Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRAS G13D

Protein-protein-interaction networks (PPINs) organize fundamental biological processes, but how oncogenic mutations impact these interactions and their functions at a network-level scale is poorly understood. Here, we analyze how a common oncogenic KRAS mutation (KRAS ) affects PPIN structure and fu...

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Veröffentlicht in:	Nature communications 2020-01, Vol.11 (1), p.499
Hauptverfasser:	Kennedy, Susan A, Jarboui, Mohamed-Ali, Srihari, Sriganesh, Raso, Cinzia, Bryan, Kenneth, Dernayka, Layal, Charitou, Theodosia, Bernal-Llinares, Manuel, Herrera-Montavez, Carlos, Krstic, Aleksandar, Matallanas, David, Kotlyar, Max, Jurisica, Igor, Curak, Jasna, Wong, Victoria, Stagljar, Igor, LeBihan, Thierry, Imrie, Lisa, Pillai, Priyanka, Lynn, Miriam A, Fasterius, Erik, Al-Khalili Szigyarto, Cristina, Breen, James, Kiel, Christina, Serrano, Luis, Rauch, Nora, Rukhlenko, Oleksii, Kholodenko, Boris N, Iglesias-Martinez, Luis F, Ryan, Colm J, Pilkington, Ruth, Cammareri, Patrizia, Sansom, Owen, Shave, Steven, Auer, Manfred, Horn, Nicola, Klose, Franziska, Ueffing, Marius, Boldt, Karsten, Lynn, David J, Kolch, Walter
Format:	Artikel
Sprache:	eng
Schlagworte:	bcl-Associated Death Protein - metabolism Cell Line, Tumor Cell Transformation, Neoplastic - pathology Colorectal Neoplasms - metabolism Colorectal Neoplasms - pathology ErbB Receptors - metabolism Humans Mutation - genetics Phosphorylation Prognosis Protein Interaction Maps Proto-Oncogene Proteins p21(ras) - genetics Survival Analysis
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