Effects of combined 5-HT 2A and cannabinoid receptor modulation on a schizophrenia-related prepulse inhibition deficit in mice

Prepulse inhibition of the startle reflex (PPI) is disrupted in several psychiatric disorders including schizophrenia. Understanding PPI pharmacology may help elucidate the pathophysiology of these disorders and lead to better treatments. Given the advantages of multi-target approaches for complex m...

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Veröffentlicht in:	Psychopharmacology (Berlin, Germany) Germany), 2020-06, Vol.237 (6), p.1643
Hauptverfasser:	Marques, Adriana M, Macena, Michele V, Cardoso, Aline R, Hammes, Camila S O, Pinheiro, Fernanda M L, Castro, Newton G, Neves, Gilda A
Format:	Artikel
Sprache:	eng
Schlagworte:	8-Hydroxy-2-(di-n-propylamino)tetralin - administration & dosage Animals Benzoxazines - administration & dosage Cannabinoid Receptor Antagonists - administration & dosage Cannabinoid Receptor Modulators - administration & dosage Cannabinoids - administration & dosage Dose-Response Relationship, Drug Drug Therapy, Combination Fluorobenzenes - administration & dosage Male Mice Morpholines - administration & dosage Naphthalenes - administration & dosage Piperidines - administration & dosage Prepulse Inhibition - drug effects Prepulse Inhibition - physiology Receptor, Serotonin, 5-HT2A - physiology Receptors, Cannabinoid - physiology Reflex, Startle - drug effects Reflex, Startle - physiology Schizophrenia - drug therapy Serotonin 5-HT2 Receptor Agonists - administration & dosage Serotonin 5-HT2 Receptor Antagonists - administration & dosage Treatment Outcome
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