Evidence of H10N8 influenza virus infection among swine in southern China and its infectivity and transmissibility in swine
Infection with a novel H10N8 influenza virus in humans was first described in China in December 2013, which raised concerns related to public health. This novel virus was subsequently confirmed to have originated from a live poultry market. However, whether this virus can infect other mammals remain...
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| Veröffentlicht in: | Emerging microbes & infections 2020-01, Vol.9 (1), p.88-94 |
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| creator | Fu, Xinliang Huang, Yunmao Fang, Bo Liu, Yixing Cai, Mengkai Zhong, Ruting Huang, Junming Wenbao, Qi Tian, Yunbo Zhang, Guihong |
| description | Infection with a novel H10N8 influenza virus in humans was first described in China in December 2013, which raised concerns related to public health. This novel virus was subsequently confirmed to have originated from a live poultry market. However, whether this virus can infect other mammals remains unclear. In the present study, antibody specific for H10N8 influenza virus was detected in swine herds in southern China during serological monitoring for swine influenza virus. The pathogenicity and transmissibility of this H10N8 influenza virus to swine was examined. The results showed that swine are susceptible to infection with human-origin H10N8 influenza virus, which causes viral shedding, severe tissue lesions, and seroconversion, while infection with avian-origin H10N8 influenza virus causes only seroconversion and no viral shedding. Importantly, human-origin H10N8 influenza virus can inefficiently be transmitted between swine and cause seroconversion through direct contact. This study provides a new perspective regarding the ecology of H10N8 influenza virus and highlights the importance of epidemiological monitoring of the H10N8 influenza virus in different animal species, which will be helpful for preventing and controlling future infections by this virus. |
| doi_str_mv | 10.1080/22221751.2019.1708811 |
| format | Article |
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This novel virus was subsequently confirmed to have originated from a live poultry market. However, whether this virus can infect other mammals remains unclear. In the present study, antibody specific for H10N8 influenza virus was detected in swine herds in southern China during serological monitoring for swine influenza virus. The pathogenicity and transmissibility of this H10N8 influenza virus to swine was examined. The results showed that swine are susceptible to infection with human-origin H10N8 influenza virus, which causes viral shedding, severe tissue lesions, and seroconversion, while infection with avian-origin H10N8 influenza virus causes only seroconversion and no viral shedding. Importantly, human-origin H10N8 influenza virus can inefficiently be transmitted between swine and cause seroconversion through direct contact. This study provides a new perspective regarding the ecology of H10N8 influenza virus and highlights the importance of epidemiological monitoring of the H10N8 influenza virus in different animal species, which will be helpful for preventing and controlling future infections by this virus.</description><identifier>ISSN: 2222-1751</identifier><identifier>EISSN: 2222-1751</identifier><identifier>DOI: 10.1080/22221751.2019.1708811</identifier><identifier>PMID: 31900060</identifier><language>eng</language><publisher>United States: Taylor & Francis</publisher><subject>Animals ; Antibodies, Viral - immunology ; China ; H10N8 ; Humans ; Infections ; infectivity ; Influenza ; Influenza A Virus, H10N8 Subtype - pathogenicity ; Influenza A Virus, H10N8 Subtype - physiology ; influenza virus ; Lung - pathology ; Original ; Orthomyxoviridae Infections - immunology ; Orthomyxoviridae Infections - pathology ; Orthomyxoviridae Infections - transmission ; Orthomyxoviridae Infections - veterinary ; pathogenicity ; Sus scrofa ; Swine ; Swine Diseases - immunology ; Swine Diseases - pathology ; Swine Diseases - transmission ; Swine Diseases - virology ; Swine flu ; transmissibility ; Zoonoses</subject><ispartof>Emerging microbes & infections, 2020-01, Vol.9 (1), p.88-94</ispartof><rights>2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group, on behalf of Shanghai Shangyixun Cultural Communication Co., Ltd 2020</rights><rights>2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group, on behalf of Shanghai Shangyixun Cultural Communication Co., Ltd. This work is licensed under the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group, on behalf of Shanghai Shangyixun Cultural Communication Co., Ltd 2020 The