Induction of gene mutations and gene conversions by vinyl chloride metabolites in yeast
Chloroethylene oxide and 2-chloroacetaldehyde, two metabolites of vinyl chloride, and 2-chloroethanol, a putative metabolic intermediate, were assayed for their genetic activity in the yeasts Schizosaccharomyces pombe and Saccharomyces cerevisiae. Chloroethylene oxide was found to be the most effect...
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| Veröffentlicht in: | Cancer research (Chicago, Ill.) Ill.), 1977-01, Vol.37 (1), p.253 |
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| container_title | Cancer research (Chicago, Ill.) |
| container_volume | 37 |
| creator | Loprieno, N Barale, R Baroncelli, S Bartsch, H Bronzetti, G Cammelini, A Corsi, C Frezza, D Nieri, R Leporini, C Rosellini, D Rossi, A M |
| description | Chloroethylene oxide and 2-chloroacetaldehyde, two metabolites of vinyl chloride, and 2-chloroethanol, a putative metabolic intermediate, were assayed for their genetic activity in the yeasts Schizosaccharomyces pombe and Saccharomyces cerevisiae. Chloroethylene oxide was found to be the most effective in inducing forward mutations in Sch. pombe and gene conversions in S. cerevisiae, increasing the mutation and conversion frequencies 340 and 50 times, respectively, over those of the controls. In either the presence or the absence of mouse liver microsomes, 2-chloroacetaldehyde showed only feeble genetic activity, and 2-chloroethanol was completely inactive in both yeast strains. In contrast to vinyl chloride, 2-chloroacetaldehyde did not induce forward mutations in Sch. pombe inthe host-mediated assay in mice. The results strongly support the hypothesis that chloroethylene oxide is one of the principal mutagenic agents formed from vinyl chloride in the presence of mouse liver enzymes. |
| format | Article |
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Chloroethylene oxide was found to be the most effective in inducing forward mutations in Sch. pombe and gene conversions in S. cerevisiae, increasing the mutation and conversion frequencies 340 and 50 times, respectively, over those of the controls. In either the presence or the absence of mouse liver microsomes, 2-chloroacetaldehyde showed only feeble genetic activity, and 2-chloroethanol was completely inactive in both yeast strains. In contrast to vinyl chloride, 2-chloroacetaldehyde did not induce forward mutations in Sch. pombe inthe host-mediated assay in mice. The results strongly support the hypothesis that chloroethylene oxide is one of the principal mutagenic agents formed from vinyl chloride in the presence of mouse liver enzymes.</description><identifier>ISSN: 0008-5472</identifier><identifier>PMID: 318606</identifier><language>eng</language><publisher>United States</publisher><subject>Acetaldehyde - analogs & derivatives ; Acetaldehyde - pharmacology ; Animals ; Ascomycota - drug effects ; Carcinogens ; Ethylene Chlorohydrin - pharmacology ; Genes - drug effects ; Male ; Mice ; Microsomes, Liver - metabolism ; Mutation - drug effects ; Saccharomyces cerevisiae - drug effects ; Schizosaccharomyces - drug effects ; Vinyl Chloride - analogs & derivatives ; Vinyl Chloride - metabolism ; Vinyl Chloride - pharmacology ; Vinyl Compounds - pharmacology</subject><ispartof>Cancer research (Chicago, Ill.), 1977-01, Vol.37 (1), p.253</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/318606$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Loprieno, N</creatorcontrib><creatorcontrib>Barale, R</creatorcontrib><creatorcontrib>Baroncelli, S</creatorcontrib><creatorcontrib>Bartsch, H</creatorcontrib><creatorcontrib>Bronzetti, G</creatorcontrib><creatorcontrib>Cammelini, A</creatorcontrib><creatorcontrib>Corsi, C</creatorcontrib><creatorcontrib>Frezza, D</creatorcontrib><creatorcontrib>Nieri, R</creatorcontrib><creatorcontrib>Leporini, C</creatorcontrib><creatorcontrib>Rosellini, D</creatorcontrib><creatorcontrib>Rossi, A M</creatorcontrib><title>Induction of gene mutations and gene conversions by vinyl chloride metabolites in yeast</title><title>Cancer research (Chicago, Ill.)