Analyses of the oncogenic BRAF D594G variant reveal a kinase-independent function of BRAF in activating MAPK signaling

Class 3 mutations in proto-oncogene, Ser/Thr kinase (BRAF), that result in kinase-impaired or kinase-dead BRAF have the highest mutation frequency in gene in lung adenocarcinoma. Several studies have reported that kinase-dead BRAF variants amplify mitogen-activated protein kinase (MAPK) signaling by...

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