Upregulation of PD-L1 Expression by Prostaglandin E 2 and the Enhancement of IFN-γ by Anti-PD-L1 Antibody Combined With a COX-2 Inhibitor in Mycoplasma bovis Infection

Bovine mycoplasmosis caused by results in pneumonia and mastitis in cattle. We previously demonstrated that the programmed death 1 (PD-1)/PD-ligand 1 (PD-L1) pathway is involved in immune dysfunction during infection and that prostaglandin E (PGE ) suppressed immune responses and upregulated PD-L1 e...

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Veröffentlicht in:	Frontiers in veterinary science 2020-02, Vol.7, p.12
Hauptverfasser:	Goto, Shinya, Konnai, Satoru, Hirano, Yuki, Kohara, Junko, Okagawa, Tomohiro, Maekawa, Naoya, Sajiki, Yamato, Watari, Kei, Minato, Erina, Kobayashi, Atsuhi, Gondaira, Satoshi, Higuchi, Hidetoshi, Koiwa, Masateru, Tajima, Motoshi, Taguchi, Eiji, Uemura, Ryoko, Yamada, Shinji, Kaneko, Mika K, Kato, Yukinari, Yamamoto, Keiichi, Toda, Mikihiro, Suzuki, Yasuhiko, Murata, Shiro, Ohashi, Kazuhiko
Format:	Artikel
Sprache:	eng
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