Time-saving opportunities in knee osteoarthritis: T 2 mapping and structural imaging of the knee using a single 5-min MRI scan
To assess the discriminative power of a 5-min quantitative double-echo steady-state (qDESS) sequence for simultaneous T measurements of cartilage and meniscus, and structural knee osteoarthritis (OA) assessment, in a clinical OA population, using radiographic knee OA as reference standard. Fifty-thr...
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| Veröffentlicht in: | European radiology 2020-04, Vol.30 (4), p.2231 |
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| creator | Eijgenraam, Susanne M Chaudhari, Akshay S Reijman, Max Bierma-Zeinstra, Sita M A Hargreaves, Brian A Runhaar, Jos Heijboer, Frank W J Gold, Garry E Oei, Edwin H G |
| description | To assess the discriminative power of a 5-min quantitative double-echo steady-state (qDESS) sequence for simultaneous T
measurements of cartilage and meniscus, and structural knee osteoarthritis (OA) assessment, in a clinical OA population, using radiographic knee OA as reference standard.
Fifty-three subjects were included and divided over three groups based on radiographic and clinical knee OA: 20 subjects with no OA (Kellgren-Lawrence grade (KLG) 0), 18 with mild OA (KLG2), and 15 with moderate OA (KLG3). All patients underwent a 5-min qDESS scan. We measured T
relaxation times in four cartilage and four meniscus regions of interest (ROIs) and performed structural OA evaluation with the MRI Osteoarthritis Knee Score (MOAKS) using qDESS with multiplanar reformatting. Between-group differences in T
values and MOAKS were calculated using ANOVA. Correlations of the reference standard (i.e., radiographic knee OA) with T
and MOAKS were assessed with correlation analyses for ordinal variables.
In cartilage, mean T
values were 36.1 ± SD 4.3, 40.6 ± 5.9, and 47.1 ± 4.3 ms for no, mild, and moderate OA, respectively (p |
| doi_str_mv | 10.1007/s00330-019-06542-9 |
| format | Article |
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measurements of cartilage and meniscus, and structural knee osteoarthritis (OA) assessment, in a clinical OA population, using radiographic knee OA as reference standard.
Fifty-three subjects were included and divided over three groups based on radiographic and clinical knee OA: 20 subjects with no OA (Kellgren-Lawrence grade (KLG) 0), 18 with mild OA (KLG2), and 15 with moderate OA (KLG3). All patients underwent a 5-min qDESS scan. We measured T
relaxation times in four cartilage and four meniscus regions of interest (ROIs) and performed structural OA evaluation with the MRI Osteoarthritis Knee Score (MOAKS) using qDESS with multiplanar reformatting. Between-group differences in T
values and MOAKS were calculated using ANOVA. Correlations of the reference standard (i.e., radiographic knee OA) with T
and MOAKS were assessed with correlation analyses for ordinal variables.
In cartilage, mean T
values were 36.1 ± SD 4.3, 40.6 ± 5.9, and 47.1 ± 4.3 ms for no, mild, and moderate OA, respectively (p < 0.001). In menisci, mean T
values were 15 ± 3.6, 17.5 ± 3.8, and 20.6 ± 4.7 ms for no, mild, and moderate OA, respectively (p < 0.001). Statistically significant correlations were found between radiographic OA and T
and between radiographic OA and MOAKS in all ROIs (p < 0.05).
Quantitative T
and structural assessment of cartilage and meniscus, using a single 5-min qDESS scan, can distinguish between different grades of radiographic OA, demonstrating the potential of qDESS as an efficient tool for OA imaging.
• Quantitative T
values of cartilage and meniscus as well as structural assessment of the knee with a single 5-min quantitative double-echo steady-state (qDESS) scan can distinguish between different grades of knee osteoarthritis (OA). • Quantitative and structural qDESS-based measurements correlate significantly with the reference standard, radiographic degree of OA, for all cartilage and meniscus regions. • By providing quantitative measurements and diagnostic image quality in one rapid MRI scan, qDESS has great potential for application in large-scale clinical trials in knee OA.</description><identifier>EISSN: 1432-1084</identifier><identifier>DOI: 10.1007/s00330-019-06542-9</identifier><identifier>PMID: 31844957</identifier><language>eng</language><publisher>Germany</publisher><subject>Adult ; Aged ; Cartilage, Articular - diagnostic imaging ; Case-Control Studies ; Female ; Humans ; Knee Joint - diagnostic imaging ; Magnetic Resonance Imaging - methods ; Male ; Menisci, Tibial - diagnostic imaging ; Middle Aged ; Osteoarthritis, Knee - diagnostic imaging ; Severity of Illness Index ; Time Factors ; Young Adult</subject><ispartof>European radiology, 2020-04, Vol.30 (4), p.2231</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><orcidid>0000-0003-3727-3427</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27922,27923</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31844957$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Eijgenraam, Susanne M</creatorcontrib><creatorcontrib>Chaudhari, Akshay S</creatorcontrib><creatorcontrib>Reijman, Max</creatorcontrib><creatorcontrib>Bierma-Zeinstra, Sita M A</creatorcontrib><creatorcontrib>Hargreaves, Brian A</creatorcontrib><creatorcontrib>Runhaar, Jos</creatorcontrib><creatorcontrib>Heijboer, Frank W J</creatorcontrib><creatorcontrib>Gold, Garry E</creatorcontrib><creatorcontrib>Oei, Edwin H G</creatorcontrib><title>Time-saving opportunities in knee osteoarthritis: T 2 mapping and structural imaging of the knee using a single 5-min MRI scan</title><title>European radiology</title><addtitle>Eur Radiol</addtitle><description>To assess the discriminative power of a 5-min quantitative double-echo steady-state (qDESS) sequence for simultaneous T
measurements of cartilage and meniscus, and structural knee osteoarthritis (OA) assessment, in a clinical OA population, using radiographic knee OA as reference standard.
