In Vivo Allergen-Activated Eosinophils Promote Collagen I and Fibronectin Gene Expression in Airway Smooth Muscle Cells via TGF- β 1 Signaling Pathway in Asthma

Eosinophils infiltration and releasing TGF- 1 in the airways has been implicated in the pathogenesis of asthma, especially during acute episodes provoked by an allergen. TGF- 1 is a major mediator involved in pro-inflammatory responses and fibrotic tissue remodeling in asthma. We aimed to evaluate t...

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Veröffentlicht in:	International journal of molecular sciences 2020-03, Vol.21 (5)
Hauptverfasser:	Janulaityte, Ieva, Januskevicius, Andrius, Kalinauskaite-Zukauske, Virginija, Bajoriuniene, Ieva, Malakauskas, Kestutis
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Asthma - chemically induced Asthma - immunology Asthma - metabolism Asthma - pathology Bronchial Provocation Tests - adverse effects Case-Control Studies Collagen Type I - genetics Collagen Type I - metabolism Collagen Type I, alpha 1 Chain Eosinophils - drug effects Eosinophils - immunology Female Fibronectins - genetics Fibronectins - metabolism Gene Expression Regulation Humans Male Myocytes, Smooth Muscle - drug effects Myocytes, Smooth Muscle - immunology Respiratory System - drug effects Respiratory System - immunology Signal Transduction Transforming Growth Factor beta1 - genetics Transforming Growth Factor beta1 - metabolism Young Adult
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