Multiple roles and context-specific mechanisms underlying YAP and TAZ-mediated resistance to anti-cancer therapy

Understanding the molecular mechanisms driving resistance to anti-cancer drugs is both a crucial step to define markers of response to therapy and a clinical need in many cancer settings. YAP and TAZ transcriptional cofactors behave as oncogenes in different cancer types. Deregulation of YAP/TAZ exp...

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Veröffentlicht in:	Biochimica et biophysica acta. Reviews on cancer 2020-01, Vol.1873 (1), p.188341, Article 188341
Hauptverfasser:	Reggiani, Francesca, Gobbi, Giulia, Ciarrocchi, Alessia, Ambrosetti, Davide Carlo, Sancisi, Valentina
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - metabolism Antineoplastic Agents - therapeutic use Biochemistry & Molecular Biology Biophysics Cancer therapy Drug resistance Drug Resistance, Neoplasm - drug effects Drug Resistance, Neoplasm - genetics Gene Expression Regulation, Neoplastic - drug effects Hippo Humans Life Sciences & Biomedicine Metabolic Networks and Pathways - drug effects Metabolic Networks and Pathways - genetics Neoplasms - drug therapy Neoplasms - genetics Neoplasms - metabolism Oncology Science & Technology Signal Transduction - drug effects Signal Transduction - genetics TAZ Trans-Activators - genetics Trans-Activators - metabolism Transcription Factors - genetics Transcription Factors - metabolism Tumor Microenvironment - drug effects Tumor Microenvironment - genetics YAP
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