32209388</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0378874119334841</els_id><sourcerecordid>32209388</sourcerecordid><originalsourceid>FETCH-LOGICAL-c353t-67efac1c06358251361f76cf76884fadecbb11b3cfcdddbf5a8da1135049c2ca3</originalsourceid><addsrcrecordid>eNqNkN9uFCEUh4mxsWv1Abwx3JtZ-TMzsPGq2ag1adKkqdeEgcOWzQ5DgFHXB_C5ZTu1l6YXBMj5fufAh9A7StaU0P7jfr2HuGaE1TtlQmxeoBWVgjWiE_wlWhEuZCNFS8_R65z3hBBBW_IKnXPGyIZLuUJ_LnOB5DO-1db_wlDw7b3_PY0a5znGBDlDxgVymU7cFKDxwc4GLB4g-F3AMdWKLt7g-2OEFA86e419wEmXjIcjTrCbDxUIO6zjFGujOk0HWxl30ONYS1N4g86cPmR4-7hfoO9fPt9tr5rrm6_ftpfXjeEdL00vwGlDDel5J1lHeU-d6E1dUrZOWzDDQOnAjTPW2sF1WlpNKe9IuzHMaH6B6NLX1GfnBE7F5EedjooSdXKq9qo6VSenanFaM--XTJyHEexT4p_ECnxYgJ8wTC4bD8HAE1atd6xlnawHwk60fD699eXBz3aaQ6nRT0sUqqIfHpJ6jFufwBRlJ_-ff_wFp8Os_A</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Asteris Radix et Rhizoma suppresses testosterone-induced benign prostatic hyperplasia in rats by regulating apoptosis and inflammation</title><source>MEDLINE</source><source>Web of Science - Science Citation Index Expanded - 2020<img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" /></source><source>Access via ScienceDirect (Elsevier)</source><creator>Rho, Jinhyung ; Seo, Chang-Seob ; Park, Hee-Seon ; Jeong, Hye-Yun ; Moon, Og-Sung ; Seo, Young-Won ; Son, Hwa-Young ; Won, Young-Suk ; Kwun, Hyo-Jung</creator><creatorcontrib>Rho, Jinhyung ; Seo, Chang-Seob ; Park, Hee-Seon ; Jeong, Hye-Yun ; Moon, Og-Sung ; Seo, Young-Won ; Son, Hwa-Young ; Won, Young-Suk ; Kwun, Hyo-Jung</creatorcontrib><description>Asteris Radix et Rhizoma (AR) refers to the roots and rhizomes of Aster tataricus L., which is widely distributed throughout East Asia. AR has been consumed as a traditional medicine in Korea, Japan and China for the treatment of urologic symptoms. To date, however, the therapeutic effect of AR on benign prostatic hyperplasia (BPH) has not been investigated.
The present study evaluated the therapeutic effects of AR on a testosterone-induced BPH rats.
We induced BPH to rats by subcutaneous injections (s.c) of testosterone propionate (TP) daily for four weeks. Rats were also administered daily oral gavage of AR (150 mg/kg) or vehicle. After four weeks of induction, all animals were euthanized humanely and their prostate glands were removed, weighed and processed for further analysis, including histopathological examination, real-time PCR, terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assay and Western blot analysis.
Administration of AR to TP-induced BPH rats considerably reduced prostate weight and concentrations of serum testosterone and prostate dihydrotestosterone (DHT). Epithelial thickness and expression of proliferating cell nuclear antigen (PCNA) were markedly suppressed by AR-treatment in the rats. Furthermore, the expression of the B-cell lymphoma 2 (Bcl-2) were reduced and expression of the Bcl-2-associated X protein (Bax) increased, resulting in significant reduction in Bcl-2/Bax ratio. In addition, AR decreased the level of pro-inflammatory cytokines, including interleukin-1β (IL-1β), interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α). The expression of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) were reduced by AR treatment in a TP-induced BPH rat model.
AR alleviates BPH by promoting apoptosis and suppressing inflammation, indicating that AR may be used clinically to treat BPH accompanied by inflammation.
