Osteoporosis screening using computed tomography for men with prostate cancer: results of a prospective study
Summary We performed a prospective study using both FRAX and computed tomography to screen for osteoporosis in men undergoing radiation for prostate cancer. We found that implementing routine computed tomography (CT)-based screening was feasible in the setting of a prospective study, but the yield o...
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| Veröffentlicht in: | Archives of osteoporosis 2020-02, Vol.15 (1), p.32-32, Article 32 |
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| creator | McDonald, Andrew M. Yang, Eddy S. Saag, Kenneth G. Levitan, Emily B. Wright, Nicole C. Fiveash, John B. Rais-Bahrami, Soroush Bhatia, Smita |
| description | Summary
We performed a prospective study using both FRAX and computed tomography to screen for osteoporosis in men undergoing radiation for prostate cancer. We found that implementing routine computed tomography (CT)-based screening was feasible in the setting of a prospective study, but the yield of osteoporosis identification was low in this population.
Purpose
Men with prostate cancer (PCa) are at increased risk of hip fracture for multiple reasons. Estimation of hip fracture risk with the FRAX tool is currently recommended, but FRAX alone may not identify a portion of men with osteoporosis. We hypothesized that adding bone mineral density (BMD) screening using CT to FRAX is feasible and would identify more men with osteoporosis.
Methods
Men with PCa scheduled to undergo CT simulation for radiation treatment were enrolled in a single-arm prospective study. The mean attenuation of the mid-L5 vertebral body trabecular bone (L5
CT
) was calculated on a single slice using the radiation simulation CT scan. The 10-year risk of hip fracture was calculated using the FRAX tool. Dual energy X-ray absorptiometry (DXA) was performed for men whose L5
CT
measurement was less than 130 Hounsfield units (HU).
Results
A total of 98 eligible men were enrolled and underwent FRAX and CT screening. The median 10-year risk of hip fracture was 1.1% and exceeded 3% in 16 cases; the median L5
CT
was 162.28 HU (range 55.6–526.1 HU). DXA scan was completed in 15 men who had L5
CT |
| doi_str_mv | 10.1007/s11657-020-0711-1 |
| format | Article |
| fullrecord | <record><control><sourceid>pubmed_cross</sourceid><recordid>TN_cdi_pubmed_primary_32112196</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>32112196</sourcerecordid><originalsourceid>FETCH-LOGICAL-c442t-4bcd3bf5bb77b6300196efff16a5a1d70d46eec629ebab3e05bdb97f8d5408a53</originalsourceid><addsrcrecordid>eNp9kMtOxCAUhonR6Hh5ADeGF6hyaEtnXJgY4y2ZxI2uCdDDTM20NEDHzNvLWJ3oxs3hJP8F-Ag5B3YJjFVXAUCUVcY4y1gFkMEemcBU8Cwvodjf7ZwfkeMQ3hkTDEpxSI5yDsBhJiakfQkRXe-8C02gwXjErukWdAjbaVzbDxFrGl3rFl71yw21ztMWO_rRxCXtUy6qiNSozqC_ph7DsIqBOkvVl9qjic0aaYhDvTklB1atAp59nyfk7eH-9e4pm788Pt_dzjNTFDxmhTZ1rm2pdVVpkTOWnorWWhCqVFBXrC4EohF8hlrpHFmpaz2r7LQuCzZVZX5CbsbeftAt1ga76NVK9r5pld9Ipxr5V-mapVy4tawKxgsQqQDGApO-EDzaXRaY3LKXI3uZ2Mstewkpc_H70l3iB3Yy8NEQktQt0Mt3N_gugfin9RMja5Rn</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Osteoporosis screening using computed tomography for men with prostate cancer: results of a prospective study</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>McDonald, Andrew M. ; Yang, Eddy S. ; Saag, Kenneth G. ; Levitan, Emily B. ; Wright, Nicole C. ; Fiveash, John B. ; Rais-Bahrami, Soroush ; Bhatia, Smita</creator><creatorcontrib>McDonald, Andrew M. ; Yang, Eddy S. ; Saag, Kenneth G. ; Levitan, Emily B. ; Wright, Nicole C. ; Fiveash, John B. ; Rais-Bahrami, Soroush ; Bhatia, Smita</creatorcontrib><description>Summary
We performed a prospective study using both FRAX and computed tomography to screen for osteoporosis in men undergoing radiation for prostate cancer. We found that implementing routine computed tomography (CT)-based screening was feasible in the setting of a prospective study, but the yield of osteoporosis identification was low in this population.
