Aspartic peptidase of Phialophora verrucosa as target of HIV peptidase inhibitors: blockage of its enzymatic activity and interference with fungal growth and macrophage interaction

Phialophora verrucosa causes several fungal human diseases, mainly chromoblastomycosis, which is extremely difficult to treat. Several studies have shown that human immunodeficiency virus peptidase inhibitors (HIV-PIs) are attractive candidates for antifungal therapies. This work focused on studying...

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Veröffentlicht in:	Journal of enzyme inhibition and medicinal chemistry 2020-01, Vol.35 (1), p.629-638
Hauptverfasser:	Granato, Marcela Q., Sousa, Ingrid S., Rosa, Thabatta L. S. A., Gonçalves, Diego S., Seabra, Sergio H., Alviano, Daniela S., Pessolani, Maria C. V., Santos, André L. S., Kneipp, Lucimar F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amprenavir Antifungal activity Antifungal Agents - chemical synthesis Antifungal Agents - chemistry Antifungal Agents - pharmacology Aspartic Acid Proteases - antagonists & inhibitors Aspartic Acid Proteases - metabolism aspartic peptidase Carbamates - chemical synthesis Carbamates - chemistry Carbamates - pharmacology cellular interaction Chromoblastomycosis Chromomycosis Conidia Dose-Response Relationship, Drug Enzymatic activity Fungi Furans HIV HIV peptidase inhibitors HIV Protease Inhibitors - chemical synthesis HIV Protease Inhibitors - chemistry HIV Protease Inhibitors - pharmacology Human immunodeficiency virus Humans Itraconazole Ketoconazole Lopinavir Lopinavir - chemical synthesis Lopinavir - chemistry Lopinavir - pharmacology Macrophages Macrophages - drug effects Macrophages - metabolism Microbial Sensitivity Tests Molecular Structure Nelfinavir Peptidase Phialophora - drug effects Phialophora - enzymology Phialophora - growth & development Phialophora verrucosa Research Paper Ritonavir Ritonavir - chemical synthesis Ritonavir - chemistry Ritonavir - pharmacology Structure-Activity Relationship Sulfonamides - chemical synthesis Sulfonamides - chemistry Sulfonamides - pharmacology
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