Nup93 regulates breast tumor growth by modulating cell proliferation and actin cytoskeleton remodeling

Nucleoporin 93 (Nup93) expression inversely correlates with the survival of triple-negative breast cancer patients. However, our knowledge of Nup93 function in breast cancer besides its role as structural component of the nuclear pore complex is not understood. Combination of functional assays and g...

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Veröffentlicht in:	Life science alliance 2020-01, Vol.3 (1), p.e201900623
Hauptverfasser:	Bersini, Simone, Lytle, Nikki K, Schulte, Roberta, Huang, Ling, Wahl, Geoffrey M, Hetzer, Martin W
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Cytoskeleton - genetics Actin Cytoskeleton - metabolism Carcinogenesis - genetics Cell Line Cell Line, Tumor Cell Proliferation - genetics Chromatin - genetics Chromatin - metabolism Epithelial-Mesenchymal Transition - genetics Female Gene Expression Regulation, Neoplastic Humans LIM Domain Proteins - genetics LIM Domain Proteins - metabolism Nuclear Pore - genetics Nuclear Pore - metabolism Nuclear Pore Complex Proteins - genetics Nuclear Pore Complex Proteins - metabolism RNA Interference Triple Negative Breast Neoplasms - genetics Triple Negative Breast Neoplasms - metabolism Triple Negative Breast Neoplasms - pathology
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