Bleomycin induces epithelial-to-mesenchymal transition via bFGF/PI3K/ESRP1 signaling in pulmonary fibrosis

Idiopathic pulmonary fibrosis (IPF) is a fatal and chronic disease with a high rate of infection and mortality; however, its etiology and pathogenesis remain unclear. Studies have revealed that epithelial-mesenchymal transition (EMT) is a crucial cellular event in IPF. Here, we identified that the p...

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Veröffentlicht in:	Bioscience reports 2020-01, Vol.40 (1), Article 20190756
Hauptverfasser:	Weng, Chang-Mei, Li, Qing, Chen, Kui-Jun, Xu, Cheng-Xiong, Deng, Meng-Sheng, Li, Tao, Zhang, Dong-Dong, Duan, Zhao-Xia, Chen, Zhi-Qiang, Li, Guan-Hua, Chen, Jing, Wang, Jian-Min
Format:	Artikel
Sprache:	eng
Schlagworte:	A549 Cells Animals Biochemistry & Molecular Biology Bleomycin Cell Biology Chemical Biology Disease Models, Animal Epithelial-Mesenchymal Transition - drug effects Fibroblast Growth Factor 2 - metabolism Fibroblast Growth Factor 2 - pharmacology Gene Expression & Regulation Humans Idiopathic Pulmonary Fibrosis - chemically induced Idiopathic Pulmonary Fibrosis - enzymology Idiopathic Pulmonary Fibrosis - genetics Idiopathic Pulmonary Fibrosis - pathology Life Sciences & Biomedicine Lung - drug effects Lung - enzymology Lung - pathology Male Mice Molecular Interactions Phosphatidylinositol 3-Kinase - metabolism RNA-Binding Proteins - genetics RNA-Binding Proteins - metabolism Science & Technology Signal Transduction Transforming Growth Factor beta1 - metabolism Transforming Growth Factor beta1 - pharmacology
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