Modulation of lethal HPAIV H5N8 clade 2.3.4.4B infection in AIV pre-exposed mallards
In 2016/2017, a severe epidemic of HPAIV H5N8 clade 2.3.4.4 group B (H5N8B) affected Europe. To analyse the role of mallards in the spatiotemporal dynamics of global HPAIV H5N8B dispersal, mallards (Anas platyrhynchos), naturally exposed to various AIV and therefore seropositive, were challenged wit...
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| creator | Koethe, Susanne Ulrich, Lorenz Ulrich, Reiner Amler, Susanne Graaf, Annika Harder, Timm C. Grund, Christian Mettenleiter, Thomas C. Conraths, Franz J. Beer, Martin Globig, Anja |
| description | In 2016/2017, a severe epidemic of HPAIV H5N8 clade 2.3.4.4 group B (H5N8B) affected Europe. To analyse the role of mallards in the spatiotemporal dynamics of global HPAIV H5N8B dispersal, mallards (Anas platyrhynchos), naturally exposed to various AIV and therefore seropositive, were challenged with H5N8B. All experiments were controlled by infection and co-housing of seronegative juvenile Pekin ducklings. All ducks that survived the first infection were re-challenged 21 dpi with the homologous H5N8B strain. After the first H5N8B infection, seropositive mallards showed only mild clinical symptoms. Moderate to low viral shedding, occurring particularly from the oropharynx and lasting for 7 days maximum, led to severe clinical disease of all contact ducklings. All challenged seronegative Pekin ducks and contact ducklings died or had to be euthanized. H5-specific antibodies were detected in surviving birds within 2 weeks. Virus and viral RNA could be isolated from several water samples until 6 and 9 dpi, respectively. Conversely, upon re-infection with homologous H5N8B neither inoculated nor contact ducklings showed any clinical symptoms, nor was an antibody titer increase of seropositive mallards or any seroconversion of contact ducklings observed. Mallard ducks naturally pre-exposed to LPAIV can play a role as a clinically unsuspicious virus reservoir for H5N8B effective in virus transmission. Mallards with homologous immunity did not contribute to virus transmission. |
| doi_str_mv | 10.1080/22221751.2020.1713706 |
| format | Article |
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To analyse the role of mallards in the spatiotemporal dynamics of global HPAIV H5N8B dispersal, mallards (Anas platyrhynchos), naturally exposed to various AIV and therefore seropositive, were challenged with H5N8B. All experiments were controlled by infection and co-housing of seronegative juvenile Pekin ducklings. All ducks that survived the first infection were re-challenged 21 dpi with the homologous H5N8B strain. After the first H5N8B infection, seropositive mallards showed only mild clinical symptoms. Moderate to low viral shedding, occurring particularly from the oropharynx and lasting for 7 days maximum, led to severe clinical disease of all contact ducklings. All challenged seronegative Pekin ducks and contact ducklings died or had to be euthanized. H5-specific antibodies were detected in surviving birds within 2 weeks. Virus and viral RNA could be isolated from several water samples until 6 and 9 dpi, respectively. Conversely, upon re-infection with homologous H5N8B neither inoculated nor contact ducklings showed any clinical symptoms, nor was an antibody titer increase of seropositive mallards or any seroconversion of contact ducklings observed. Mallard ducks naturally pre-exposed to LPAIV can play a role as a clinically unsuspicious virus reservoir for H5N8B effective in virus transmission. Mallards with homologous immunity did not contribute to virus transmission.