Fifty-three subjects were included and divided over three groups based on radiographic and clinical knee OA: 20 subjects with no OA (Kellgren-Lawrence grade (KLG) 0), 18 with mild OA (KLG2), and 15 with moderate OA (KLG3). All patients underwent a 5-min qDESS scan. We measured T
relaxation times in four cartilage and four meniscus regions of interest (ROIs) and performed structural OA evaluation with the MRI Osteoarthritis Knee Score (MOAKS) using qDESS with multiplanar reformatting. Between-group differences in T
values and MOAKS were calculated using ANOVA. Correlations of the reference standard (i.e., radiographic knee OA) with T
and MOAKS were assessed with correlation analyses for ordinal variables.
In cartilage, mean T
values were 36.1 ± SD 4.3, 40.6 ± 5.9, and 47.1 ± 4.3 ms for no, mild, and moderate OA, respectively (p < 0.001). In menisci, mean T
values were 15 ± 3.6, 17.5 ± 3.8, and 20.6 ± 4.7 ms for no, mild, and moderate OA, respectively (p < 0.001). Statistically significant correlations were found between radiographic OA and T
and between radiographic OA and MOAKS in all ROIs (p < 0.05).
Quantitative T
and structural assessment of cartilage and meniscus, using a single 5-min qDESS scan, can distinguish between different grades of radiographic OA, demonstrating the potential of qDESS as an efficient tool for OA imaging.
• Quantitative T
values of cartilage and meniscus as well as structural assessment of the knee with a single 5-min quantitative double-echo steady-state (qDESS) scan can distinguish between different grades of knee osteoarthritis (OA). • Quantitative and structural qDESS-based measurements correlate significantly with the reference standard, radiographic degree of OA, for all cartilage and meniscus regions. • By providing quantitative measurements and diagnostic image quality in one rapid MRI scan, qDESS has great potential for application in large-scale clinical trials in knee OA.</description><subject>Adult</subject><subject>Aged</subject><subject>Cartilage, Articular - diagnostic imaging</subject><subject>Case-Control Studies</subject><subject>Female</subject><subject>Humans</subject><subject>Knee Joint - diagnostic imaging</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Male</subject><subject>Menisci, Tibial - diagnostic imaging</subject><subject>Middle Aged</subject><subject>Osteoarthritis, Knee - diagnostic imaging</subject><subject>Severity of Illness Index</subject><subject>Time Factors</subject><subject>Young Adult</subject><issn>1432-1084</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1kM1KAzEcxIMgtlZfwIPkBaL_fG2y3qT4UagIUs8lu0na1e5uSLKCF5_dbaungWHmxzAIXVG4oQDqNgFwDgRoSaCQgpHyBE2p4IxQ0GKCzlP6AICSCnWGJpxqIUqppuhn1bSOJPPVdBvch9DHPHRNblzCTYc_O-dwn7LrTczbOPrpDq8ww60JYd8wncUpx6HOQzQ73LRmcwB5nLfuWB_SIYj3snNYknYEv7wtcKpNd4FOvdkld_mnM_T--LCaP5Pl69Nifr8kYZyfiWGiUt45yZUEU3gmQFqhdKWcdZVkRSV46b2UunRaW-DK8kJDzS2lNfOCz9D1kRuGqnV2HeI4NX6v_4_gvzHIX38</recordid><startdate>202004</startdate><enddate>202004</enddate><creator>Eijgenraam, Susanne M</creator><creator>Chaudhari, Akshay S</creator><creator>Reijman, Max</creator><creator>Bierma-Zeinstra, Sita M A</creator><creator>Hargreaves, Brian A</creator><creator>Runhaar, Jos</creator><creator>Heijboer, Frank W J</creator><creator>Gold, Garry E</creator><creator>Oei, Edwin H G</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><orcidid>https://orcid.org/0000-0003-3727-3427</orcidid></search><sort><creationdate>202004</creationdate><title>Time-saving opportunities in knee osteoarthritis: T 2 mapping and structural imaging of the knee using a single 5-min MRI scan</title><author>Eijgenraam, Susanne M ; Chaudhari, Akshay S ; Reijman, Max ; Bierma-Zeinstra, Sita M A ; Hargreaves, Brian A ; Runhaar, Jos ; Heijboer, Frank W J ; Gold, Garry E ; Oei, Edwin H G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p108t-a24b7fee53750a6f2405d478b7edeb526b439ff5589e88d037d3680c3d11c2f43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Cartilage, Articular - diagnostic imaging</topic><topic>Case-Control Studies</topic><topic>Female</topic><topic>Humans</topic><topic>Knee Joint - diagnostic imaging</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Male</topic><topic>Menisci, Tibial - diagnostic imaging</topic><topic>Middle Aged</topic><topic>Osteoarthritis, Knee - diagnostic