Author(s)</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c562t-acf269c5716c7236f0ddec874c6ab335a314d93cfba4b2db7659e7b62b79fe673</citedby><cites>FETCH-LOGICAL-c562t-acf269c5716c7236f0ddec874c6ab335a314d93cfba4b2db7659e7b62b79fe673</cites><orcidid>0000-0002-7741-7387</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6968645/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6968645/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,27481,27903,27904,53769,53771,59119,59120</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31900060$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fu, Xinliang</creatorcontrib><creatorcontrib>Huang, Yunmao</creatorcontrib><creatorcontrib>Fang, Bo</creatorcontrib><creatorcontrib>Liu, Yixing</creatorcontrib><creatorcontrib>Cai, Mengkai</creatorcontrib><creatorcontrib>Zhong, Ruting</creatorcontrib><creatorcontrib>Huang, Junming</creatorcontrib><creatorcontrib>Wenbao, Qi</creatorcontrib><creatorcontrib>Tian, Yunbo</creatorcontrib><creatorcontrib>Zhang, Guihong</creatorcontrib><title>Evidence of H10N8 influenza virus infection among swine in southern China and its infectivity and transmissibility in swine</title><title>Emerging microbes & infections</title><addtitle>Emerg Microbes Infect</addtitle><description>Infection with a novel H10N8 influenza virus in humans was first described in China in December 2013, which raised concerns related to public health. This novel virus was subsequently confirmed to have originated from a live poultry market. However, whether this virus can infect other mammals remains unclear. In the present study, antibody specific for H10N8 influenza virus was detected in swine herds in southern China during serological monitoring for swine influenza virus. The pathogenicity and transmissibility of this H10N8 influenza virus to swine was examined. The results showed that swine are susceptible to infection with human-origin H10N8 influenza virus, which causes viral shedding, severe tissue lesions, and seroconversion, while infection with avian-origin H10N8 influenza virus causes only seroconversion and no viral shedding. Importantly, human-origin H10N8 influenza virus can inefficiently be transmitted between swine and cause seroconversion through direct contact. This study provides a new perspective regarding the ecology of H10N8 influenza virus and highlights the importance of epidemiological monitoring of the H10N8 influenza virus in different animal species, which will be helpful for preventing and controlling future infections by this virus.</description><subject>Animals</subject><subject>Antibodies, Viral - immunology</subject><subject>China</subject><subject>H10N8</subject><subject>Humans</subject><subject>Infections</subject><subject>infectivity</subject><subject>Influenza</subject><subject>Influenza A Virus, H10N8 Subtype - pathogenicity</subject><subject>Influenza A Virus, H10N8 Subtype - physiology</subject><subject>influenza virus</subject><subject>Lung - pathology</subject><subject>Original</subject><subject>Orthomyxoviridae Infections - immunology</subject><subject>Orthomyxoviridae Infections - pathology</subject><subject>Orthomyxoviridae Infections - transmission</subject><subject>Orthomyxoviridae Infections - veterinary</subject><subject>pathogenicity</subject><subject>Sus scrofa</subject><subject>Swine</subject><subject>Swine Diseases - immunology</subject><subject>Swine Diseases - pathology</subject><subject>Swine Diseases - transmission</subject><subject>Swine Diseases - virology</subject><subject>Swine flu</subject><subject>transmissibility</subject><subject>Zoonoses</subject><issn>2222-1751</issn><issn>2222-1751</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>0YH</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNp9Uk1vEzEQXSEQrUp_AsgSFy5J_bX2-oJAUaGVKrjA2fLas4mjjV3s3VQpfx5vk0ZtD8zF9ps3z_bMq6r3BM8JbvAFLUFkTeYUEzUnEjcNIa-q0wmfTYnXT_Yn1XnOa1xCYsEJf1udMKLKUeDT6u_l1jsIFlDs0BXBPxrkQ9ePEO4N2vo05ukMdvAxILOJYYnynQ9QUJTjOKwgBbRY-WCQCQ754cjf-mH3gA3JhLzxOfvW9xM4lU4a76o3nekznB_Ws-r3t8tfi6vZzc_v14uvNzNbCzrMjO2oULaWRFhJmeiwc2Abya0wLWO1YYQ7xWzXGt5S10pRK5CtoK1UHQjJzqrrva6LZq1vk9-YtNPReP0AxLTUJg3e9qC5pbwzom2wchykURy4JZKoRoJwjhWtz3ut27HdgLMQyvf6Z6LPM8Gv9DJutVCiEbwuAp8OAin-GSEPurTGQt-bAHHMmjLGBJa0nqgfX1DXcUyhtErTGjeSYiFUYdV7lk0x5wTd8TEE68kt-tEtenKLPril1H14-pNj1aM3CuHLnlAGGtPG3MXUOz2YXR9TV2ZqfS7k_97xD42Dz_k</recordid><startdate>20200101</startdate><enddate>20200101</enddate><creator>Fu, Xinliang</creator><creator>Huang, Yunmao</creator><creator>Fang, Bo</creator><creator>Liu, Yixing</creator><creator>Cai, Mengkai</creator><creator>Zhong, Ruting</creator><creator>Huang, Junming</creator><creator>Wenbao, Qi</creator><creator>Tian, Yunbo</creator><creator>Zhang, Guihong</creator><general>Taylor & Francis</general><general>Taylor & Francis Ltd</general><general>Taylor & Francis Group</general><scope>0YH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-7741-7387</orcidid></search><sort><creationdate>20200101</creationdate><title>Evidence of H10N8 influenza virus infection among swine in southern