</description><identifier>ISSN: 2222-1751</identifier><identifier>EISSN: 2222-1751</identifier><identifier>DOI: 10.1080/22221751.2020.1713706</identifier><identifier>PMID: 31969057</identifier><language>eng</language><publisher>ABINGDON: Taylor & Francis</publisher><subject>AIV pre-exposure ; Animals ; Antibodies, Viral - blood ; clade 2.3.4.4 B ; Ducks - virology ; HPAIV H5N8 ; Immunology ; Infections ; Infectious Diseases ; Influenza A Virus, H5N8 Subtype - genetics ; Influenza A Virus, H5N8 Subtype - pathogenicity ; Influenza A Virus, H5N8 Subtype - physiology ; Influenza in Birds - blood ; Influenza in Birds - mortality ; Influenza in Birds - virology ; Life Sciences & Biomedicine ; Liver - virology ; mallard duck ; Microbiology ; Poultry Diseases - blood ; Poultry Diseases - mortality ; Poultry Diseases - virology ; reservoir host ; Science & Technology ; Seropositive ; Virulence ; Virus Shedding</subject><ispartof>Emerging microbes & infections, 2020-01, Vol.9 (1), p.180-193</ispartof><rights>2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group, on behalf of Shanghai Shangyixun Cultural Communication Co., Ltd 2020</rights><rights>2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group, on behalf of Shanghai Shangyixun Cultural Communication Co., Ltd. This work is licensed under the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group, on behalf of Shanghai Shangyixun Cultural Communication Co., Ltd 2020 The Author(s)</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>19</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000509326600001</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c562t-ad037d2d1f97cd0cc5464c255648b27c8863cce5dd962b24d98d167caefa39c23</citedby><cites>FETCH-LOGICAL-c562t-ad037d2d1f97cd0cc5464c255648b27c8863cce5dd962b24d98d167caefa39c23</cites><orcidid>0000-0002-0598-5254 ; 0000-0002-9403-1224 ; 0000-0001-8736-5931 ; 0000-0002-9590-8550 ; 0000-0001-6903-2906</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7006783/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7006783/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,729,782,786,866,887,2106,2118,27511,27933,27934,28257,53800,53802,59152,59153</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31969057$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Koethe, Susanne</creatorcontrib><creatorcontrib>Ulrich, Lorenz</creatorcontrib><creatorcontrib>Ulrich, Reiner</creatorcontrib><creatorcontrib>Amler, Susanne</creatorcontrib><creatorcontrib>Graaf, Annika</creatorcontrib><creatorcontrib>Harder, Timm C.</creatorcontrib><creatorcontrib>Grund, Christian</creatorcontrib><creatorcontrib>Mettenleiter, Thomas C.</creatorcontrib><creatorcontrib>Conraths, Franz J.</creatorcontrib><creatorcontrib>Beer, Martin</creatorcontrib><creatorcontrib>Globig, Anja</creatorcontrib><title>Modulation of lethal HPAIV H5N8 clade 2.3.4.4B infection in AIV pre-exposed mallards</title><title>Emerging microbes & infections</title><addtitle>EMERG MICROBES INFEC</addtitle><addtitle>Emerg Microbes Infect</addtitle><description>In 2016/2017, a severe epidemic of HPAIV H5N8 clade 2.3.4.4 group B (H5N8B) affected Europe. To analyse the role of mallards in the spatiotemporal dynamics of global HPAIV H5N8B dispersal, mallards (Anas platyrhynchos), naturally exposed to various AIV and therefore seropositive, were challenged with H5N8B. All experiments were controlled by infection and co-housing of seronegative juvenile Pekin ducklings. All ducks that survived the first infection were re-challenged 21 dpi with the homologous H5N8B strain. After the first H5N8B infection, seropositive mallards showed only mild clinical symptoms. Moderate to low viral shedding, occurring particularly from the oropharynx and lasting for 7 days maximum, led to severe clinical disease of all contact ducklings. All challenged seronegative Pekin ducks and contact ducklings died or had to be euthanized. H5-specific antibodies were detected in surviving birds within 2 weeks. Virus and viral RNA could be isolated from several water samples until 6 and 9 dpi, respectively. Conversely, upon re-infection with homologous H5N8B neither inoculated nor contact ducklings showed any clinical symptoms, nor was an antibody titer increase of seropositive mallards or any seroconversion of contact ducklings observed. Mallard ducks naturally pre-exposed to LPAIV can play a role as a clinically unsuspicious virus reservoir for H5N8B effective in virus transmission. Mallards with homologous immunity did not contribute to virus transmission.