A20 targets PFKL and glycolysis to inhibit the progression of hepatocellular carcinoma

Abnormal expression of the E3 ubiquitin ligase A20 has been found in some malignant cancers, including hepatocellular carcinoma (HCC). Here, we discovered that A20 is an E3 ubiquitin ligase for phosphofructokinase, liver type (PFKL) in HCC A20 interacts with PFKL and promotes its degradation, theref...

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Veröffentlicht in:	Cell death & disease 2020-02, Vol.11 (2), p.89-89, Article 89
Hauptverfasser:	Feng, Yilu, Zhang, Ye, Cai, Yi, Liu, Ruijie, Lu, Miaolong, Li, Tangzhiming, Fu, Ying, Guo, Ming, Huang, Huichao, Ou, Yifu, Chen, Yongheng
Format:	Artikel
Sprache:	eng
Schlagworte:	13/1 13/109 13/21 13/44 13/51 13/89 14/19 14/35 14/63 38/77 45/29 631/45 631/67/2327 64/60 82/83 Animals Antibodies Biochemistry Biomedical and Life Sciences Carcinoma, Hepatocellular - genetics Carcinoma, Hepatocellular - metabolism Carcinoma, Hepatocellular - pathology Cell Biology Cell Culture Cell Line, Tumor Cell migration Cell Movement Cell Proliferation Disease Progression Gene Expression Regulation, Neoplastic Glucose - metabolism Glycolysis Hepatocellular carcinoma Humans Immunology Life Sciences Life Sciences & Biomedicine Liver cancer Liver Neoplasms - genetics Liver Neoplasms - metabolism Liver Neoplasms - pathology Mice Phosphofructokinase Phosphofructokinase-1, Liver Type - genetics Phosphofructokinase-1, Liver Type - metabolism Protein Binding RNA-mediated interference Science & Technology Therapeutic applications Tumor Necrosis Factor alpha-Induced Protein 3 - genetics Tumor Necrosis Factor alpha-Induced Protein 3 - metabolism Tumor suppression Tumor Suppressor Proteins - genetics Tumor Suppressor Proteins - metabolism Ubiquitin Ubiquitin-protein ligase Ubiquitination Xenograft Model Antitumor Assays
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