imaging</topic><topic>Severity of Illness Index</topic><topic>Time Factors</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Eijgenraam, Susanne M</creatorcontrib><creatorcontrib>Chaudhari, Akshay S</creatorcontrib><creatorcontrib>Reijman, Max</creatorcontrib><creatorcontrib>Bierma-Zeinstra, Sita M A</creatorcontrib><creatorcontrib>Hargreaves, Brian A</creatorcontrib><creatorcontrib>Runhaar, Jos</creatorcontrib><creatorcontrib>Heijboer, Frank W J</creatorcontrib><creatorcontrib>Gold, Garry E</creatorcontrib><creatorcontrib>Oei, Edwin H G</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>European radiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Eijgenraam, Susanne M</au><au>Chaudhari, Akshay S</au><au>Reijman, Max</au><au>Bierma-Zeinstra, Sita M A</au><au>Hargreaves, Brian A</au><au>Runhaar, Jos</au><au>Heijboer, Frank W J</au><au>Gold, Garry E</au><au>Oei, Edwin H G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Time-saving opportunities in knee osteoarthritis: T 2 mapping and structural imaging of the knee using a single 5-min MRI scan</atitle><jtitle>European radiology</jtitle><addtitle>Eur Radiol</addtitle><date>2020-04</date><risdate>2020</risdate><volume>30</volume><issue>4</issue><spage>2231</spage><pages>2231-</pages><eissn>1432-1084</eissn><abstract>To assess the discriminative power of a 5-min quantitative double-echo steady-state (qDESS) sequence for simultaneous T
measurements of cartilage and meniscus, and structural knee osteoarthritis (OA) assessment, in a clinical OA population, using radiographic knee OA as reference standard.
Fifty-three subjects were included and divided over three groups based on radiographic and clinical knee OA: 20 subjects with no OA (Kellgren-Lawrence grade (KLG) 0), 18 with mild OA (KLG2), and 15 with moderate OA (KLG3). All patients underwent a 5-min qDESS scan. We measured T
relaxation times in four cartilage and four meniscus regions of interest (ROIs) and performed structural OA evaluation with the MRI Osteoarthritis Knee Score (MOAKS) using qDESS with multiplanar reformatting. Between-group differences in T
values and MOAKS were calculated using ANOVA. Correlations of the reference standard (i.e., radiographic knee OA) with T
and MOAKS were assessed with correlation analyses for ordinal variables.
In cartilage, mean T
values were 36.1 ± SD 4.3, 40.6 ± 5.9, and 47.1 ± 4.3 ms for no, mild, and moderate OA, respectively (p < 0.001). In menisci, mean T
values were 15 ± 3.6, 17.5 ± 3.8, and 20.6 ± 4.7 ms for no, mild, and moderate OA, respectively (p < 0.001). Statistically significant correlations were found between radiographic OA and T
and between radiographic OA and MOAKS in all ROIs (p < 0.05).
Quantitative T
and structural assessment of cartilage and meniscus, using a single 5-min qDESS scan, can distinguish between different grades of radiographic OA, demonstrating the potential of qDESS as an efficient tool for OA imaging.
• Quantitative T
values of cartilage and meniscus as well as structural assessment of the knee with a single 5-min quantitative double-echo steady-state (qDESS) scan can distinguish between different grades of knee osteoarthritis (OA). • Quantitative and structural qDESS-based measurements correlate significantly with the reference standard, radiographic degree of OA, for all cartilage and meniscus regions. • By providing quantitative measurements and diagnostic image quality in one rapid MRI scan, qDESS has great potential for application in large-scale clinical trials in knee OA.</abstract><cop>Germany</cop><pmid>31844957</pmid><doi>10.1007/s00330-019-06542-9</doi><orcidid>https://orcid.org/0000-0003-3727-3427</orcidid><oa>free_for_read</oa></addata></record> |
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| language | eng |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Adult Aged Cartilage, Articular - diagnostic imaging Case-Control Studies Female Humans Knee Joint - diagnostic imaging Magnetic Resonance Imaging - methods Male Menisci, Tibial - diagnostic imaging Middle Aged Osteoarthritis, Knee - diagnostic imaging Severity of Illness Index Time Factors Young Adult |
| title | Time-saving opportunities in knee osteoarthritis: T 2 mapping and structural imaging of the knee using a single 5-min MRI scan |
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