Effects of PM 10 on mortality in pure COPD and asthma-COPD overlap: difference in exposure duration, gender, and smoking status
We investigated the effects of particulate matter (PM) on mortality in patients diagnosed with asthma-COPD overlap (ACO) or 'pure COPD'. Subjects from the National Health Insurance Service-National Sample Cohort of Korea, who were aged 40 years or above and had newly diagnosed COPD since 2...
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description | We investigated the effects of particulate matter (PM) on mortality in patients diagnosed with asthma-COPD overlap (ACO) or 'pure COPD'. Subjects from the National Health Insurance Service-National Sample Cohort of Korea, who were aged 40 years or above and had newly diagnosed COPD since 2009 were selected. Finally, 6,313 patients were enrolled and divided into 'pure COPD' and ACO groups. Average PM
exposure data were obtained using Kriging interpolation from 2001 to 2013. Hazard ratios(HR) were estimated using a time-varying Cox regression model. Exposure to PM
for 1, 3, and 6 months was associated with an increase in non-accidental mortality in the entire COPD group, especially the ACO group. When a stratified analysis of 3-month exposure was performed by sex, the highest HR was found in women with ACO (HR = 1.153; 95% confidence intervals [CI]: 1.121, 1.185). A stratified analysis according to smoking status showed that ACO patients had the highest HR among never smokers (HR = 1.151; 95% CI; 1.124, 1.178). Average exposure to PM
was associated with non-accidental mortality in patients with COPD, especially those diagnosed with ACO. In addition, the adverse effects of PM
exposure are more severe in women and never-smokers. |
format | Article |
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exposure data were obtained using Kriging interpolation from 2001 to 2013. Hazard ratios(HR) were estimated using a time-varying Cox regression model. Exposure to PM
for 1, 3, and 6 months was associated with an increase in non-accidental mortality in the entire COPD group, especially the ACO group. When a stratified analysis of 3-month exposure was performed by sex, the highest HR was found in women with ACO (HR = 1.153; 95% confidence intervals [CI]: 1.121, 1.185). A stratified analysis according to smoking status showed that ACO patients had the highest HR among never smokers (HR = 1.151; 95% CI; 1.124, 1.178). Average exposure to PM
was associated with non-accidental mortality in patients with COPD, especially those diagnosed with ACO. In addition, the adverse effects of PM
exposure are more severe in women and never-smokers.</description><identifier>EISSN: 2045-2322</identifier><identifier>PMID: 32051443</identifier><language>eng</language><publisher>England</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Asthma - mortality ; Environmental Exposure ; Female ; Humans ; Male ; Middle Aged ; Particulate Matter ; Pulmonary Disease, Chronic Obstructive - mortality ; Sex Factors ; Smoking</subject><ispartof>Scientific reports, 2020-02, Vol.10 (1), p.2402</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><orcidid>0000-0003-0843-9862</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32051443$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lee, Yu Min</creatorcontrib><creatorcontrib>Lee, Jin Hwa</creatorcontrib><creatorcontrib>Kim, Hawn-Cheol</creatorcontrib><creatorcontrib>Ha, Eunhee</creatorcontrib><title>Effects of PM 10 on mortality in pure COPD and asthma-COPD overlap: difference in exposure duration, gender, and smoking status</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><description>We investigated the effects of particulate matter (PM) on mortality in patients diagnosed with asthma-COPD overlap (ACO) or 'pure COPD'. Subjects from the National Health Insurance Service-National Sample Cohort of Korea, who were aged 40 years or above and had newly diagnosed COPD since 2009 were selected. Finally, 6,313 patients were enrolled and divided into 'pure COPD' and ACO groups. Average PM
exposure data were obtained using Kriging interpolation from 2001 to 2013. Hazard ratios(HR) were estimated using a time-varying Cox regression model. Exposure to PM
for 1, 3, and 6 months was associated with an increase in non-accidental mortality in the entire COPD group, especially the ACO group. When a stratified analysis of 3-month exposure was performed by sex, the highest HR was found in women with ACO (HR = 1.153; 95% confidence intervals [CI]: 1.121, 1.185). A stratified analysis according to smoking status showed that ACO patients had the highest HR among never smokers (HR = 1.151; 95% CI; 1.124, 1.178). Average exposure to PM
