Comprehensive profiling of disease-relevant copy number aberrations for advanced clinical diagnostics of pediatric acute lymphoblastic leukemia

Acute lymphoblastic leukemia is the most common pediatric cancer characterized by a heterogeneous genomic landscape with copy number aberrations occurring at various stages of pathogenesis, disease progression, and treatment resistance. In this study, disease-relevant copy number aberrations were pr...

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Veröffentlicht in:	MODERN PATHOLOGY 2020-05, Vol.33 (5), p.812-824
Hauptverfasser:	Kiss, Richárd, Gángó, Ambrus, Benard-Slagter, Anne, Egyed, Bálint, Haltrich, Irén, Hegyi, Lajos, de Groot, Karel, Király, Péter Attila, Krizsán, Szilvia, Kajtár, Béla, Pikó, Henriett, Pajor, László, Vojcek, Ágnes, Matolcsy, András, Kovács, Gábor, Szuhai, Károly, Savola, Suvi, Bödör, Csaba, Alpár, Donát
Format:	Artikel
Sprache:	eng
Schlagworte:	45/23 45/77 631/1647/2217 631/67/69 692/699/67/1990/283/2125 692/699/67/2332 Acute lymphoblastic leukemia Adolescent Bone marrow Child Child, Preschool Copy number Cytogenetics Diagnosis Disease resistance DNA Copy Number Variations Female Gene Expression Profiling - methods Humans Infant Laboratory Medicine Leukemia Life Sciences & Biomedicine Lymphatic leukemia Lymphocytes B Lymphocytes T Male Medical prognosis Medicin och hälsovetenskap Medicine Medicine & Public Health Multiplex Polymerase Chain Reaction - methods Pathology Patients Pediatrics Precursor Cell Lymphoblastic Leukemia-Lymphoma - diagnosis Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics Science & Technology
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