</description><subject>AIV pre-exposure</subject><subject>Animals</subject><subject>Antibodies, Viral - blood</subject><subject>clade 2.3.4.4 B</subject><subject>Ducks - virology</subject><subject>HPAIV H5N8</subject><subject>Immunology</subject><subject>Infections</subject><subject>Infectious Diseases</subject><subject>Influenza A Virus, H5N8 Subtype - genetics</subject><subject>Influenza A Virus, H5N8 Subtype - pathogenicity</subject><subject>Influenza A Virus, H5N8 Subtype - physiology</subject><subject>Influenza in Birds - blood</subject><subject>Influenza in Birds - mortality</subject><subject>Influenza in Birds - virology</subject><subject>Life Sciences & Biomedicine</subject><subject>Liver - virology</subject><subject>mallard duck</subject><subject>Microbiology</subject><subject>Poultry Diseases - blood</subject><subject>Poultry Diseases - mortality</subject><subject>Poultry Diseases - virology</subject><subject>reservoir host</subject><subject>Science & Technology</subject><subject>Seropositive</subject><subject>Virulence</subject><subject>Virus Shedding</subject><issn>2222-1751</issn><issn>2222-1751</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>0YH</sourceid><sourceid>AOWDO</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>DOA</sourceid><recordid>eNqNkktvEzEUhUcIRKvSnwAaiQ0SyuD3Y4MoUSGRymNR2Foe29M6csbBnqHtv8eTpFHLAuGNrevvHN1rn6p6CUEDgQDvUFmQU9gggEqJQ8wBe1IdT_XZdPH0wfmoOs15BcoqEIHkeXWEoWQSUH5cXX6Jdgx68LGvY1cHN1zrUC--ny1_1gv6VdQmaOtq1OCGNORj7fvOmS3t-3qCNsnN3O0mZmfrtQ5BJ5tfVM86HbI73e8n1Y9P55fzxezi2-fl_OxiZihDw0xbgLlFFnaSGwuMoYQRgyhlRLSIGyEYNsZRayVDLSJWCgsZN9p1GkuD8Em13PnaqFdqk_xapzsVtVfbQkxXSqfBm-CU5W0rHUUCW0akMFIwZq1lvBNCOKaL1_ud12Zs184a1w9Jh0emj296f62u4m_FAWBc4GLwZm-Q4q_R5UGtfTauvEjv4pgVwoQghCWZ0Nd_oas4pr48lUIUCF4-l5FC0R1lUsw5ue7QDARqioG6j4GaYqD2MSi6Vw8nOajuP70AYgfcuDZ22XjXG3fASk4okBgxNkUGzv2wTcc8jv1QpG__X1roDzu6pCamtb6JKVg16LsQU5d0b3wuXf1zmD98hd6h</recordid><startdate>20200101</startdate><enddate>20200101</enddate><creator>Koethe, Susanne</creator><creator>Ulrich, Lorenz</creator><creator>Ulrich, Reiner</creator><creator>Amler, Susanne</creator><creator>Graaf, Annika</creator><creator>Harder, Timm C.</creator><creator>Grund, Christian</creator><creator>Mettenleiter, Thomas C.</creator><creator>Conraths, Franz J.</creator><creator>Beer, Martin</creator><creator>Globig, Anja</creator><general>Taylor & Francis</general><general>Taylor & Francis Ltd</general><general>Taylor & Francis Group</general><scope>0YH</scope><scope>AOWDO</scope><scope>BLEPL</scope><scope>DTL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-0598-5254</orcidid><orcidid>https://orcid.org/0000-0002-9403-1224</orcidid><orcidid>https://orcid.org/0000-0001-8736-5931</orcidid><orcidid>https://orcid.org/0000-0002-9590-8550</orcidid><orcidid>https://orcid.org/0000-0001-6903-2906</orcidid></search><sort><creationdate>20200101</creationdate><title>Modulation of lethal HPAIV H5N8 clade 2.3.4.4B infection in AIV pre-exposed mallards</title><author>Koethe, Susanne ; Ulrich, Lorenz ; Ulrich, Reiner ; Amler, Susanne ; Graaf, Annika ; Harder, Timm C. ; Grund, Christian ; Mettenleiter, Thomas C. ; Conraths, Franz J. ; Beer, Martin ; Globig, Anja</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c562t-ad037d2d1f97cd0cc5464c255648b27c8863cce5dd962b24d98d167caefa39c23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>AIV pre-exposure</topic><topic>Animals</topic><topic>Antibodies, Viral - blood</topic><topic>clade 2.3.4.4 B</topic><topic>Ducks - virology</topic><topic>HPAIV H5N8</topic><topic>Immunology</topic><topic>Infections</topic><topic>Infectious Diseases</topic><topic>Influenza A Virus, H5N8 Subtype - genetics</topic><topic>Influenza A Virus, H5N8 Subtype - pathogenicity</topic><topic>Influenza A Virus, H5N8 Subtype - physiology</topic><topic>Influenza in Birds - blood</topic><topic>Influenza in Birds - mortality</topic><topic>Influenza in Birds - virology</topic><topic>Life Sciences & Biomedicine</topic><topic>Liver - virology</topic><topic>mallard duck</topic><topic>Microbiology</topic><topic>Poultry Diseases - blood</topic><topic>Poultry Diseases - mortality</topic><topic>Poultry Diseases - virology</topic><topic>reservoir host</topic><topic>Science & Technology</topic><topic>Seropositive</topic><topic>Virulence</topic><topic>Virus Shedding</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Koethe, Susanne</creatorcontrib><creatorcontrib>Ulrich, Lorenz</creatorcontrib><creatorcontrib>Ulrich, Reiner</creatorcontrib><creatorcontrib>Amler, Susanne</creatorcontrib><creatorcontrib>Graaf, Annika</creatorcontrib><creatorcontrib>Harder, Timm C.