Is It Just a Matter of Surgical Extension to Achieve the Cure of Hepatocarcinoma? A Meta-Analysis of Propensity-Matched and Randomized Studies for Anatomic Versus Parenchyma-Sparing Liver Resection
Background The benefit of anatomic (AR) versus parenchyma-sparing resection (PSR) in hepatocarcinoma (HCC) is still debated. The aim of the study was to compare AR vs. PSR in terms of overall survival (OS) and disease-free survival (DFS). Methods A systematic review was conducted using Medline and G...
Gespeichert in:
| Veröffentlicht in: | Journal of gastrointestinal surgery 2021, Vol.25 (1), p.94-103 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 103 |
|---|---|
| container_issue | 1 |
| container_start_page | 94 |
| container_title | Journal of gastrointestinal surgery |
| container_volume | 25 |
| creator | Famularo, Simone Ceresoli, Marco Giani, Alessandro Ciulli, Cristina Pinotti, Enrico Romano, Fabrizio Braga, Marco De Carlis, Luciano Gianotti, Luca |
| description | Background
The benefit of anatomic (AR) versus parenchyma-sparing resection (PSR) in hepatocarcinoma (HCC) is still debated. The aim of the study was to compare AR vs. PSR in terms of overall survival (OS) and disease-free survival (DFS).
Methods
A systematic review was conducted using Medline and Google Scholar. To reduce intra- and inter-study heterogeneity, only propensity-matched studies and randomized clinical trials (RCT) were evaluated and a generic inverse variance meta-analysis was run. A sub-analysis was performed in case of tumor microvascular invasion (MVI).
Results
Eleven propensity-matched and one RCT were evaluated, with a total of 3445 patients (AR = 1776 and PSR = 1669). Tumor burden and liver function were comparable among studies (
I
2
0.5). OS was similar between AR and PSR (HR 0.93; 95%CI, 0.75–1.15;
p
= 0.50,
I
2
= 41%). DFS was improved in AR at 1 year (RR 0.84; 95%CI, 0.72–0.97;
p
= 0.02;
I
2
= 36%) and 3 years (RR 0.90; 95%CI, 0.83–0.98;
p
= 0.02;
I
2
= 40%) but not at 5 years (RR 0.94; 95%CI, 0.87–1.01;
p
= 0.07;
I
2
= 41%). Furthermore, in the presence of MVI, no difference in OS and DFS was observed between AR and PSR.
Conclusion
When liver function and tumor burden are comparable, AR and PSR achieved similar overall survival. AR improved local control in the early period after surgery. Furthermore, in the presence of MVI, the extension of surgery was not associated with better OS and DFS. |
| doi_str_mv | 10.1007/s11605-019-04494-5 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmed_primary_31898106</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2484427229</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-a60a1a6551945a410f789c5fd1695f408e438df28a8abd91e2d206ba2e557b173</originalsourceid><addsrcrecordid>eNqNkcFu1DAQhiMEoqXwAhyQJS5IyGA7duKc0GpV6KKtqLqAuEWzzqTrahOnttN2eT_eC4ctReKAuNhj6_vH4__PsuecveGMlW8D5wVTlPGKMikrSdWD7JDrMqeyEMXDVLOKU6HUt4PsSQiXjPGScf04O8i5rjRnxWH2YxHIIpKPY4gEyCnEiJ64lqxGf2ENbMnxbcQ-WNeT6MjMbCxeI4kbJPPR40Se4ADRGfDG9q6Dd2RGTjECnfWw3QUbJubMu2HqEnc0PWE22BDoG3KeFtfZ7-m4imNjMZDWeZKUMV0b8hV9GAM5A4-92ew6oKsBvO0vyNJepznPMaCJaban2aMWtgGf3e1H2Zf3x5_nJ3T56cNiPltSk5cqUigYcCiU4pVUIDlrS10Z1Ta8qFQrmUaZ66YVGjSsm4qjaAQr1iBQqXLNy_woe7XvO3h3NWKIdWeDwe0WenRjqEWe5wWrkv0JffkXeulGnzxJlNRSilKIKlFiTxnvQvDY1oO3HfhdzVk9hVzvQ65TyPWvkGuVRC_uWo_rDpt7ye9UE6D3wA2uXRuMTfbhPcYYU0zlUqpUMTm3ESYP527sY5K-_n9povM9HYYpFvR_PvmP-X8CdL7Uhg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2484427229</pqid></control><display><type>article</type><title>Is It Just a Matter of Surgical Extension to Achieve the Cure of Hepatocarcinoma? A Meta-Analysis of Propensity-Matched and Randomized Studies for Anatomic Versus Parenchyma-Sparing Liver