Size-dependent tissue-specific biological effects of core-shell structured Fe 3 O 4 @SiO 2 -NH 2 nanoparticles
Understanding the in vivo size-dependent pharmacokinetics and toxicity of nanoparticles is crucial to determine their successful development. Systematic studies on the size-dependent biological effects of nanoparticles not only help to unravel unknown toxicological mechanism but also contribute to t...
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| Veröffentlicht in: | Journal of nanobiotechnology 2019-12, Vol.17 (1), p.124 |
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| creator | Li, Jinquan Yuan, Zhongxue Liu, Huili Feng, Jianghua Chen, Zhong |
| description | Understanding the in vivo size-dependent pharmacokinetics and toxicity of nanoparticles is crucial to determine their successful development. Systematic studies on the size-dependent biological effects of nanoparticles not only help to unravel unknown toxicological mechanism but also contribute to the possible biological applications of nanomaterial.
In this study, the biodistribution and the size-dependent biological effects of Fe
O
@SiO
-NH
nanoparticles (Fe@Si-NPs) in three diameters (10, 20 and 40 nm) were investigated by ICP-AES, serum biochemistry analysis and NMR-based metabolomic analysis after intravenous administration in a rat model.
Our findings indicated that biodistribution and biological activities of Fe@Si-NPs demonstrated the obvious size-dependent and tissue-specific effects. Spleen and liver are the target tissues of Fe@Si-NPs, and 20 nm of Fe@Si-NPs showed a possible longer blood circulation time. Quantitative biochemical analysis showed that the alterations of lactate dehydrogenase (LDH) and uric acid (UA) were correlated to some extent with the sizes of Fe@Si-NPs. The untargeted metabolomic analyses of tissue metabolomes (kidney, liver, lung, and spleen) indicated that different sizes of Fe@Si-NPs were involved in the different biochemical mechanisms. LDH, formate, uric acid, and GSH related metabolites were suggested as sensitive indicators for the size-dependent toxic effects of Fe@Si-NPs. The findings from serum biochemical analysis and metabolomic analysis corroborate each other. Thus we proposed a toxicity hypothesis that size-dependent NAD depletion may occur in vivo in response to nanoparticle exposure. To our knowledge, this is the first report that links size-dependent biological effects of nanoparticles with in vivo NAD depletion in rats.
The integrated metabolomic approach is an effective tool to understand physiological responses to the size-specific properties of nanoparticles. Our results can provide a direction for the future biological applications of Fe@Si-NPs. |
| doi_str_mv | 10.1186/s12951-019-0561-4 |
| format | Article |
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In this study, the biodistribution and the size-dependent biological effects of Fe
O
@SiO
-NH
nanoparticles (Fe@Si-NPs) in three diameters (10, 20 and 40 nm) were investigated by ICP-AES, serum biochemistry analysis and NMR-based metabolomic analysis after intravenous administration in a rat model.
Our findings indicated that biodistribution and biological activities of Fe@Si-NPs demonstrated the obvious size-dependent and tissue-specific effects. Spleen and liver are the target tissues of Fe@Si-NPs, and 20 nm of Fe@Si-NPs showed a possible longer blood circulation time. Quantitative biochemical analysis showed that the alterations of lactate dehydrogenase (LDH) and uric acid (UA) were correlated to some extent with the sizes of Fe@Si-NPs. The untargeted metabolomic analyses of tissue metabolomes (kidney, liver, lung, and spleen) indicated that different sizes of Fe@Si-NPs were involved in the different biochemical mechanisms. LDH, formate, uric acid, and GSH related metabolites were suggested as sensitive indicators for the size-dependent toxic effects of Fe@Si-NPs. The findings from serum biochemical analysis and metabolomic analysis corroborate each other. Thus we proposed a toxicity hypothesis that size-dependent NAD depletion may occur in vivo in response to nanoparticle exposure. To our knowledge, this is the first report that links size-dependent biological effects of nanoparticles with in vivo NAD depletion in rats.
