Multiple molecular targets mediated antioxidant activity, molecular docking, ADMET, QSAR and bioactivity studies of halo substituted urea derivatives of α-Methyl-l-DOPA

[Display omitted] •Firstly integrated α-Methyl-l-DOPA & halogenated phenyl rings to urea template.•Synthesized methyl DOPA ureas are proved as BBB graded neuroprotective antioxidants.•Molecular docking proved title compounds as multiple targets mediated antioxidants.•The presence of CH3 isosteri...

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Veröffentlicht in:Bioorganic chemistry 2020-04, Vol.97, p.103708, Article 103708
Hauptverfasser: Vadabingi, Nagalakshmamma, Avula, Vijaya Kumar Reddy, Zyryanov, Grigory V., Vallela, Swetha, Anireddy, Jaya Shree, Pasupuleti, Visweswara Rao, Mallepogu, Venkataswamy, Chamarthi, Naga Raju, Ponne, Venkata Chalapathi
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Sprache:eng
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