Resection</title><source>MEDLINE</source><source>SpringerNature Journals</source><source>Web of Science - Science Citation Index Expanded - 2021<img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" /></source><creator>Famularo, Simone ; Ceresoli, Marco ; Giani, Alessandro ; Ciulli, Cristina ; Pinotti, Enrico ; Romano, Fabrizio ; Braga, Marco ; De Carlis, Luciano ; Gianotti, Luca</creator><creatorcontrib>Famularo, Simone ; Ceresoli, Marco ; Giani, Alessandro ; Ciulli, Cristina ; Pinotti, Enrico ; Romano, Fabrizio ; Braga, Marco ; De Carlis, Luciano ; Gianotti, Luca</creatorcontrib><description>Background
The benefit of anatomic (AR) versus parenchyma-sparing resection (PSR) in hepatocarcinoma (HCC) is still debated. The aim of the study was to compare AR vs. PSR in terms of overall survival (OS) and disease-free survival (DFS).
Methods
A systematic review was conducted using Medline and Google Scholar. To reduce intra- and inter-study heterogeneity, only propensity-matched studies and randomized clinical trials (RCT) were evaluated and a generic inverse variance meta-analysis was run. A sub-analysis was performed in case of tumor microvascular invasion (MVI).
Results
Eleven propensity-matched and one RCT were evaluated, with a total of 3445 patients (AR = 1776 and PSR = 1669). Tumor burden and liver function were comparable among studies (
I
2
< 50%,
p
> 0.5). OS was similar between AR and PSR (HR 0.93; 95%CI, 0.75–1.15;
p
= 0.50,
I
2
= 41%). DFS was improved in AR at 1 year (RR 0.84; 95%CI, 0.72–0.97;
p
= 0.02;
I
2
= 36%) and 3 years (RR 0.90; 95%CI, 0.83–0.98;
p
= 0.02;
I
2
= 40%) but not at 5 years (RR 0.94; 95%CI, 0.87–1.01;
p
= 0.07;
I
2
= 41%). Furthermore, in the presence of MVI, no difference in OS and DFS was observed between AR and PSR.
Conclusion
When liver function and tumor burden are comparable, AR and PSR achieved similar overall survival. AR improved local control in the early period after surgery. Furthermore, in the presence of MVI, the extension of surgery was not associated with better OS and DFS.</description><identifier>ISSN: 1091-255X</identifier><identifier>EISSN: 1873-4626</identifier><identifier>DOI: 10.1007/s11605-019-04494-5</identifier><identifier>PMID: 31898106</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Carcinoma, Hepatocellular - surgery ; Disease-Free Survival ; Gastroenterology ; Gastroenterology & Hepatology ; Hepatectomy ; Humans ; Life Sciences & Biomedicine ; Liver cancer ; Liver Neoplasms - surgery ; Medical prognosis ; Medicine ; Medicine & Public Health ; Meta-analysis ; Original Article ; Randomized Controlled Trials as Topic ; Science & Technology ; Surgery ; Systematic review ; Variables</subject><ispartof>Journal of gastrointestinal surgery, 2021, Vol.25 (1), p.94-103</ispartof><rights>The Society for Surgery of the Alimentary Tract 2019</rights><rights>The Society for Surgery of the Alimentary Tract 2019.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>20</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000505344500004</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c375t-a60a1a6551945a410f789c5fd1695f408e438df28a8abd91e2d206ba2e557b173</citedby><cites>FETCH-LOGICAL-c375t-a60a1a6551945a410f789c5fd1695f408e438df28a8abd91e2d206ba2e557b173</cites><orcidid>0000-0002-9721-6304 ; 0000-0003-3063-4170 ; 0000-0003-0718-2321</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11605-019-04494-5$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11605-019-04494-5$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>315,782,786,27931,27932,39265,41495,42564,51326</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31898106$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Famularo, Simone</creatorcontrib><creatorcontrib>Ceresoli, Marco</creatorcontrib><creatorcontrib>Giani, Alessandro</creatorcontrib><creatorcontrib>Ciulli, Cristina</creatorcontrib><creatorcontrib>Pinotti, Enrico</creatorcontrib><creatorcontrib>Romano, Fabrizio</creatorcontrib><creatorcontrib>Braga, Marco</creatorcontrib><creatorcontrib>De