The integrated metabolomic approach is an effective tool to understand physiological responses to the size-specific properties of nanoparticles. Our results can provide a direction for the future biological applications of Fe@Si-NPs.</description><identifier>EISSN: 1477-3155</identifier><identifier>DOI: 10.1186/s12951-019-0561-4</identifier><identifier>PMID: 31870377</identifier><language>eng</language><publisher>England</publisher><subject>Administration, Intravenous ; Animals ; Kidney - metabolism ; L-Lactate Dehydrogenase - metabolism ; Liver - metabolism ; Lung - metabolism ; Magnetite Nanoparticles - chemistry ; Magnetite Nanoparticles - toxicity ; Male ; Metabolome ; Metabolomics ; Particle Size ; Rats ; Rats, Sprague-Dawley ; Silicon Dioxide - chemistry ; Spleen - metabolism ; Tissue Distribution ; Uric Acid - metabolism</subject><ispartof>Journal of nanobiotechnology, 2019-12, Vol.17 (1), p.124</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><orcidid>0000-0001-8899-2750</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,860,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31870377$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Jinquan</creatorcontrib><creatorcontrib>Yuan, Zhongxue</creatorcontrib><creatorcontrib>Liu, Huili</creatorcontrib><creatorcontrib>Feng, Jianghua</creatorcontrib><creatorcontrib>Chen, Zhong</creatorcontrib><title>Size-dependent tissue-specific biological effects of core-shell structured Fe 3 O 4 @SiO 2 -NH 2 nanoparticles</title><title>Journal of nanobiotechnology</title><addtitle>J Nanobiotechnology</addtitle><description>Understanding the in vivo size-dependent pharmacokinetics and toxicity of nanoparticles is crucial to determine their successful development. Systematic studies on the size-dependent biological effects of nanoparticles not only help to unravel unknown toxicological mechanism but also contribute to the possible biological applications of nanomaterial.
In this study, the biodistribution and the size-dependent biological effects of Fe
O
@SiO
-NH
nanoparticles (Fe@Si-NPs) in three diameters (10, 20 and 40 nm) were investigated by ICP-AES, serum biochemistry analysis and NMR-based metabolomic analysis after intravenous administration in a rat model.
Our findings indicated that biodistribution and biological activities of Fe@Si-NPs demonstrated the obvious size-dependent and tissue-specific effects. Spleen and liver are the target tissues of Fe@Si-NPs, and 20 nm of Fe@Si-NPs showed a possible longer blood circulation time. Quantitative biochemical analysis showed that the alterations of lactate dehydrogenase (LDH) and uric acid (UA) were correlated to some extent with the sizes of Fe@Si-NPs. The untargeted metabolomic analyses of tissue metabolomes (kidney, liver, lung, and spleen) indicated that different sizes of Fe@Si-NPs were involved in the different biochemical mechanisms. LDH, formate, uric acid, and GSH related metabolites were suggested as sensitive indicators for the size-dependent toxic effects of Fe@Si-NPs. The findings from serum biochemical analysis and metabolomic analysis corroborate each other. Thus we proposed a toxicity hypothesis that size-dependent NAD depletion may occur in vivo in response to nanoparticle exposure. To our knowledge, this is the first report that links size-dependent biological effects of nanoparticles with in vivo NAD depletion in rats.
The integrated metabolomic approach is an effective tool to understand physiological responses to the size-specific properties of nanoparticles. Our results can provide a direction for the future biological applications of Fe@Si-NPs.</description><subject>Administration, Intravenous</subject><subject>Animals</subject><subject>Kidney - metabolism</subject><subject>L-Lactate Dehydrogenase - metabolism</subject><subject>Liver - metabolism</subject><subject>Lung - metabolism</subject><subject>Magnetite Nanoparticles - chemistry</subject><subject>Magnetite Nanoparticles - toxicity</subject><subject>Male</subject><subject>Metabolome</subject><subject>Metabolomics</subject><subject>Particle Size</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Silicon Dioxide - chemistry</subject><subject>Spleen - metabolism</subject><subject>Tissue Distribution</subject><subject>Uric Acid - metabolism</subject><issn>1477-3155</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFjjtOAzEUAC0kRMLnADToXcDg38ZJh4SIUiVF6CPH-wxGjm35eQs4PSmgpplpphjG7qV4lHK5eCKpVoPkQq64GBaSmws2l8ZaruUwzNg10acQShllrthMy6UV2to5y_v4jXzEinnE3KFHogk5VfQxRA_HWFJ5j94lwBDQd4ISwJd2bj4wJaDeJt-nhiOsETTswMDzPu5AAd9uzswul-pajz4h3bLL4BLh3a9v2MP69e1lw-t0POF4qC2eXPs6_A3qf4MfhnlKqA</recordid><startdate>20191223</startdate><enddate>20191223</enddate><creator>Li, Jinquan</creator><creator>Yuan, Zhongxue</creator><creator>Liu, Huili</creator><creator>Feng, Jianghua</creator><creator>Chen, Zhong</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><orcidid>https://orcid.org/0000-0001-8899-2750</orcidid></search><sort><creationdate>20191223</creationdate><title>Size-dependent