Novel Hydrophilic Camptothecin Derivatives Conjugated to Branched Glycerol Trimer Suppress Tumor Growth without Causing Diarrhea in Murine Xenograft Models of Human Lung Cancer

Camptothecin possesses broad antitumor spectra on various cancers. In spite of its marked tumor-suppressing potency, camptothecin is too hydrophobic to be solved in water and therefore not currently in clinical use. CPT-11 (irinotecan) is one of the hydrophilic analogues of camptothecin and widely p...

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Veröffentlicht in:	Molecular pharmaceutics 2020-04, Vol.17 (4), p.1049-1058
Hauptverfasser:	Tsuchihashi, Yuki, Abe, Shinji, Miyamoto, Licht, Tsunematsu, Honoka, Izumi, Toshihiro, Hatano, Aya, Okuno, Hiroko, Yamane, Megumi, Yasuoka, Takashi, Ikeda, Yasumasa, Tsuchiya, Koichiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Life Sciences & Biomedicine Medicine, Research & Experimental Pharmacology & Pharmacy Research & Experimental Medicine Science & Technology
Online-Zugang:	Volltext
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