Effect of nanoscale bioactive glass with radial spherical particles on osteogenic differentiation of rat bone marrow mesenchymal stem cells
To validate the feasibility of two types of bioactive glass that contains spherical and radical spherical nano-sized particles in promoting bone repair, we hypothesize that radical spherical nano-sized particles have higher bone repair effectiveness than spherical one due to the physicochemical prop...
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| Veröffentlicht in: | Journal of materials science. Materials in medicine 2020-03, Vol.31 (3), p.29, Article 29 |
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| creator | Wang, Lili Yan, Jia Hu, Xiaokun Zhu, Xinchen Hu, Shuying Qian, Jun Zhang, Feimin Liu, Mei |
| description | To validate the feasibility of two types of bioactive glass that contains spherical and radical spherical nano-sized particles in promoting bone repair, we hypothesize that radical spherical nano-sized particles have higher bone repair effectiveness than spherical one due to the physicochemical properties. We rigorously compared the physicochemical properties and bioactivities of these two types of bioactive glass. Specifically, we measured the size, surface morphology, concentration of ionic-dissolution products, bioactivity, and biological effects of two groups of bioactive glass on rat bone marrow mesenchymal stem cells (rBMSCs) and evaluate their effect on proliferation and osteogenic differentiation of rBMSCs in vitro. We observed that spherical nano-bioactive glass (SNBG) was spherical with smooth boundary, while the radial spherical nano-bioactive glass (RSNBG) had radial pore on the surface of particle boundary. When the two materials were immersed in simulated body fluid for 24 h, RSNBG produced more and denser hydroxyapatite carbonate than SNBG. The concentration of Ca and Si ions in RSNBG 24 h extract is higher than that of SNBG, while the concentration of P ions is lower. Proliferation, alkaline phosphatase (ALP) activity, intracellular Ca ion concentrations defined as the number of mineralized nodules produced, and the expression of osteogenic genes were significantly higher in rBMSCs co-cultured with 50 µg/mL RSNBG than SNBG. Overall, these results validated our hypothesis that RSNBG can provide better benefit than SNBG for inducing proliferation and osteogenic differentiation in rBMSCs, in turn suggested the feasibility of this RSNBG in further studies and utilization toward the ends of improved bone repair effectiveness. |
| doi_str_mv | 10.1007/s10856-020-06368-8 |
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We rigorously compared the physicochemical properties and bioactivities of these two types of bioactive glass. Specifically, we measured the size, surface morphology, concentration of ionic-dissolution products, bioactivity, and biological effects of two groups of bioactive glass on rat bone marrow mesenchymal stem cells (rBMSCs) and evaluate their effect on proliferation and osteogenic differentiation of rBMSCs in vitro. We observed that spherical nano-bioactive glass (SNBG) was spherical with smooth boundary, while the radial spherical nano-bioactive glass (RSNBG) had radial pore on the surface of particle boundary. When the two materials were immersed in simulated body fluid for 24 h, RSNBG produced more and denser hydroxyapatite carbonate than SNBG. The concentration of Ca and Si ions in RSNBG 24 h extract is higher than that of SNBG, while the concentration of P ions is lower. Proliferation, alkaline phosphatase (ALP) activity, intracellular Ca ion concentrations defined as the number of mineralized nodules produced, and the expression of osteogenic genes were significantly higher in rBMSCs co-cultured with 50 µg/mL RSNBG than SNBG. Overall, these results validated our hypothesis that RSNBG can provide better benefit than SNBG for inducing proliferation and osteogenic differentiation in rBMSCs, in turn suggested the feasibility of this RSNBG in further studies and utilization toward the ends of improved bone repair effectiveness.