Interaction of Sp1 and APP promoter elucidates a mechanism for Pb 2+ caused neurodegeneration

A ubiquitously expressed transcription factor, specificity protein 1 (Sp1), interacts with the amyloid precursor protein (APP) promoter and likely mediates APP expression. Promoter-interaction strengths variably regulate the level of APP expression. Here, we examined the interactions of finger 3 of...

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Veröffentlicht in:	Archives of biochemistry and biophysics 2020-03, Vol.681, p.108265
Hauptverfasser:	Gao, Qi, Dai, Ziwen, Zhang, Shiqing, Fang, Yuqiang, Yung, Ken Kin Lam, Lo, Pik Kwan, Lai, King Wai Chiu
Format:	Artikel
Sprache:	eng
Schlagworte:	Amyloid beta-Protein Precursor - genetics Cell Line, Tumor Humans Lead - metabolism Lead - toxicity Models, Molecular Neurons - cytology Neurons - metabolism Promoter Regions, Genetic Sp1 Transcription Factor - metabolism Transcription, Genetic
Online-Zugang:	Volltext
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