Purpose
Men with prostate cancer (PCa) are at increased risk of hip fracture for multiple reasons. Estimation of hip fracture risk with the FRAX tool is currently recommended, but FRAX alone may not identify a portion of men with osteoporosis. We hypothesized that adding bone mineral density (BMD) screening using CT to FRAX is feasible and would identify more men with osteoporosis.
Methods
Men with PCa scheduled to undergo CT simulation for radiation treatment were enrolled in a single-arm prospective study. The mean attenuation of the mid-L5 vertebral body trabecular bone (L5
CT
) was calculated on a single slice using the radiation simulation CT scan. The 10-year risk of hip fracture was calculated using the FRAX tool. Dual energy X-ray absorptiometry (DXA) was performed for men whose L5
CT
measurement was less than 130 Hounsfield units (HU).
Results
A total of 98 eligible men were enrolled and underwent FRAX and CT screening. The median 10-year risk of hip fracture was 1.1% and exceeded 3% in 16 cases; the median L5
CT
was 162.28 HU (range 55.6–526.1 HU). DXA scan was completed in 15 men who had L5
CT
< 130 HU but 10-year calculated hip fracture risk < 3%, 1 of whom was found to have osteoporosis (T-score ≤ −2.5).
Conclusions
Implementing CT-based BMD screening was feasible in the setting of a prospective study for men receiving radiation for PCa, but fewer cases than anticipated of osteoporosis were identified.</description><identifier>ISSN: 1862-3522</identifier><identifier>EISSN: 1862-3514</identifier><identifier>DOI: 10.1007/s11657-020-0711-1</identifier><identifier>PMID: 32112196</identifier><language>eng</language><publisher>London: Springer London</publisher><subject>Absorptiometry, Photon - methods ; Adult ; Aged ; Aged, 80 and over ; Algorithms ; Bone Density ; Cancellous Bone - diagnostic imaging ; Endocrinology ; Feasibility Studies ; Hip Fractures - diagnostic imaging ; Hip Fractures - etiology ; Humans ; Male ; Mass Screening - methods ; Medicine ; Medicine & Public Health ; Middle Aged ; Orthopedics ; Osteoporosis - diagnostic imaging ; Osteoporosis - etiology ; Prospective Studies ; Prostatic Neoplasms - physiopathology ; Prostatic Neoplasms - radiotherapy ; Radiation Injuries - diagnostic imaging ; Radiation Injuries - etiology ; Review ; Risk Assessment ; Tomography, X-Ray Computed - methods</subject><ispartof>Archives of osteoporosis, 2020-02, Vol.15 (1), p.32-32, Article 32</ispartof><rights>International Osteoporosis Foundation and National Osteoporosis Foundation 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c442t-4bcd3bf5bb77b6300196efff16a5a1d70d46eec629ebab3e05bdb97f8d5408a53</citedby><cites>FETCH-LOGICAL-c442t-4bcd3bf5bb77b6300196efff16a5a1d70d46eec629ebab3e05bdb97f8d5408a53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11657-020-0711-1$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11657-020-0711-1$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,777,781,882,27905,27906,41469,42538,51300</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32112196$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>McDonald, Andrew M.</creatorcontrib><creatorcontrib>Yang, Eddy S.</creatorcontrib><creatorcontrib>Saag, Kenneth G.</creatorcontrib><creatorcontrib>Levitan, Emily B.</creatorcontrib><creatorcontrib>Wright, Nicole C.</creatorcontrib><creatorcontrib>Fiveash, John B.</creatorcontrib><creatorcontrib>Rais-Bahrami, Soroush</creatorcontrib><creatorcontrib>Bhatia, Smita</creatorcontrib><title>Osteoporosis screening using computed tomography for men with prostate cancer: results of a prospective study</title><title>Archives of osteoporosis</title><addtitle>Arch Osteoporos</addtitle><addtitle>Arch Osteoporos</addtitle><description>Summary
We performed a prospective study using both FRAX and computed tomography to screen for osteoporosis in men undergoing radiation for prostate cancer. We found that implementing routine computed tomography (CT)-based screening was feasible in the setting of a prospective study, but the yield of osteoporosis identification was low in this population.
Purpose
Men with prostate cancer (PCa) are at increased risk of hip fracture for multiple reasons. Estimation of hip fracture risk with the FRAX tool is currently recommended, but FRAX alone may not identify a portion of men with osteoporosis. We hypothesized that adding bone mineral density (BMD) screening using CT to FRAX is feasible and would identify more men with osteoporosis.