Carlis, Luciano</creatorcontrib><creatorcontrib>Gianotti, Luca</creatorcontrib><title>Is It Just a Matter of Surgical Extension to Achieve the Cure of Hepatocarcinoma? A Meta-Analysis of Propensity-Matched and Randomized Studies for Anatomic Versus Parenchyma-Sparing Liver Resection</title><title>Journal of gastrointestinal surgery</title><addtitle>J Gastrointest Surg</addtitle><addtitle>J GASTROINTEST SURG</addtitle><addtitle>J Gastrointest Surg</addtitle><description>Background
The benefit of anatomic (AR) versus parenchyma-sparing resection (PSR) in hepatocarcinoma (HCC) is still debated. The aim of the study was to compare AR vs. PSR in terms of overall survival (OS) and disease-free survival (DFS).
Methods
A systematic review was conducted using Medline and Google Scholar. To reduce intra- and inter-study heterogeneity, only propensity-matched studies and randomized clinical trials (RCT) were evaluated and a generic inverse variance meta-analysis was run. A sub-analysis was performed in case of tumor microvascular invasion (MVI).
Results
Eleven propensity-matched and one RCT were evaluated, with a total of 3445 patients (AR = 1776 and PSR = 1669). Tumor burden and liver function were comparable among studies (
I
2
< 50%,
p
> 0.5). OS was similar between AR and PSR (HR 0.93; 95%CI, 0.75–1.15;
p
= 0.50,
I
2
= 41%). DFS was improved in AR at 1 year (RR 0.84; 95%CI, 0.72–0.97;
p
= 0.02;
I
2
= 36%) and 3 years (RR 0.90; 95%CI, 0.83–0.98;
p
= 0.02;
I
2
= 40%) but not at 5 years (RR 0.94; 95%CI, 0.87–1.01;
p
= 0.07;
I
2
= 41%). Furthermore, in the presence of MVI, no difference in OS and DFS was observed between AR and PSR.
Conclusion
When liver function and tumor burden are comparable, AR and PSR achieved similar overall survival. AR improved local control in the early period after surgery. Furthermore, in the presence of MVI, the extension of surgery was not associated with better OS and DFS.</description><subject>Carcinoma, Hepatocellular - surgery</subject><subject>Disease-Free Survival</subject><subject>Gastroenterology</subject><subject>Gastroenterology & Hepatology</subject><subject>Hepatectomy</subject><subject>Humans</subject><subject>Life Sciences & Biomedicine</subject><subject>Liver cancer</subject><subject>Liver Neoplasms - surgery</subject><subject>Medical prognosis</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Meta-analysis</subject><subject>Original Article</subject><subject>Randomized Controlled Trials as Topic</subject><subject>Science & Technology</subject><subject>Surgery</subject><subject>Systematic review</subject><subject>Variables</subject><issn>1091-255X</issn><issn>1873-4626</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>HGBXW</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqNkcFu1DAQhiMEoqXwAhyQJS5IyGA7duKc0GpV6KKtqLqAuEWzzqTrahOnttN2eT_eC4ctReKAuNhj6_vH4__PsuecveGMlW8D5wVTlPGKMikrSdWD7JDrMqeyEMXDVLOKU6HUt4PsSQiXjPGScf04O8i5rjRnxWH2YxHIIpKPY4gEyCnEiJ64lqxGf2ENbMnxbcQ-WNeT6MjMbCxeI4kbJPPR40Se4ADRGfDG9q6Dd2RGTjECnfWw3QUbJubMu2HqEnc0PWE22BDoG3KeFtfZ7-m4imNjMZDWeZKUMV0b8hV9GAM5A4-92ew6oKsBvO0vyNJepznPMaCJaban2aMWtgGf3e1H2Zf3x5_nJ3T56cNiPltSk5cqUigYcCiU4pVUIDlrS10Z1Ta8qFQrmUaZ66YVGjSsm4qjaAQr1iBQqXLNy_woe7XvO3h3NWKIdWeDwe0WenRjqEWe5wWrkv0JffkXeulGnzxJlNRSilKIKlFiTxnvQvDY1oO3HfhdzVk9hVzvQ65TyPWvkGuVRC_uWo_rDpt7ye9UE6D3wA2uXRuMTfbhPcYYU0zlUqpUMTm3ESYP527sY5K-_n9povM9HYYpFvR_PvmP-X8CdL7Uhg</recordid><startdate>2021</startdate><enddate>2021</enddate><creator>Famularo, Simone</creator><creator>Ceresoli, Marco</creator><creator>Giani, Alessandro</creator><creator>Ciulli, Cristina</creator><creator>Pinotti, Enrico</creator><creator>Romano, Fabrizio</creator><creator>Braga, Marco</creator><creator>De