Acylglycerol kinase promotes tumour growth and metastasis via activating the PI3K/AKT/GSK3 beta signalling pathway in renal cell carcinoma

Background Clinically, the median survival in patients with metastatic renal cell carcinoma (RCC) was only 6-12 months and a 5-year survival rate of less than 20%. Therefore, an in-depth study of the molecular mechanisms involved in RCC is of great significance for improving the survival of patients...

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Veröffentlicht in:	Journal of hematology and oncology 2020-01, Vol.13 (1), p.2-2, Article 2
Hauptverfasser:	Zhu, Qian, Zhong, Ai-Lin, Hu, Hao, Zhao, Jing-Jing, Weng, De-Sheng, Tang, Yan, Pan, Qiu-Zhong, Zhou, Zi-Qi, Song, Meng-Jia, Yang, Jie-Ying, He, Jun-Yi, Liu, Yuan, Li, Min, Hu, Wan-Ming, Yang, Chao-Pin, Xiang, Tong, Chen, Ming-Yuan, Ma, Gang, Guo, Ling, Xia, Jian-Chuan
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase Acylglycerol kinase AGK AKT AKT protein Carcinoma, Renal Cell - metabolism Carcinoma, Renal Cell - pathology Cell cycle Cell Line, Tumor Cell proliferation Disease Progression Enzyme Activation Epithelial-mesenchymal transition Female G1 phase Glycogen Synthase Kinase 3 beta - metabolism Hematology Humans Immunofluorescence Immunoglobulins Immunohistochemistry Kidney cancer Kidney Neoplasms - metabolism Kidney Neoplasms - pathology Kinases LEF protein Life Sciences & Biomedicine Lipid kinase Male Medical prognosis Mesenchyme Metastases Metastasis Middle Aged Molecular modelling Neoplasm Metastasis - pathology Oncology Phase transitions Phosphatidylinositol 3-Kinases - metabolism Phosphorylation Phosphotransferases (Alcohol Group Acceptor) - metabolism PI3K Proto-Oncogene Proteins c-akt - metabolism Renal cell carcinoma S phase Science & Technology Signal Transduction Studies Tumors Western blotting Wound healing Xenografts
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