[Display omitted]</description><identifier>ISSN: 0378-8741</identifier><identifier>EISSN: 1872-7573</identifier><identifier>DOI: 10.1016/j.jep.2020.112779</identifier><identifier>PMID: 32209388</identifier><language>eng</language><publisher>CLARE: Elsevier B.V</publisher><subject><![CDATA[Animals ; Anti-Inflammatory Agents - isolation & purification ; Anti-Inflammatory Agents - pharmacology ; Apoptosis ; Apoptosis - drug effects ; Apoptosis Regulatory Proteins - metabolism ; Aster Plant - chemistry ; Asteris radix et rhizoma ; Benign prostatic hyperplasia ; Cell Proliferation - drug effects ; Chemistry, Medicinal ; Cytokines - metabolism ; Disease Models, Animal ; Diuretic ; Inflammation ; Inflammation Mediators - metabolism ; Integrative & Complementary Medicine ; Life Sciences & Biomedicine ; Male ; Organ Size ; Pharmacology & Pharmacy ; Plant Extracts - isolation & purification ; Plant Extracts - pharmacology ; Plant Roots - chemistry ; Plant Sciences ; Prostate - drug effects ; Prostate - metabolism ; Prostate - pathology ; Prostatic Hyperplasia - chemically induced ; Prostatic Hyperplasia - metabolism ; Prostatic Hyperplasia - pathology ; Prostatic Hyperplasia - prevention & control ; Rats, Sprague-Dawley ; Rhizome - chemistry ; Science & Technology ; Testosterone Propionate]]></subject><ispartof>Journal of ethnopharmacology, 2020-06, Vol.255, p.112779, Article 112779</ispartof><rights>2020 Elsevier B.V.</rights><rights>Copyright © 2020 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>25</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000524258000028</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c353t-67efac1c06358251361f76cf76884fadecbb11b3cfcdddbf5a8da1135049c2ca3</citedby><cites>FETCH-LOGICAL-c353t-67efac1c06358251361f76cf76884fadecbb11b3cfcdddbf5a8da1135049c2ca3</cites><orcidid>0000-0003-1246-5959</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jep.2020.112779$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27928,27929,28252,45999</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32209388$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rho, Jinhyung</creatorcontrib><creatorcontrib>Seo, Chang-Seob</creatorcontrib><creatorcontrib>Park, Hee-Seon</creatorcontrib><creatorcontrib>Jeong, Hye-Yun</creatorcontrib><creatorcontrib>Moon, Og-Sung</creatorcontrib><creatorcontrib>Seo, Young-Won</creatorcontrib><creatorcontrib>Son, Hwa-Young</creatorcontrib><creatorcontrib>Won, Young-Suk</creatorcontrib><creatorcontrib>Kwun, Hyo-Jung</creatorcontrib><title>Asteris Radix et Rhizoma suppresses testosterone-induced benign prostatic hyperplasia in rats by regulating apoptosis and inflammation</title><title>Journal of ethnopharmacology</title><addtitle>J ETHNOPHARMACOL</addtitle><addtitle>J Ethnopharmacol</addtitle><description>Asteris Radix et Rhizoma (AR) refers to the roots and rhizomes of Aster tataricus L., which is widely distributed throughout East Asia. AR has been consumed as a traditional medicine in Korea, Japan and China for the treatment of urologic symptoms. To date, however, the therapeutic effect of AR on benign prostatic hyperplasia (BPH) has not been investigated.
The present study evaluated the therapeutic effects of AR on a testosterone-induced BPH rats.
We induced BPH to rats by subcutaneous injections (s.c) of testosterone propionate (TP) daily for four weeks. Rats were also administered daily oral gavage of AR (150 mg/kg) or vehicle. After four weeks of induction, all animals were euthanized humanely and their prostate glands were removed, weighed and processed for further analysis, including histopathological examination, real-time PCR, terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assay and Western blot analysis.
Administration of AR to TP-induced BPH rats considerably reduced prostate weight and concentrations of serum testosterone and prostate dihydrotestosterone (DHT). Epithelial thickness and expression of proliferating cell nuclear antigen (PCNA) were markedly suppressed by AR-treatment in the rats. Furthermore, the expression of the B-cell lymphoma 2 (Bcl-2) were reduced and expression of the Bcl-2-associated X protein (Bax) increased, resulting in significant reduction in Bcl-2/Bax ratio. In addition, AR decreased the level of pro-inflammatory cytokines, including interleukin-1β (IL-1β), interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α). The expression of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) were reduced by AR treatment in a TP-induced BPH rat model.
AR alleviates BPH by promoting apoptosis and suppressing inflammation, indicating that AR may be used clinically to treat BPH accompanied by inflammation.