</title><addtitle>Cancer Res</addtitle><description>Chloroethylene oxide and 2-chloroacetaldehyde, two metabolites of vinyl chloride, and 2-chloroethanol, a putative metabolic intermediate, were assayed for their genetic activity in the yeasts Schizosaccharomyces pombe and Saccharomyces cerevisiae. Chloroethylene oxide was found to be the most effective in inducing forward mutations in Sch. pombe and gene conversions in S. cerevisiae, increasing the mutation and conversion frequencies 340 and 50 times, respectively, over those of the controls. In either the presence or the absence of mouse liver microsomes, 2-chloroacetaldehyde showed only feeble genetic activity, and 2-chloroethanol was completely inactive in both yeast strains. In contrast to vinyl chloride, 2-chloroacetaldehyde did not induce forward mutations in Sch. pombe inthe host-mediated assay in mice. The results strongly support the hypothesis that chloroethylene oxide is one of the principal mutagenic agents formed from vinyl chloride in the presence of mouse liver enzymes.</description><subject>Acetaldehyde - analogs & derivatives</subject><subject>Acetaldehyde - pharmacology</subject><subject>Animals</subject><subject>Ascomycota - drug effects</subject><subject>Carcinogens</subject><subject>Ethylene Chlorohydrin - pharmacology</subject><subject>Genes - drug effects</subject><subject>Male</subject><subject>Mice</subject><subject>Microsomes, Liver - metabolism</subject><subject>Mutation - drug effects</subject><subject>Saccharomyces cerevisiae - drug effects</subject><subject>Schizosaccharomyces - drug effects</subject><subject>Vinyl Chloride - analogs & derivatives</subject><subject>Vinyl Chloride - metabolism</subject><subject>Vinyl Chloride - pharmacology</subject><subject>Vinyl Compounds - pharmacology</subject><issn>0008-5472</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1977</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNotj8tqwzAURLXoK037B13oBwxXlmTJyxL6CAS6aekyyNJVo2JLwZID_vumdVfDHDgDc0FWAKArKVR9Q25z_j5XyUBekyvOdAPNinxuo5tsCSnS5OkXRqTDVMwvyNREtyCb4gnH_Ae7mZ5CnHtqD30agzsLWEyX-lAw0xDpjCaXO3LpTZ_x_j_X5OP56X3zWu3eXrabx111qLkqlaoVipZrwRSzrWg0VwwYel6DlmC1l56j0t4Biq5lEphvleokGGWMc56vycOye5y6Ad3-OIbBjPN--cd_ABLRS6E</recordid><startdate>197701</startdate><enddate>197701</enddate><creator>Loprieno, N</creator><creator>Barale, R</creator><creator>Baroncelli, S</creator><creator>Bartsch, H</creator><creator>Bronzetti, G</creator><creator>Cammelini, A</creator><creator>Corsi, C</creator><creator>Frezza, D</creator><creator>Nieri, R</creator><creator>Leporini, C</creator><creator>Rosellini, D</creator><creator>Rossi, A M</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>197701</creationdate><title>Induction of gene mutations and gene conversions by vinyl chloride metabolites in yeast</title><author>Loprieno, N ; 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Chloroethylene oxide was found to be the most effective in inducing forward mutations in Sch. pombe and gene conversions in S. cerevisiae, increasing the mutation and conversion frequencies 340 and 50 times, respectively, over those of the controls. In either the presence or the absence of mouse liver microsomes, 2-chloroacetaldehyde showed only feeble genetic activity, and 2-chloroethanol was completely inactive in both yeast strains. In contrast to vinyl chloride, 2-chloroacetaldehyde did not induce forward mutations in Sch. pombe inthe host-mediated assay in mice. The results strongly support the hypothesis that chloroethylene oxide is one of the principal mutagenic agents formed from vinyl chloride in the presence of mouse liver enzymes.</abstract><cop>United States</cop><pmid>318606</pmid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0008-5472 |
| ispartof | Cancer research (Chicago, Ill.), 1977-01, Vol.37 (1), p.253 |
| issn | 0008-5472 |
| language | eng |
| recordid | cdi_pubmed_primary_318606 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; American Association for Cancer Research |
| subjects | Acetaldehyde - analogs & derivatives Acetaldehyde - pharmacology Animals Ascomycota - drug effects Carcinogens Ethylene Chlorohydrin - pharmacology Genes - drug effects Male Mice Microsomes, Liver - metabolism Mutation - drug effects Saccharomyces cerevisiae - drug effects Schizosaccharomyces - drug effects Vinyl Chloride - analogs & derivatives Vinyl Chloride - metabolism Vinyl Chloride - pharmacology Vinyl Compounds - pharmacology |
| title | Induction of gene mutations and gene conversions by vinyl chloride metabolites in yeast |
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