Carlis, Luciano</creator><creator>Gianotti, Luca</creator><general>Springer US</general><general>Springer Nature</general><general>Springer Nature B.V</general><scope>BLEPL</scope><scope>DTL</scope><scope>HGBXW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-9721-6304</orcidid><orcidid>https://orcid.org/0000-0003-3063-4170</orcidid><orcidid>https://orcid.org/0000-0003-0718-2321</orcidid></search><sort><creationdate>2021</creationdate><title>Is It Just a Matter of Surgical Extension to Achieve the Cure of Hepatocarcinoma? A Meta-Analysis of Propensity-Matched and Randomized Studies for Anatomic Versus Parenchyma-Sparing Liver Resection</title><author>Famularo, Simone ; Ceresoli, Marco ; Giani, Alessandro ; Ciulli, Cristina ; Pinotti, Enrico ; Romano, Fabrizio ; Braga, Marco ; De Carlis, Luciano ; Gianotti, Luca</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-a60a1a6551945a410f789c5fd1695f408e438df28a8abd91e2d206ba2e557b173</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Carcinoma, Hepatocellular - surgery</topic><topic>Disease-Free Survival</topic><topic>Gastroenterology</topic><topic>Gastroenterology & Hepatology</topic><topic>Hepatectomy</topic><topic>Humans</topic><topic>Life Sciences & Biomedicine</topic><topic>Liver cancer</topic><topic>Liver Neoplasms - surgery</topic><topic>Medical prognosis</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Meta-analysis</topic><topic>Original Article</topic><topic>Randomized Controlled Trials as Topic</topic><topic>Science & Technology</topic><topic>Surgery</topic><topic>Systematic review</topic><topic>Variables</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Famularo, Simone</creatorcontrib><creatorcontrib>Ceresoli, Marco</creatorcontrib><creatorcontrib>Giani, Alessandro</creatorcontrib><creatorcontrib>Ciulli, Cristina</creatorcontrib><creatorcontrib>Pinotti, Enrico</creatorcontrib><creatorcontrib>Romano, Fabrizio</creatorcontrib><creatorcontrib>Braga, Marco</creatorcontrib><creatorcontrib>De Carlis, Luciano</creatorcontrib><creatorcontrib>Gianotti, Luca</creatorcontrib><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>Web of Science - Science Citation Index Expanded - 2021</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of gastrointestinal surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Famularo, Simone</au><au>Ceresoli, Marco</au><au>Giani, Alessandro</au><au>Ciulli, Cristina</au><au>Pinotti, Enrico</au><au>Romano, Fabrizio</au><au>Braga, Marco</au><au>De Carlis, Luciano</au><au>Gianotti, Luca</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Is It Just a Matter of Surgical Extension to Achieve the Cure of Hepatocarcinoma? A Meta-Analysis of Propensity-Matched and Randomized Studies for Anatomic Versus Parenchyma-Sparing Liver Resection</atitle><jtitle>Journal of gastrointestinal surgery</jtitle><stitle>J Gastrointest Surg</stitle><stitle>J GASTROINTEST SURG</stitle><addtitle>J Gastrointest Surg</addtitle><date>2021</date><risdate>2021</risdate><volume>25</volume><issue>1</issue><spage>94</spage><epage>103</epage><pages>94-103</pages><issn>1091-255X</issn><eissn>1873-4626</eissn><abstract>Background
The benefit of anatomic (AR) versus parenchyma-sparing resection (PSR) in hepatocarcinoma (HCC) is still debated. The aim of the study was to compare AR vs. PSR in terms of overall survival (OS) and disease-free survival (DFS).