tissue-specific biological effects of core-shell structured Fe 3 O 4 @SiO 2 -NH 2 nanoparticles</title><author>Li, Jinquan ; Yuan, Zhongxue ; Liu, Huili ; Feng, Jianghua ; Chen, Zhong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-pubmed_primary_318703773</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Administration, Intravenous</topic><topic>Animals</topic><topic>Kidney - metabolism</topic><topic>L-Lactate Dehydrogenase - metabolism</topic><topic>Liver - metabolism</topic><topic>Lung - metabolism</topic><topic>Magnetite Nanoparticles - chemistry</topic><topic>Magnetite Nanoparticles - toxicity</topic><topic>Male</topic><topic>Metabolome</topic><topic>Metabolomics</topic><topic>Particle Size</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Silicon Dioxide - chemistry</topic><topic>Spleen - metabolism</topic><topic>Tissue Distribution</topic><topic>Uric Acid - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Jinquan</creatorcontrib><creatorcontrib>Yuan, Zhongxue</creatorcontrib><creatorcontrib>Liu, Huili</creatorcontrib><creatorcontrib>Feng, Jianghua</creatorcontrib><creatorcontrib>Chen, Zhong</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Journal of nanobiotechnology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Jinquan</au><au>Yuan, Zhongxue</au><au>Liu, Huili</au><au>Feng, Jianghua</au><au>Chen, Zhong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Size-dependent tissue-specific biological effects of core-shell structured Fe 3 O 4 @SiO 2 -NH 2 nanoparticles</atitle><jtitle>Journal of nanobiotechnology</jtitle><addtitle>J Nanobiotechnology</addtitle><date>2019-12-23</date><risdate>2019</risdate><volume>17</volume><issue>1</issue><spage>124</spage><pages>124-</pages><eissn>1477-3155</eissn><abstract>Understanding the in vivo size-dependent pharmacokinetics and toxicity of nanoparticles is crucial to determine their successful development. Systematic studies on the size-dependent biological effects of nanoparticles not only help to unravel unknown toxicological mechanism but also contribute to the possible biological applications of nanomaterial.
In this study, the biodistribution and the size-dependent biological effects of Fe
O
@SiO
-NH
nanoparticles (Fe@Si-NPs) in three diameters (10, 20 and 40 nm) were investigated by ICP-AES, serum biochemistry analysis and NMR-based metabolomic analysis after intravenous administration in a rat model.
Our findings indicated that biodistribution and biological activities of Fe@Si-NPs demonstrated the obvious size-dependent and tissue-specific effects. Spleen and liver are the target tissues of Fe@Si-NPs, and 20 nm of Fe@Si-NPs showed a possible longer blood circulation time. Quantitative biochemical analysis showed that the alterations of lactate dehydrogenase (LDH) and uric acid (UA) were correlated to some extent with the sizes of Fe@Si-NPs. The untargeted metabolomic analyses of tissue metabolomes (kidney, liver, lung, and spleen) indicated that different sizes of Fe@Si-NPs were involved in the different biochemical mechanisms. LDH, formate, uric acid, and GSH related metabolites were suggested as sensitive indicators for the size-dependent toxic effects of Fe@Si-NPs. The findings from serum biochemical analysis and metabolomic analysis corroborate each other. Thus we proposed a toxicity hypothesis that size-dependent NAD depletion may occur in vivo in response to nanoparticle exposure. To our knowledge, this is the first report that links size-dependent biological effects of nanoparticles with in vivo NAD depletion in rats.
The integrated metabolomic approach is an effective tool to understand physiological responses to the size-specific properties of nanoparticles. Our results can provide a direction for the future biological applications of Fe@Si-NPs.</abstract><cop>England</cop><pmid>31870377</pmid><doi>10.1186/s12951-019-0561-4</doi><orcidid>https://orcid.org/0000-0001-8899-2750</orcidid></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; PubMed Central Open Access; Springer Nature OA Free Journals; Springer Nature - Complete Springer Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Administration, Intravenous Animals Kidney - metabolism L-Lactate Dehydrogenase - metabolism Liver - metabolism Lung - metabolism Magnetite Nanoparticles - chemistry Magnetite Nanoparticles - toxicity Male Metabolome Metabolomics Particle Size Rats Rats, Sprague-Dawley Silicon Dioxide - chemistry Spleen - metabolism Tissue Distribution Uric Acid - metabolism |
| title | Size-dependent tissue-specific biological effects of core-shell structured Fe 3 O 4 @SiO 2 -NH 2 nanoparticles |
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