Methods
Men with PCa scheduled to undergo CT simulation for radiation treatment were enrolled in a single-arm prospective study. The mean attenuation of the mid-L5 vertebral body trabecular bone (L5
CT
) was calculated on a single slice using the radiation simulation CT scan. The 10-year risk of hip fracture was calculated using the FRAX tool. Dual energy X-ray absorptiometry (DXA) was performed for men whose L5
CT
measurement was less than 130 Hounsfield units (HU).
Results
A total of 98 eligible men were enrolled and underwent FRAX and CT screening. The median 10-year risk of hip fracture was 1.1% and exceeded 3% in 16 cases; the median L5
CT
was 162.28 HU (range 55.6–526.1 HU). DXA scan was completed in 15 men who had L5
CT
< 130 HU but 10-year calculated hip fracture risk < 3%, 1 of whom was found to have osteoporosis (T-score ≤ −2.5).
Conclusions
Implementing CT-based BMD screening was feasible in the setting of a prospective study for men receiving radiation for PCa, but fewer cases than anticipated of osteoporosis were identified.</description><subject>Absorptiometry, Photon - methods</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Algorithms</subject><subject>Bone Density</subject><subject>Cancellous Bone - diagnostic imaging</subject><subject>Endocrinology</subject><subject>Feasibility Studies</subject><subject>Hip Fractures - diagnostic imaging</subject><subject>Hip Fractures - etiology</subject><subject>Humans</subject><subject>Male</subject><subject>Mass Screening - methods</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Orthopedics</subject><subject>Osteoporosis - diagnostic imaging</subject><subject>Osteoporosis - etiology</subject><subject>Prospective Studies</subject><subject>Prostatic Neoplasms - physiopathology</subject><subject>Prostatic Neoplasms - radiotherapy</subject><subject>Radiation Injuries - diagnostic imaging</subject><subject>Radiation Injuries - etiology</subject><subject>Review</subject><subject>Risk Assessment</subject><subject>Tomography, X-Ray Computed - methods</subject><issn>1862-3522</issn><issn>1862-3514</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMtOxCAUhonR6Hh5ADeGF6hyaEtnXJgY4y2ZxI2uCdDDTM20NEDHzNvLWJ3oxs3hJP8F-Ag5B3YJjFVXAUCUVcY4y1gFkMEemcBU8Cwvodjf7ZwfkeMQ3hkTDEpxSI5yDsBhJiakfQkRXe-8C02gwXjErukWdAjbaVzbDxFrGl3rFl71yw21ztMWO_rRxCXtUy6qiNSozqC_ph7DsIqBOkvVl9qjic0aaYhDvTklB1atAp59nyfk7eH-9e4pm788Pt_dzjNTFDxmhTZ1rm2pdVVpkTOWnorWWhCqVFBXrC4EohF8hlrpHFmpaz2r7LQuCzZVZX5CbsbeftAt1ga76NVK9r5pld9Ipxr5V-mapVy4tawKxgsQqQDGApO-EDzaXRaY3LKXI3uZ2Mstewkpc_H70l3iB3Yy8NEQktQt0Mt3N_gugfin9RMja5Rn</recordid><startdate>20200229</startdate><enddate>20200229</enddate><creator>McDonald, Andrew M.</creator><creator>Yang, Eddy S.</creator><creator>Saag, Kenneth G.</creator><creator>Levitan, Emily B.</creator><creator>Wright, Nicole C.</creator><creator>Fiveash, John B.</creator><creator>Rais-Bahrami, Soroush</creator><creator>Bhatia, Smita</creator><general>Springer London</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope></search><sort><creationdate>20200229</creationdate><title>Osteoporosis screening using computed tomography for men with prostate cancer: results of a prospective study</title><author>McDonald, Andrew M. ; Yang, Eddy S. ; Saag, Kenneth G. ; Levitan, Emily B. ; Wright, Nicole C. ; Fiveash, John B. ; Rais-Bahrami, Soroush ; Bhatia, Smita</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c442t-4bcd3bf5bb77b6300196efff16a5a1d70d46eec629ebab3e05bdb97f8d5408a53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Absorptiometry, Photon - methods</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Algorithms</topic><topic>Bone Density</topic><topic>Cancellous Bone - diagnostic imaging</topic><topic>Endocrinology</topic><topic>Feasibility Studies</topic><topic>Hip Fractures - diagnostic imaging</topic><topic>Hip Fractures - etiology</topic><topic>Humans</topic><topic>Male</topic><topic>Mass Screening - methods</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Orthopedics</topic><topic>Osteoporosis - diagnostic imaging</topic><topic>Osteoporosis - etiology</topic><topic>Prospective Studies</topic><topic>Prostatic Neoplasms - physiopathology</topic><topic>Prostatic Neoplasms - radiotherapy</topic><topic>Radiation Injuries - diagnostic imaging</topic><topic>Radiation Injuries - etiology</topic><topic>Review</topic><topic>Risk Assessment</topic><topic>Tomography, X-Ray Computed - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>McDonald, Andrew M.