Discovery of T-1101 tosylate as a first-in-class clinical candidate for Hec1/Nek2 inhibition in cancer therapy

Highly expressed in cancer 1 (Hec1) plays an essential role in mitosis and is correlated with cancer formation, progression, and survival. Phosphorylation of Hec1 by Nek2 kinase is essential for its mitotic function, thus any disruption of Hec1/Nek2 protein–protein interaction has potential for canc...

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Veröffentlicht in:	European journal of medicinal chemistry 2020-04, Vol.191, p.112118-112118, Article 112118
Hauptverfasser:	Chuang, Shih-Hsien, Lee, Ying-Shuan E., Huang, Lynn Y.L., Chen, Chi-Kuan, Lai, Chun-Liang, Lin, Yu-Hsiang, Yang, Ju-Ying, Yang, Sheng-Chuan, Chang, Lien-Hsiang, Chen, Ching-Hui, Liu, Chia-Wei, Lin, Her-Sheng, Lee, Yi-Ru, Huang, Kuan Pin, Fu, Kuo Chu, Jen, Hsueh-Min, Lai, Jun-Yu, Jian, Pei-Shiou, Wang, Yu-Chuan, Hsueh, Wen-Yun, Tsai, Pei-Yi, Hong, Wan-Hua, Chang, Chia-Chi, Wu, Diana ZC, Wu, Jinn, Chen, Meng-Hsin, Yu, Kuo-Ming, Chern, Ching Yuh, Chang, Jia-Ming, Lau, Johnson Y.N., Huang, Jiann-Jyh
Format:	Artikel
Sprache:	eng
Schlagworte:	2-Aminothiazole Anticancer Hec1 Nek2 Thiazole
Online-Zugang:	Volltext
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