Shear stress activates ATOH8 via autocrine VEGF promoting glycolysis dependent-survival of colorectal cancer cells in the circulation

Metastasis and recurrence, wherein circulating tumour cells (CTCs) play an important role, are the leading causes of death in colorectal cancer (CRC). Metastasis-initiating CTCs manage to maintain intravascular survival under anoikis, immune attack, and importantly shear stress; however, the underly...

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Veröffentlicht in:	Journal of experimental & clinical cancer research 2020-01, Vol.39 (1), p.25-16, Article 25
Hauptverfasser:	Huang, Qiong, Li, Shaowei, Hu, Xingbin, Sun, Mengting, Wu, Qijing, Dai, Huiru, Tan, Yujing, Sun, Fei, Wang, Chunlin, Rong, Xiaoxiang, Liao, Wangjun, Peng, Jianjun, Xiao, Jianjun, Huang, Li, Wang, Jiao, Liang, Bishan, Lin, Kelin, Liu, Yajing, Shi, Min
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis ATOH8 Basic Helix-Loop-Helix Transcription Factors - metabolism Cancer cells Cancer metastasis Cancer research Cell Line, Tumor Cell Survival - physiology Cohort Studies Colorectal cancer Colorectal Neoplasms - blood Colorectal Neoplasms - metabolism Colorectal Neoplasms - pathology Death Endothelial growth factors Experiments Female Flow velocity Fluorescence Fluorescent antibody technique Gene expression Genes Genotype & phenotype Glucose metabolism Glycolysis HCT116 Cells HT29 Cells Humans Hypertension Immunohistochemistry Laboratory animals Laminar shear stress Liver cancer Medical prognosis Medical research Metastasis Mice Mice, Inbred BALB C Mice, Nude Neoplasm Metastasis Neoplastic Cells, Circulating - metabolism Neoplastic Cells, Circulating - pathology Novels Physiological aspects Physiology Polymerase chain reaction Recurrence (Disease) Shear Strength Shear stress Software Stem cells Tumors Vascular endothelial growth factor Vascular Endothelial Growth Factor A - metabolism VEGF
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