The changing opioid crisis: development, challenges and opportunities
The current opioid epidemic is one of the most severe public health crisis in US history. Responding to it has been difficult due to its rapidly changing nature and the severity of its associated outcomes. This review examines the origin and evolution of the crisis, the pharmacological properties of...
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| Veröffentlicht in: | Molecular psychiatry 2021-01, Vol.26 (1), p.218-233 |
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| creator | Volkow, Nora D. Blanco, Carlos |
| description | The current opioid epidemic is one of the most severe public health crisis in US history. Responding to it has been difficult due to its rapidly changing nature and the severity of its associated outcomes. This review examines the origin and evolution of the crisis, the pharmacological properties of opioids, the neurobiology of opioid use and opioid use disorder (OUD), medications for opioid use disorder (MOUD), and existing and promising approaches to prevention. The results of the review indicate that the opioid epidemic is a complex, evolving phenomenon that involves neurobiological vulnerabilities and social determinants of health. Successfully addressing the epidemic will require advances in basic science, development of more acceptable and effective treatments, and implementation of public health approaches, including prevention. The advances achieved in addressing the current crisis should also serve to advance the science and treatment of other substance use disorders. |
| doi_str_mv | 10.1038/s41380-020-0661-4 |
| format | Article |
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| subjects | 631/378 692/699/476/5 Analgesics, Opioid - adverse effects Behavioral Sciences Biochemistry & Molecular Biology Biological Psychology Complications and side effects Drug addiction Epidemics Expert Review Humans Life Sciences & Biomedicine Medicine Medicine & Public Health Narcotics Nervous system Neurobiology Neurosciences Neurosciences & Neurology Opioid Epidemic Opioid-Related Disorders - drug therapy Opioid-Related Disorders - physiopathology Opioid-Related Disorders - prevention & control Opioid-Related Disorders - psychology Opioids Pharmacotherapy Physiological aspects Psychiatry Public health Science & Technology Social Factors |
| title | The changing opioid crisis: development, challenges and opportunities |
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