TBC1D9 regulates TBK1 activation through Ca 2+ signaling in selective autophagy

Invading microbial pathogens can be eliminated selectively by xenophagy. Ubiquitin-mediated autophagy receptors are phosphorylated by TANK-binding kinase 1 (TBK1) and recruited to ubiquitinated bacteria to facilitate autophagosome formation during xenophagy, but the molecular mechanism underlying TB...

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Veröffentlicht in:	Nature communications 2020-02, Vol.11 (1), p.770
Hauptverfasser:	Nozawa, Takashi, Sano, Shunsuke, Minowa-Nozawa, Atsuko, Toh, Hirotaka, Nakajima, Shintaro, Murase, Kazunori, Aikawa, Chihiro, Nakagawa, Ichiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Autophagy - physiology Binding Sites Calcium Signaling - physiology Calcium-Binding Proteins - genetics Calcium-Binding Proteins - physiology Cytosol - metabolism Gene Knockout Techniques HeLa Cells Host-Pathogen Interactions Humans Macroautophagy - physiology Membrane Proteins - genetics Membrane Proteins - physiology Mitochondria - metabolism Mitochondria - microbiology Phosphorylation Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism Streptococcal Infections - metabolism Streptococcus pyogenes - pathogenicity Ubiquitin - metabolism
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