Methods
A systematic review was conducted using Medline and Google Scholar. To reduce intra- and inter-study heterogeneity, only propensity-matched studies and randomized clinical trials (RCT) were evaluated and a generic inverse variance meta-analysis was run. A sub-analysis was performed in case of tumor microvascular invasion (MVI).
Results
Eleven propensity-matched and one RCT were evaluated, with a total of 3445 patients (AR = 1776 and PSR = 1669). Tumor burden and liver function were comparable among studies (
I
2
< 50%,
p
> 0.5). OS was similar between AR and PSR (HR 0.93; 95%CI, 0.75–1.15;
p
= 0.50,
I
2
= 41%). DFS was improved in AR at 1 year (RR 0.84; 95%CI, 0.72–0.97;
p
= 0.02;
I
2
= 36%) and 3 years (RR 0.90; 95%CI, 0.83–0.98;
p
= 0.02;
I
2
= 40%) but not at 5 years (RR 0.94; 95%CI, 0.87–1.01;
p
= 0.07;
I
2
= 41%). Furthermore, in the presence of MVI, no difference in OS and DFS was observed between AR and PSR.
Conclusion
When liver function and tumor burden are comparable, AR and PSR achieved similar overall survival. AR improved local control in the early period after surgery. Furthermore, in the presence of MVI, the extension of surgery was not associated with better OS and DFS.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>31898106</pmid><doi>10.1007/s11605-019-04494-5</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-9721-6304</orcidid><orcidid>https://orcid.org/0000-0003-3063-4170</orcidid><orcidid>https://orcid.org/0000-0003-0718-2321</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1091-255X |
| ispartof | Journal of gastrointestinal surgery, 2021, Vol.25 (1), p.94-103 |
| issn | 1091-255X 1873-4626 |
| language | eng |
| recordid | cdi_pubmed_primary_31898106 |
| source | MEDLINE; SpringerNature Journals; Web of Science - Science Citation Index Expanded - 2021<img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" /> |
| subjects | Carcinoma, Hepatocellular - surgery Disease-Free Survival Gastroenterology Gastroenterology & Hepatology Hepatectomy Humans Life Sciences & Biomedicine Liver cancer Liver Neoplasms - surgery Medical prognosis Medicine Medicine & Public Health Meta-analysis Original Article Randomized Controlled Trials as Topic Science & Technology Surgery Systematic review Variables |
| title | Is It Just a Matter of Surgical Extension to Achieve the Cure of Hepatocarcinoma? A Meta-Analysis of Propensity-Matched and Randomized Studies for Anatomic Versus Parenchyma-Sparing Liver Resection |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-04T13%3A39%3A50IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Is%20It%20Just%20a%20Matter%20of%20Surgical%20Extension%20to%20Achieve%20the%20Cure%20of%20Hepatocarcinoma?%20A%20Meta-Analysis%20of%20Propensity-Matched%20and%20Randomized%20Studies%20for%20Anatomic%20Versus%20Parenchyma-Sparing%20Liver%20Resection&rft.jtitle=Journal%20of%20gastrointestinal%20surgery&rft.au=Famularo,%20Simone&rft.date=2021&rft.volume=25&rft.issue=1&rft.spage=94&rft.epage=103&rft.pages=94-103&rft.issn=1091-255X&rft.eissn=1873-4626&rft_id=info:doi/10.1007/s11605-019-04494-5&rft_dat=%3Cproquest_pubme%3E2484427229%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2484427229&rft_id=info:pmid/31898106&rfr_iscdi=true |