China and its infectivity and transmissibility in swine</title><author>Fu, Xinliang ; Huang, Yunmao ; Fang, Bo ; Liu, Yixing ; Cai, Mengkai ; Zhong, Ruting ; Huang, Junming ; Wenbao, Qi ; Tian, Yunbo ; Zhang, Guihong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c562t-acf269c5716c7236f0ddec874c6ab335a314d93cfba4b2db7659e7b62b79fe673</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Animals</topic><topic>Antibodies, Viral - immunology</topic><topic>China</topic><topic>H10N8</topic><topic>Humans</topic><topic>Infections</topic><topic>infectivity</topic><topic>Influenza</topic><topic>Influenza A Virus, H10N8 Subtype - pathogenicity</topic><topic>Influenza A Virus, H10N8 Subtype - physiology</topic><topic>influenza virus</topic><topic>Lung - pathology</topic><topic>Original</topic><topic>Orthomyxoviridae Infections - immunology</topic><topic>Orthomyxoviridae Infections - pathology</topic><topic>Orthomyxoviridae Infections - transmission</topic><topic>Orthomyxoviridae Infections - veterinary</topic><topic>pathogenicity</topic><topic>Sus scrofa</topic><topic>Swine</topic><topic>Swine Diseases - immunology</topic><topic>Swine Diseases - pathology</topic><topic>Swine Diseases - transmission</topic><topic>Swine Diseases - virology</topic><topic>Swine flu</topic><topic>transmissibility</topic><topic>Zoonoses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fu, Xinliang</creatorcontrib><creatorcontrib>Huang, Yunmao</creatorcontrib><creatorcontrib>Fang, Bo</creatorcontrib><creatorcontrib>Liu, Yixing</creatorcontrib><creatorcontrib>Cai, Mengkai</creatorcontrib><creatorcontrib>Zhong, Ruting</creatorcontrib><creatorcontrib>Huang, Junming</creatorcontrib><creatorcontrib>Wenbao, Qi</creatorcontrib><creatorcontrib>Tian, Yunbo</creatorcontrib><creatorcontrib>Zhang, Guihong</creatorcontrib><collection>Taylor & Francis Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Emerging microbes & infections</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fu, Xinliang</au><au>Huang, Yunmao</au><au>Fang, Bo</au><au>Liu, Yixing</au><au>Cai, Mengkai</au><au>Zhong, Ruting</au><au>Huang, Junming</au><au>Wenbao, Qi</au><au>Tian, Yunbo</au><au>Zhang, Guihong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evidence of H10N8 influenza virus infection among swine in southern China and its infectivity and transmissibility in swine</atitle><jtitle>Emerging microbes & infections</jtitle><addtitle>Emerg Microbes Infect</addtitle><date>2020-01-01</date><risdate>2020</risdate><volume>9</volume><issue>1</issue><spage>88</spage><epage>94</epage><pages>88-94</pages><issn>2222-1751</issn><eissn>2222-1751</eissn><abstract>Infection with a novel H10N8 influenza virus in humans was first described in China in December 2013, which raised concerns related to public health. This novel virus was subsequently confirmed to have originated from a live poultry market. However, whether this virus can infect other mammals remains unclear. In the present study, antibody specific for H10N8 influenza virus was detected in swine herds in southern China during serological monitoring for swine influenza virus. The pathogenicity and transmissibility of this H10N8 influenza virus to swine was examined. The results showed that swine are susceptible to infection with human-origin H10N8 influenza virus, which causes viral shedding, severe tissue lesions, and seroconversion, while infection with avian-origin H10N8 influenza virus causes only seroconversion and no viral shedding. Importantly, human-origin H10N8 influenza virus can inefficiently be transmitted between swine and cause seroconversion through direct contact. This study provides a new perspective regarding the ecology of H10N8 influenza virus and highlights the importance of epidemiological monitoring of the H10N8 influenza virus in different animal species, which will be helpful for preventing and controlling future infections by this virus.</abstract><cop>United States</cop><pub>Taylor & Francis</pub><pmid>31900060</pmid><doi>10.1080/22221751.2019.1708811</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-7741-7387</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Antibodies, Viral - immunology China H10N8 Humans Infections infectivity Influenza Influenza A Virus, H10N8 Subtype - pathogenicity Influenza A Virus, H10N8 Subtype - physiology influenza virus Lung - pathology Original Orthomyxoviridae Infections - immunology Orthomyxoviridae Infections - pathology Orthomyxoviridae Infections - transmission Orthomyxoviridae Infections - veterinary pathogenicity Sus scrofa Swine Swine Diseases - immunology Swine Diseases - pathology Swine Diseases - transmission Swine Diseases - virology Swine flu transmissibility Zoonoses |
| title | Evidence of H10N8 influenza virus infection among swine in southern China and its infectivity and transmissibility in swine |
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