was associated with non-accidental mortality in patients with COPD, especially those diagnosed with ACO. In addition, the adverse effects of PM
exposure are more severe in women and never-smokers.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Asthma - mortality</subject><subject>Environmental Exposure</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Particulate Matter</subject><subject>Pulmonary Disease, Chronic Obstructive - mortality</subject><subject>Sex Factors</subject><subject>Smoking</subject><issn>2045-2322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFjs2KwkAQhAdBVNRXWPoBDCST5JC9Rpe9iB72Lm2mo6OZH6Yny3ry1f1Bz1uXoqC-ogZiItOiTGQu5VjMmU_pXaWsiqwaiXEu0zIrinwirqu2pSYyuBa2a8hScBaMCxE7HS-gLfg-ENSb7RLQKkCOR4PJM7tfCh36T1D6PhLINvQA6M87fkCqDxi1sws4kFUUFs8FNu6s7QE4Yux5JoYtdkzzl0_Fx9fqp_5OfL83pHY-aIPhsns_zv8t3AC0eEwq</recordid><startdate>20200212</startdate><enddate>20200212</enddate><creator>Lee, Yu Min</creator><creator>Lee, Jin Hwa</creator><creator>Kim, Hawn-Cheol</creator><creator>Ha, Eunhee</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><orcidid>https://orcid.org/0000-0003-0843-9862</orcidid></search><sort><creationdate>20200212</creationdate><title>Effects of PM 10 on mortality in pure COPD and asthma-COPD overlap: difference in exposure duration, gender, and smoking status</title><author>Lee, Yu Min ; Lee, Jin Hwa ; Kim, Hawn-Cheol ; Ha, Eunhee</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-pubmed_primary_320514433</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Asthma - mortality</topic><topic>Environmental Exposure</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Particulate Matter</topic><topic>Pulmonary Disease, Chronic Obstructive - mortality</topic><topic>Sex Factors</topic><topic>Smoking</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, Yu Min</creatorcontrib><creatorcontrib>Lee, Jin Hwa</creatorcontrib><creatorcontrib>Kim, Hawn-Cheol</creatorcontrib><creatorcontrib>Ha, Eunhee</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, Yu Min</au><au>Lee, Jin Hwa</au><au>Kim, Hawn-Cheol</au><au>Ha, Eunhee</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of PM 10 on mortality in pure COPD and asthma-COPD overlap: difference in exposure duration, gender, and smoking status</atitle><jtitle>Scientific reports</jtitle><addtitle>Sci Rep</addtitle><date>2020-02-12</date><risdate>2020</risdate><volume>10</volume><issue>1</issue><spage>2402</spage><pages>2402-</pages><eissn>2045-2322</eissn><abstract>We investigated the effects of particulate matter (PM) on mortality in patients diagnosed with asthma-COPD overlap (ACO) or 'pure COPD'. Subjects from the National Health Insurance Service-National Sample Cohort of Korea, who were aged 40 years or above and had newly diagnosed COPD since 2009 were selected. Finally, 6,313 patients were enrolled and divided into 'pure COPD' and ACO groups. Average PM
exposure data were obtained using Kriging interpolation from 2001 to 2013. Hazard ratios(HR) were estimated using a time-varying Cox regression model. Exposure to PM
for 1, 3, and 6 months was associated with an increase in non-accidental mortality in the entire COPD group, especially the ACO group. When a stratified analysis of 3-month exposure was performed by sex, the highest HR was found in women with ACO (HR = 1.153; 95% confidence intervals [CI]: 1.121, 1.185). A stratified analysis according to smoking status showed that ACO patients had the highest HR among never smokers (HR = 1.151; 95% CI; 1.124, 1.178). Average exposure to PM
was associated with non-accidental mortality in patients with COPD, especially those diagnosed with ACO. In addition, the adverse effects of PM
exposure are more severe in women and never-smokers.</abstract><cop>England</cop><pmid>32051443</pmid><orcidid>https://orcid.org/0000-0003-0843-9862</orcidid></addata></record> |
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source | MEDLINE; DOAJ Directory of Open Access Journals; Springer Nature OA Free Journals; Nature Free; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
subjects | Adult Aged Aged, 80 and over Asthma - mortality Environmental Exposure Female Humans Male Middle Aged Particulate Matter Pulmonary Disease, Chronic Obstructive - mortality Sex Factors Smoking |
title | Effects of PM 10 on mortality in pure COPD and asthma-COPD overlap: difference in exposure duration, gender, and smoking status |
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