Deregulating the CYP2C19/Epoxy-Eicosatrienoic Acid-Associated FABP4/FABP5 Signaling Network as a Therapeutic Approach for Metastatic Triple-Negative Breast Cancer

Recurrence and metastasis are the main causes of triple-negative breast cancer (TNBC) mortality. On the basis of our clinical cohorts and integrative omics analyses, we hypothesized that understanding the interplay between fatty acid binding protein (FABP) and epoxy-eicosatrienoic acid (EET) driven...

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Veröffentlicht in:	Cancers 2020-01, Vol.12 (1), p.199, Article 199
Hauptverfasser:	Apaya, Maria Karmella, Hsiao, Pei-Wen, Yang, Yu-Chih, Shyur, Lie-Fen
Format:	Artikel
Sprache:	eng
Schlagworte:	Antitumor agents Breast cancer Cell interactions Cell migration Cell proliferation Cloning Doxorubicin Experiments Fatty acid-binding protein Fatty acids Gene expression Genetic transformation Glycerol Life Sciences & Biomedicine Lipids Metabolism Metabolites Metastases Metastasis Nuclear transport Oncology Peroxisome proliferator-activated receptors Protein expression Proteins Science & Technology Sterol regulatory element-binding protein Supplements Tumors Xenografts
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