Complexes of oxoplatin with rhein and ferulic acid ligands as platinum() prodrugs with high anti-tumor activity

We herein designed two new Pt IV prodrugs of oxoplatin ( cis , cis , cis -[PtCl 2 (NH 3 ) 2 (OH) 2 ]), [Pt IV Cl 2 (NH 3 ) 2 (O 2 C-FA) 2 ] ( Pt-2 ) and [Pt IV Cl 2 (NH 3 ) 2 (O 2 C-RH) 2 ] ( Pt-3 ), by conjugating with ferulic acid (FA-COOH) and rhein (RH-COOH) which have well-known biological acti...

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