Evaluation of bile salt hydrolase inhibitor efficacy for modulating host bile profile and physiology using a chicken model system

Gut microbial enzymes, bile salt hydrolases (BSHs) are the gateway enzymes for bile acid (BA) modification in the gut. This activity is a promising target for developing innovative non-antibiotic growth promoters to enhance animal production and health. Compelling evidence has shown that inhibition...

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Veröffentlicht in:	Scientific reports 2020-03, Vol.10 (1), p.4941, Article 4941
Hauptverfasser:	Geng, Wenjing, Long, Sarah L., Chang, Yun-Juan, Saxton, Arnold M., Joyce, Susan A., Lin, Jun
Format:	Artikel
Sprache:	eng
Schlagworte:	631/326/41 631/553/318 64 692/4020/2741 Acids Amidohydrolases - antagonists & inhibitors Animal growth Animal production Animals Antibiotics Astrophysics Bile Bile Acids and Salts - blood Bile Acids and Salts - metabolism Body weight Body weight gain Caffeic acid Chickens Digestive system Drug Discovery Enzyme Activation - drug effects Enzyme Inhibitors - pharmacology Enzymes Feed additives Gastrointestinal tract Gene Expression Profiling Gene Expression Regulation - drug effects Humanities and Social Sciences Hydrolase Ileum - drug effects Ileum - metabolism Inhibitors Intestinal microflora Intestine Juveniles Lipid metabolism Liver - drug effects Liver - metabolism Metabolic Engineering Metabolism Metabolomics multidisciplinary Multidisciplinary Sciences Physics Riboflavin Ribonucleic acid RNA Science Science & Technology Science & Technology - Other Topics Science (multidisciplinary)
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