Hesperidin loaded Zn 2+ @ SA/PCT nanocomposites inhibit the proliferation and induces the apoptosis in colon cancer cells (HCT116) through the enhancement of pro-apoptotic protein expressions

Colon carcinoma is a recurring type of cancer that affects the intestine epithelial with a poor survival rate. It was already proven the anticancer property of hesperidin in various cancers but the bioavailability hesperidin is poor, which hinders the hesperidin usage. In this investigation we synth...

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Veröffentlicht in:	Journal of photochemistry and photobiology. B, Biology Biology, 2020-03, Vol.204, p.111767
Hauptverfasser:	Yang, Zhen, Yang, Hongwei, Dong, Xinhua, Pu, Minglong, Ji, Feihong
Format:	Artikel
Sprache:	eng
Schlagworte:	Alginates - chemistry Antineoplastic Agents, Phytogenic - chemistry Antineoplastic Agents, Phytogenic - pharmacology Caspase 3 - metabolism Cell Proliferation - drug effects Cell Survival - drug effects Colonic Neoplasms - metabolism Colonic Neoplasms - pathology Drug Compounding Drug Liberation HCT116 Cells Hesperidin - chemistry Hesperidin - pharmacology Humans Membrane Potential, Mitochondrial - drug effects Nanocomposites - chemistry Pectins - chemistry Proto-Oncogene Proteins c-bcl-2 - genetics Proto-Oncogene Proteins c-bcl-2 - metabolism Reactive Oxygen Species - metabolism Zinc - chemistry
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