[Display omitted]</description><subject>Animals</subject><subject>Anti-Inflammatory Agents - isolation & purification</subject><subject>Anti-Inflammatory Agents - pharmacology</subject><subject>Apoptosis</subject><subject>Apoptosis - drug effects</subject><subject>Apoptosis Regulatory Proteins - metabolism</subject><subject>Aster Plant - chemistry</subject><subject>Asteris radix et rhizoma</subject><subject>Benign prostatic hyperplasia</subject><subject>Cell Proliferation - drug effects</subject><subject>Chemistry, Medicinal</subject><subject>Cytokines - metabolism</subject><subject>Disease Models, Animal</subject><subject>Diuretic</subject><subject>Inflammation</subject><subject>Inflammation Mediators - metabolism</subject><subject>Integrative & Complementary Medicine</subject><subject>Life Sciences & Biomedicine</subject><subject>Male</subject><subject>Organ Size</subject><subject>Pharmacology & Pharmacy</subject><subject>Plant Extracts - isolation & purification</subject><subject>Plant Extracts - pharmacology</subject><subject>Plant Roots - chemistry</subject><subject>Plant Sciences</subject><subject>Prostate - drug effects</subject><subject>Prostate - metabolism</subject><subject>Prostate - pathology</subject><subject>Prostatic Hyperplasia - chemically induced</subject><subject>Prostatic Hyperplasia - metabolism</subject><subject>Prostatic Hyperplasia - pathology</subject><subject>Prostatic Hyperplasia - prevention & control</subject><subject>Rats, Sprague-Dawley</subject><subject>Rhizome - chemistry</subject><subject>Science & Technology</subject><subject>Testosterone Propionate</subject><issn>0378-8741</issn><issn>1872-7573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>AOWDO</sourceid><sourceid>EIF</sourceid><recordid>eNqNkN9uFCEUh4mxsWv1Abwx3JtZ-TMzsPGq2ag1adKkqdeEgcOWzQ5DgFHXB_C5ZTu1l6YXBMj5fufAh9A7StaU0P7jfr2HuGaE1TtlQmxeoBWVgjWiE_wlWhEuZCNFS8_R65z3hBBBW_IKnXPGyIZLuUJ_LnOB5DO-1db_wlDw7b3_PY0a5znGBDlDxgVymU7cFKDxwc4GLB4g-F3AMdWKLt7g-2OEFA86e419wEmXjIcjTrCbDxUIO6zjFGujOk0HWxl30ONYS1N4g86cPmR4-7hfoO9fPt9tr5rrm6_ftpfXjeEdL00vwGlDDel5J1lHeU-d6E1dUrZOWzDDQOnAjTPW2sF1WlpNKe9IuzHMaH6B6NLX1GfnBE7F5EedjooSdXKq9qo6VSenanFaM--XTJyHEexT4p_ECnxYgJ8wTC4bD8HAE1atd6xlnawHwk60fD699eXBz3aaQ6nRT0sUqqIfHpJ6jFufwBRlJ_-ff_wFp8Os_A</recordid><startdate>20200612</startdate><enddate>20200612</enddate><creator>Rho, Jinhyung</creator><creator>Seo, Chang-Seob</creator><creator>Park, Hee-Seon</creator><creator>Jeong, Hye-Yun</creator><creator>Moon, Og-Sung</creator><creator>Seo, Young-Won</creator><creator>Son, Hwa-Young</creator><creator>Won, Young-Suk</creator><creator>Kwun, Hyo-Jung</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>AOWDO</scope><scope>BLEPL</scope><scope>DTL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><orcidid>https://orcid.org/0000-0003-1246-5959</orcidid></search><sort><creationdate>20200612</creationdate><title>Asteris Radix et Rhizoma suppresses testosterone-induced benign prostatic hyperplasia in rats by regulating apoptosis and inflammation</title><author>Rho, Jinhyung ; Seo, Chang-Seob ; Park, Hee-Seon ; Jeong, Hye-Yun ; Moon, Og-Sung ; Seo, Young-Won ; Son, Hwa-Young ; Won, Young-Suk ; Kwun, Hyo-Jung</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c353t-67efac1c06358251361f76cf76884fadecbb11b3cfcdddbf5a8da1135049c2ca3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Animals</topic><topic>Anti-Inflammatory Agents - isolation & purification</topic><topic>Anti-Inflammatory Agents - pharmacology</topic><topic>Apoptosis</topic><topic>Apoptosis - drug effects</topic><topic>Apoptosis Regulatory Proteins - metabolism</topic><topic>Aster Plant - chemistry</topic><topic>Asteris radix et rhizoma</topic><topic>Benign prostatic hyperplasia</topic><topic>Cell Proliferation - drug effects</topic><topic>Chemistry, Medicinal</topic><topic>Cytokines - metabolism</topic><topic>Disease Models, Animal</topic><topic>Diuretic</topic><topic>Inflammation</topic><topic>Inflammation Mediators - metabolism</topic><topic>Integrative & Complementary Medicine</topic><topic>Life Sciences & Biomedicine</topic><topic>Male</topic><topic>Organ Size</topic><topic>Pharmacology & Pharmacy</topic><topic>Plant Extracts - isolation & purification</topic><topic>Plant Extracts - pharmacology</topic><topic>Plant Roots - chemistry</topic><topic>Plant Sciences</topic><topic>Prostate - drug effects</topic><topic>Prostate - metabolism</topic><topic>Prostate - pathology</topic><topic>Prostatic Hyperplasia - chemically induced</topic><topic>Prostatic Hyperplasia - metabolism</topic><topic>Prostatic Hyperplasia - pathology</topic><topic>Prostatic Hyperplasia - prevention & control</topic><topic>Rats, Sprague-Dawley</topic><topic>Rhizome - chemistry</topic><topic>Science & Technology</topic><topic>Testosterone Propionate</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rho, Jinhyung</creatorcontrib><creatorcontrib>Seo, Chang-Seob</creatorcontrib><creatorcontrib>Park, Hee-Seon</creatorcontrib><creatorcontrib>Jeong, Hye-Yun</creatorcontrib><creatorcontrib>Moon, Og-Sung</creatorcontrib><creatorcontrib>Seo, Young-Won</creatorcontrib><creatorcontrib>Son, Hwa-Young</creatorcontrib><creatorcontrib>Won, Young-Suk</creatorcontrib><creatorcontrib>Kwun, Hyo-Jung</creatorcontrib><collection>Web of Science - Science Citation Index Expanded - 2020</collection><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Journal of ethnopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rho, Jinhyung</au><au>Seo, Chang-Seob</au><au>Park, Hee-Seon</au><au>Jeong, Hye-Yun</au><au>Moon, Og-Sung</au><au>Seo, Young-Won</au><au>Son, Hwa-Young</au><au>Won, Young-Suk</au><au>Kwun, Hyo-Jung</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Asteris Radix et Rhizoma suppresses testosterone-induced benign prostatic hyperplasia in rats by regulating apoptosis and inflammation</atitle><jtitle>Journal of ethnopharmacology</jtitle><stitle>J ETHNOPHARMACOL</stitle><addtitle>J Ethnopharmacol</addtitle><date>2020-06-12</date><risdate>2020</risdate><volume>255</volume><spage>112779</spage><pages>112779-</pages><artnum>112779</artnum><issn>0378-8741</issn><eissn>1872-7573</eissn><abstract>Asteris Radix et Rhizoma (AR) refers to the roots and rhizomes of Aster tataricus L., which is widely distributed throughout East Asia. AR has been consumed as a traditional medicine in Korea, Japan and China for the treatment of urologic symptoms. To date, however, the therapeutic effect of AR on benign prostatic hyperplasia (BPH) has not been investigated.
The present study evaluated the therapeutic effects of AR on a testosterone-induced BPH rats.
We induced BPH to rats by subcutaneous injections (s.c) of testosterone propionate (TP) daily for four weeks. Rats were also administered daily oral gavage of AR (150 mg/kg) or vehicle. After four weeks of induction, all animals were euthanized humanely and their prostate glands were removed, weighed and processed for further analysis, including histopathological examination, real-time PCR, terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assay and Western blot analysis.
Administration of AR to TP-induced BPH rats considerably reduced prostate weight and concentrations of serum testosterone and prostate dihydrotestosterone (DHT). Epithelial thickness and expression of proliferating cell nuclear antigen (PCNA) were markedly suppressed by AR-treatment in the rats. Furthermore, the expression of the B-cell lymphoma 2 (Bcl-2) were reduced and expression of the Bcl-2-associated X protein (Bax) increased, resulting in significant reduction in Bcl-2/Bax ratio. In addition, AR decreased the level of pro-inflammatory cytokines, including interleukin-1β (IL-1β), interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α). The expression of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) were reduced by AR treatment in a TP-induced BPH rat model.
AR alleviates BPH by promoting apoptosis and suppressing inflammation, indicating that AR may be used clinically to treat BPH accompanied by inflammation.
[Display omitted]</abstract><cop>CLARE</cop><pub>Elsevier B.V</pub><pmid>32209388</pmid><doi>10.1016/j.jep.2020.112779</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0003-1246-5959</orcidid></addata></record> |
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| subjects | Animals Anti-Inflammatory Agents - isolation & purification Anti-Inflammatory Agents - pharmacology Apoptosis Apoptosis - drug effects Apoptosis Regulatory Proteins - metabolism Aster Plant - chemistry Asteris radix et rhizoma Benign prostatic hyperplasia Cell Proliferation - drug effects Chemistry, Medicinal Cytokines - metabolism Disease Models, Animal Diuretic Inflammation Inflammation Mediators - metabolism Integrative & Complementary Medicine Life Sciences & Biomedicine Male Organ Size Pharmacology & Pharmacy Plant Extracts - isolation & purification Plant Extracts - pharmacology Plant Roots - chemistry Plant Sciences Prostate - drug effects Prostate - metabolism Prostate - pathology Prostatic Hyperplasia - chemically induced Prostatic Hyperplasia - metabolism Prostatic Hyperplasia - pathology Prostatic Hyperplasia - prevention & control Rats, Sprague-Dawley Rhizome - chemistry Science & Technology Testosterone Propionate |
| title | Asteris Radix et Rhizoma suppresses testosterone-induced benign prostatic hyperplasia in rats by regulating apoptosis and inflammation |
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