</creatorcontrib><creatorcontrib>Grund, Christian</creatorcontrib><creatorcontrib>Mettenleiter, Thomas C.</creatorcontrib><creatorcontrib>Conraths, Franz J.</creatorcontrib><creatorcontrib>Beer, Martin</creatorcontrib><creatorcontrib>Globig, Anja</creatorcontrib><collection>Access via Taylor & Francis (Open Access Collection)</collection><collection>Web of Science - Science Citation Index Expanded - 2020</collection><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Emerging microbes & infections</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Koethe, Susanne</au><au>Ulrich, Lorenz</au><au>Ulrich, Reiner</au><au>Amler, Susanne</au><au>Graaf, Annika</au><au>Harder, Timm C.</au><au>Grund, Christian</au><au>Mettenleiter, Thomas C.</au><au>Conraths, Franz J.</au><au>Beer, Martin</au><au>Globig, Anja</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Modulation of lethal HPAIV H5N8 clade 2.3.4.4B infection in AIV pre-exposed mallards</atitle><jtitle>Emerging microbes & infections</jtitle><stitle>EMERG MICROBES INFEC</stitle><addtitle>Emerg Microbes Infect</addtitle><date>2020-01-01</date><risdate>2020</risdate><volume>9</volume><issue>1</issue><spage>180</spage><epage>193</epage><pages>180-193</pages><issn>2222-1751</issn><eissn>2222-1751</eissn><abstract>In 2016/2017, a severe epidemic of HPAIV H5N8 clade 2.3.4.4 group B (H5N8B) affected Europe. To analyse the role of mallards in the spatiotemporal dynamics of global HPAIV H5N8B dispersal, mallards (Anas platyrhynchos), naturally exposed to various AIV and therefore seropositive, were challenged with H5N8B. All experiments were controlled by infection and co-housing of seronegative juvenile Pekin ducklings. All ducks that survived the first infection were re-challenged 21 dpi with the homologous H5N8B strain. After the first H5N8B infection, seropositive mallards showed only mild clinical symptoms. Moderate to low viral shedding, occurring particularly from the oropharynx and lasting for 7 days maximum, led to severe clinical disease of all contact ducklings. All challenged seronegative Pekin ducks and contact ducklings died or had to be euthanized. H5-specific antibodies were detected in surviving birds within 2 weeks. Virus and viral RNA could be isolated from several water samples until 6 and 9 dpi, respectively. Conversely, upon re-infection with homologous H5N8B neither inoculated nor contact ducklings showed any clinical symptoms, nor was an antibody titer increase of seropositive mallards or any seroconversion of contact ducklings observed. Mallard ducks naturally pre-exposed to LPAIV can play a role as a clinically unsuspicious virus reservoir for H5N8B effective in virus transmission. Mallards with homologous immunity did not contribute to virus transmission.</abstract><cop>ABINGDON</cop><pub>Taylor & Francis</pub><pmid>31969057</pmid><doi>10.1080/22221751.2020.1713706</doi><tpages>14</tpages><orcidid>https://orcid.org/0000-0002-0598-5254</orcidid><orcidid>https://orcid.org/0000-0002-9403-1224</orcidid><orcidid>https://orcid.org/0000-0001-8736-5931</orcidid><orcidid>https://orcid.org/0000-0002-9590-8550</orcidid><orcidid>https://orcid.org/0000-0001-6903-2906</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | AIV pre-exposure Animals Antibodies, Viral - blood clade 2.3.4.4 B Ducks - virology HPAIV H5N8 Immunology Infections Infectious Diseases Influenza A Virus, H5N8 Subtype - genetics Influenza A Virus, H5N8 Subtype - pathogenicity Influenza A Virus, H5N8 Subtype - physiology Influenza in Birds - blood Influenza in Birds - mortality Influenza in Birds - virology Life Sciences & Biomedicine Liver - virology mallard duck Microbiology Poultry Diseases - blood Poultry Diseases - mortality Poultry Diseases - virology reservoir host Science & Technology Seropositive Virulence Virus Shedding |
| title | Modulation of lethal HPAIV H5N8 clade 2.3.4.4B infection in AIV pre-exposed mallards |
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