</description><identifier>ISSN: 0957-4530</identifier><identifier>EISSN: 1573-4838</identifier><identifier>DOI: 10.1007/s10856-020-06368-8</identifier><identifier>PMID: 32140885</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Alkaline phosphatase ; Animals ; Biocompatible Materials - chemistry ; Bioglass ; Biological activity ; Biological effects ; Biomaterials ; Biomedical Engineering and Bioengineering ; Biomedical materials ; Body fluids ; Bone healing ; Bone marrow ; Bone Marrow Cells - drug effects ; Calcium - chemistry ; Calcium ions ; Cell Differentiation ; Cell Proliferation ; Cells, Cultured ; Ceramics ; Chemistry and Materials Science ; Composites ; Differentiation (biology) ; Engineering ; Engineering and Nano-engineering Approaches for Medical Devices ; Engineering, Biomedical ; Feasibility ; Gene expression ; Glass ; Glass - chemistry ; Hydroxyapatite ; In vitro methods and tests ; Ions ; Materials Science ; Materials Science, Biomaterials ; Mesenchymal stem cells ; Mesenchymal Stem Cells - drug effects ; Morphology ; Nanoparticles - chemistry ; Nanotechnology ; Natural Materials ; Nodules ; Osteogenesis - drug effects ; Particle Size ; Physicochemical properties ; Polymer Sciences ; Rats ; Rats, Sprague-Dawley ; Regenerative Medicine/Tissue Engineering ; Repair ; Science & Technology ; Smooth boundaries ; Stem cell transplantation ; Stem cells ; Surface Properties ; Surfaces and Interfaces ; Surgical implants ; Technology ; Thin Films ; Tissue Scaffolds - chemistry</subject><ispartof>Journal of materials science. Materials in medicine, 2020-03, Vol.31 (3), p.29, Article 29</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2020</rights><rights>Journal of Materials Science: Materials in Medicine is a copyright of Springer, (2020). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>8</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000519032100001</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c412t-a2b66f1e10f2fc9e78bc74d34b0de2055bcf53a3b1fbb67d55368709911846ba3</citedby><cites>FETCH-LOGICAL-c412t-a2b66f1e10f2fc9e78bc74d34b0de2055bcf53a3b1fbb67d55368709911846ba3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10856-020-06368-8$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10856-020-06368-8$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>315,782,786,27933,27934,28257,41497,42566,51328</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32140885$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Lili</creatorcontrib><creatorcontrib>Yan, Jia</creatorcontrib><creatorcontrib>Hu, Xiaokun</creatorcontrib><creatorcontrib>Zhu, Xinchen</creatorcontrib><creatorcontrib>Hu, Shuying</creatorcontrib><creatorcontrib>Qian, Jun</creatorcontrib><creatorcontrib>Zhang, Feimin</creatorcontrib><creatorcontrib>Liu, Mei</creatorcontrib><title>Effect of nanoscale bioactive glass with radial spherical particles on osteogenic differentiation of rat bone marrow mesenchymal stem cells</title><title>Journal of materials science. Materials in medicine</title><addtitle>J Mater Sci: Mater Med</addtitle><addtitle>J MATER SCI-MATER M</addtitle><addtitle>J Mater Sci Mater Med</addtitle><description>To validate the feasibility of two types of bioactive glass that contains spherical and radical spherical nano-sized particles in promoting bone repair, we hypothesize that radical spherical nano-sized particles have higher bone repair effectiveness than spherical one due to the physicochemical properties. We rigorously compared the physicochemical properties and bioactivities of these two types of bioactive glass. Specifically, we measured the size, surface morphology, concentration of ionic-dissolution products, bioactivity, and biological effects of two groups of bioactive glass on rat bone marrow mesenchymal stem cells (rBMSCs) and evaluate their effect on proliferation and osteogenic differentiation of rBMSCs in vitro. We observed that spherical nano-bioactive glass (SNBG) was spherical with smooth boundary, while the radial spherical nano-bioactive glass (RSNBG) had radial pore on the surface of particle boundary. When the two materials were immersed in simulated body fluid for 24 h, RSNBG produced more and denser hydroxyapatite carbonate than SNBG. The concentration of Ca and Si ions in RSNBG 24 h extract is higher than that of SNBG, while the concentration of P ions is lower. Proliferation, alkaline phosphatase (ALP) activity, intracellular Ca ion concentrations defined as the number of mineralized nodules produced, and the expression of osteogenic genes were significantly higher in rBMSCs co-cultured with 50 µg/mL RSNBG than SNBG. Overall, these results validated our hypothesis that RSNBG can provide better benefit than SNBG for inducing proliferation and osteogenic differentiation in rBMSCs, in turn suggested the feasibility of this RSNBG in further studies and utilization toward the ends of improved bone repair effectiveness.