</creatorcontrib><creatorcontrib>Yang, Eddy S.</creatorcontrib><creatorcontrib>Saag, Kenneth G.</creatorcontrib><creatorcontrib>Levitan, Emily B.</creatorcontrib><creatorcontrib>Wright, Nicole C.</creatorcontrib><creatorcontrib>Fiveash, John B.</creatorcontrib><creatorcontrib>Rais-Bahrami, Soroush</creatorcontrib><creatorcontrib>Bhatia, Smita</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Archives of osteoporosis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>McDonald, Andrew M.</au><au>Yang, Eddy S.</au><au>Saag, Kenneth G.</au><au>Levitan, Emily B.</au><au>Wright, Nicole C.</au><au>Fiveash, John B.</au><au>Rais-Bahrami, Soroush</au><au>Bhatia, Smita</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Osteoporosis screening using computed tomography for men with prostate cancer: results of a prospective study</atitle><jtitle>Archives of osteoporosis</jtitle><stitle>Arch Osteoporos</stitle><addtitle>Arch Osteoporos</addtitle><date>2020-02-29</date><risdate>2020</risdate><volume>15</volume><issue>1</issue><spage>32</spage><epage>32</epage><pages>32-32</pages><artnum>32</artnum><issn>1862-3522</issn><eissn>1862-3514</eissn><abstract>Summary
We performed a prospective study using both FRAX and computed tomography to screen for osteoporosis in men undergoing radiation for prostate cancer. We found that implementing routine computed tomography (CT)-based screening was feasible in the setting of a prospective study, but the yield of osteoporosis identification was low in this population.
Purpose
Men with prostate cancer (PCa) are at increased risk of hip fracture for multiple reasons. Estimation of hip fracture risk with the FRAX tool is currently recommended, but FRAX alone may not identify a portion of men with osteoporosis. We hypothesized that adding bone mineral density (BMD) screening using CT to FRAX is feasible and would identify more men with osteoporosis.
Methods
Men with PCa scheduled to undergo CT simulation for radiation treatment were enrolled in a single-arm prospective study. The mean attenuation of the mid-L5 vertebral body trabecular bone (L5
CT
) was calculated on a single slice using the radiation simulation CT scan. The 10-year risk of hip fracture was calculated using the FRAX tool. Dual energy X-ray absorptiometry (DXA) was performed for men whose L5
CT
measurement was less than 130 Hounsfield units (HU).
Results
A total of 98 eligible men were enrolled and underwent FRAX and CT screening. The median 10-year risk of hip fracture was 1.1% and exceeded 3% in 16 cases; the median L5
CT
was 162.28 HU (range 55.6–526.1 HU). DXA scan was completed in 15 men who had L5
CT
< 130 HU but 10-year calculated hip fracture risk < 3%, 1 of whom was found to have osteoporosis (T-score ≤ −2.5).
Conclusions
Implementing CT-based BMD screening was feasible in the setting of a prospective study for men receiving radiation for PCa, but fewer cases than anticipated of osteoporosis were identified.</abstract><cop>London</cop><pub>Springer London</pub><pmid>32112196</pmid><doi>10.1007/s11657-020-0711-1</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1862-3522 |
| ispartof | Archives of osteoporosis, 2020-02, Vol.15 (1), p.32-32, Article 32 |
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| language | eng |
| recordid | cdi_pubmed_primary_32112196 |
| source | MEDLINE; SpringerLink Journals |
| subjects | Absorptiometry, Photon - methods Adult Aged Aged, 80 and over Algorithms Bone Density Cancellous Bone - diagnostic imaging Endocrinology Feasibility Studies Hip Fractures - diagnostic imaging Hip Fractures - etiology Humans Male Mass Screening - methods Medicine Medicine & Public Health Middle Aged Orthopedics Osteoporosis - diagnostic imaging Osteoporosis - etiology Prospective Studies Prostatic Neoplasms - physiopathology Prostatic Neoplasms - radiotherapy Radiation Injuries - diagnostic imaging Radiation Injuries - etiology Review Risk Assessment Tomography, X-Ray Computed - methods |
| title | Osteoporosis screening using computed tomography for men with prostate cancer: results of a prospective study |
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