Precise editing of myostatin signal peptide by CRISPR/Cas9 increases the muscle mass of Liang Guang Small Spotted pigs

Myostatin (MSTN), a member of the transforming growth factor-β superfamily, is a negative regulator of muscle growth and development. Disruption of the MSTN gene in various mammalian species markedly promotes muscle growth. Previous studies have mainly focused on the disruption of the MSTN peptide c...

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Veröffentlicht in:	Transgenic research 2020-02, Vol.29 (1), p.149-163
Hauptverfasser:	Li, Ruiqiang, Zeng, Wu, Ma, Miao, Wei, Zixuan, Liu, Hongbo, Liu, Xiaofeng, Wang, Min, Shi, Xuan, Zeng, Jianhua, Yang, Linfang, Mo, Delin, Liu, Xiaohong, Chen, Yaosheng, He, Zuyong
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase AKT protein Animal Genetics and Genomics Biochemical Research Methods Biochemistry & Molecular Biology Biomedical and Life Sciences Biomedical Engineering/Biotechnology Biotechnology & Applied Microbiology CRISPR Genetic Engineering Hogs Life Sciences Life Sciences & Biomedicine Molecular Medicine MSTN gene Mutation MyoD protein Myogenin Myostatin Original Paper Peptides Plant Genetics and Genomics Science & Technology Transforming growth factor-b Transgenics
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