Neonicotinoid Insecticides: Molecular Targets, Resistance, and Toxicity

Neonicotinoid Insecticides: Molecular Targets, Resistance, and Toxicity

Neonicotinoids have been used to protect crops and animals from insect pests since the 1990s, but there are concerns regarding their adverse effects on nontarget organisms, notably on bees. Enhanced resistance to neonicotinoids in pests is becoming well documented. We address the current understandi...

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Veröffentlicht in:Annual review of pharmacology and toxicology 2020-01, Vol.60 (1), p.241-255
Hauptverfasser: Matsuda, Kazuhiko, Ihara, Makoto, Sattelle, David B
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Sprache:eng
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ion channels
neonicotinoids
nicotinic acetylcholine receptors
pollinators
resistance
selective toxicity
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creator Matsuda, Kazuhiko
Ihara, Makoto
Sattelle, David B
description Neonicotinoids have been used to protect crops and animals from insect pests since the 1990s, but there are concerns regarding their adverse effects on nontarget organisms, notably on bees. Enhanced resistance to neonicotinoids in pests is becoming well documented. We address the current understanding of neonicotinoid target site interactions, selectivity, and metabolism not only in pests but also in beneficial insects such as bees. The findings are relevant to the management of both neonicotinoids and the new generation of pesticides targeting insect nicotinic acetylcholine receptors.
doi_str_mv 10.1146/annurev-pharmtox-010818-021747
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subjects ion channels
neonicotinoids
nicotinic acetylcholine receptors
pollinators
resistance
selective toxicity
title Neonicotinoid Insecticides: Molecular Targets, Resistance, and Toxicity
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