</description><subject>Alkaline phosphatase</subject><subject>Animals</subject><subject>Biocompatible Materials - chemistry</subject><subject>Bioglass</subject><subject>Biological activity</subject><subject>Biological effects</subject><subject>Biomaterials</subject><subject>Biomedical Engineering and Bioengineering</subject><subject>Biomedical materials</subject><subject>Body fluids</subject><subject>Bone healing</subject><subject>Bone marrow</subject><subject>Bone Marrow Cells - drug effects</subject><subject>Calcium - chemistry</subject><subject>Calcium ions</subject><subject>Cell Differentiation</subject><subject>Cell Proliferation</subject><subject>Cells, Cultured</subject><subject>Ceramics</subject><subject>Chemistry and Materials Science</subject><subject>Composites</subject><subject>Differentiation (biology)</subject><subject>Engineering</subject><subject>Engineering and Nano-engineering Approaches for Medical Devices</subject><subject>Engineering, Biomedical</subject><subject>Feasibility</subject><subject>Gene expression</subject><subject>Glass</subject><subject>Glass - chemistry</subject><subject>Hydroxyapatite</subject><subject>In vitro methods and tests</subject><subject>Ions</subject><subject>Materials Science</subject><subject>Materials Science, Biomaterials</subject><subject>Mesenchymal stem cells</subject><subject>Mesenchymal Stem Cells - drug effects</subject><subject>Morphology</subject><subject>Nanoparticles - chemistry</subject><subject>Nanotechnology</subject><subject>Natural Materials</subject><subject>Nodules</subject><subject>Osteogenesis - drug effects</subject><subject>Particle Size</subject><subject>Physicochemical properties</subject><subject>Polymer Sciences</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Regenerative Medicine/Tissue Engineering</subject><subject>Repair</subject><subject>Science & Technology</subject><subject>Smooth boundaries</subject><subject>Stem cell transplantation</subject><subject>Stem cells</subject><subject>Surface Properties</subject><subject>Surfaces and Interfaces</subject><subject>Surgical implants</subject><subject>Technology</subject><subject>Thin Films</subject><subject>Tissue Scaffolds - 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chemistry</topic><topic>Bioglass</topic><topic>Biological activity</topic><topic>Biological effects</topic><topic>Biomaterials</topic><topic>Biomedical Engineering and Bioengineering</topic><topic>Biomedical materials</topic><topic>Body fluids</topic><topic>Bone healing</topic><topic>Bone marrow</topic><topic>Bone Marrow Cells - drug effects</topic><topic>Calcium - chemistry</topic><topic>Calcium ions</topic><topic>Cell Differentiation</topic><topic>Cell Proliferation</topic><topic>Cells, Cultured</topic><topic>Ceramics</topic><topic>Chemistry and Materials Science</topic><topic>Composites</topic><topic>Differentiation (biology)</topic><topic>Engineering</topic><topic>Engineering and Nano-engineering Approaches for Medical Devices</topic><topic>Engineering, Biomedical</topic><topic>Feasibility</topic><topic>Gene expression</topic><topic>Glass</topic><topic>Glass - chemistry</topic><topic>Hydroxyapatite</topic><topic>In vitro methods and tests</topic><topic>Ions</topic><topic>Materials Science</topic><topic>Materials Science, Biomaterials</topic><topic>Mesenchymal stem cells</topic><topic>Mesenchymal Stem Cells - drug effects</topic><topic>Morphology</topic><topic>Nanoparticles - chemistry</topic><topic>Nanotechnology</topic><topic>Natural Materials</topic><topic>Nodules</topic><topic>Osteogenesis - drug effects</topic><topic>Particle Size</topic><topic>Physicochemical properties</topic><topic>Polymer Sciences</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Regenerative Medicine/Tissue Engineering</topic><topic>Repair</topic><topic>Science & Technology</topic><topic>Smooth boundaries</topic><topic>Stem cell transplantation</topic><topic>Stem cells</topic><topic>Surface Properties</topic><topic>Surfaces and Interfaces</topic><topic>Surgical implants</topic><topic>Technology</topic><topic>Thin Films</topic><topic>Tissue Scaffolds - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Lili</creatorcontrib><creatorcontrib>Yan, Jia</creatorcontrib><creatorcontrib>Hu, Xiaokun</creatorcontrib><creatorcontrib>Zhu, Xinchen</creatorcontrib><creatorcontrib>Hu, Shuying</creatorcontrib><creatorcontrib>Qian, Jun</creatorcontrib><creatorcontrib>Zhang, Feimin</creatorcontrib><creatorcontrib>Liu, Mei</creatorcontrib><collection>Web of Science - 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Materials in medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Lili</au><au>Yan, Jia</au><au>Hu, Xiaokun</au><au>Zhu, Xinchen</au><au>Hu, Shuying</au><au>Qian, Jun</au><au>Zhang, Feimin</au><au>Liu, Mei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of nanoscale bioactive glass with radial spherical particles on osteogenic differentiation of rat bone marrow mesenchymal stem cells</atitle><jtitle>Journal of materials science. Materials in medicine</jtitle><stitle>J Mater Sci: Mater Med</stitle><stitle>J MATER SCI-MATER M</stitle><addtitle>J Mater Sci Mater Med</addtitle><date>2020-03-05</date><risdate>2020</risdate><volume>31</volume><issue>3</issue><spage>29</spage><pages>29-</pages><artnum>29</artnum><issn>0957-4530</issn><eissn>1573-4838</eissn><abstract>To validate the feasibility of two types of bioactive glass that contains spherical and radical spherical nano-sized particles in promoting bone repair, we hypothesize that radical spherical nano-sized particles have higher bone repair effectiveness than spherical one due to the physicochemical properties. We rigorously compared the physicochemical properties and bioactivities of these two types of bioactive glass. Specifically, we measured the size, surface morphology, concentration of ionic-dissolution products, bioactivity, and biological effects of two groups of bioactive glass on rat bone marrow mesenchymal stem cells (rBMSCs) and evaluate their effect on proliferation and osteogenic differentiation of rBMSCs in vitro. We observed that spherical nano-bioactive glass (SNBG) was spherical with smooth boundary, while the radial spherical nano-bioactive glass (RSNBG) had radial pore on the surface of particle boundary. When the two materials were immersed in simulated body fluid for 24 h, RSNBG produced more and denser hydroxyapatite carbonate than SNBG. The concentration of Ca and Si ions in RSNBG 24 h extract is higher than that of SNBG, while the concentration of P ions is lower. Proliferation, alkaline phosphatase (ALP) activity, intracellular Ca ion concentrations defined as the number of mineralized nodules produced, and the expression of osteogenic genes were significantly higher in rBMSCs co-cultured with 50 µg/mL RSNBG than SNBG. Overall, these results validated our hypothesis that RSNBG can provide better benefit than SNBG for inducing proliferation and osteogenic differentiation in rBMSCs, in turn suggested the feasibility of this RSNBG in further studies and utilization toward the ends of improved bone repair effectiveness.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>32140885</pmid><doi>10.1007/s10856-020-06368-8</doi><tpages>11</tpages></addata></record> |
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| issn | 0957-4530 1573-4838 |
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| subjects | Alkaline phosphatase Animals Biocompatible Materials - chemistry Bioglass Biological activity Biological effects Biomaterials Biomedical Engineering and Bioengineering Biomedical materials Body fluids Bone healing Bone marrow Bone Marrow Cells - drug effects Calcium - chemistry Calcium ions Cell Differentiation Cell Proliferation Cells, Cultured Ceramics Chemistry and Materials Science Composites Differentiation (biology) Engineering Engineering and Nano-engineering Approaches for Medical Devices Engineering, Biomedical Feasibility Gene expression Glass Glass - chemistry Hydroxyapatite In vitro methods and tests Ions Materials Science Materials Science, Biomaterials Mesenchymal stem cells Mesenchymal Stem Cells - drug effects Morphology Nanoparticles - chemistry Nanotechnology Natural Materials Nodules Osteogenesis - drug effects Particle Size Physicochemical properties Polymer Sciences Rats Rats, Sprague-Dawley Regenerative Medicine/Tissue Engineering Repair Science & Technology Smooth boundaries Stem cell transplantation Stem cells Surface Properties Surfaces and Interfaces Surgical implants Technology Thin Films Tissue Scaffolds - chemistry |
| title | Effect of nanoscale bioactive glass with radial spherical particles on osteogenic differentiation of rat bone marrow mesenchymal stem cells |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-01T20%3A34%3A04IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effect%20of%20nanoscale%20bioactive%20glass%20with%20radial%20spherical%20particles%20on%20osteogenic%20differentiation%20of%20rat%20bone%20marrow%20mesenchymal%20stem%20cells&rft.jtitle=Journal%20of%20materials%20science.%20Materials%20in%20medicine&rft.au=Wang,%20Lili&rft.date=2020-03-05&rft.volume=31&rft.issue=3&rft.spage=29&rft.pages=29-&rft.artnum=29&rft.issn=0957-4530&rft.eissn=1573-4838&rft_id=info:doi/10.1007/s10856-020-06368-8&rft_dat=%3Cproquest_pubme%3E2371560392%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2371560392&rft_id=info:pmid/32140885&rfr_iscdi=true |