Chemical synthesis of Shiga toxin subunit B using a next-generation traceless "helping hand" solubilizing tag

The application of solid-phase peptide synthesis and native chemical ligation in chemical protein synthesis (CPS) has enabled access to synthetic proteins that cannot be produced recombinantly, such as site-specific post-translationally modified or mirror-image proteins (D-proteins). However, CPS is...

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Veröffentlicht in:	Organic & biomolecular chemistry 2019-12, Vol.17 (48), p.1237-1244
Hauptverfasser:	Fulcher, James M, Petersen, Mark E, Giesler, Riley J, Cruz, Zachary S, Eckert, Debra M, Francis, J. Nicholas, Kawamoto, Eric M, Jacobsen, Michael T, Kay, Michael S
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Amino acids Arginine - chemistry Chemical synthesis Cyclohexanones - chemistry Hydroxylamine Hydroxylamine - chemistry Intermediates Lysine - chemistry Organic chemistry Peptide synthesis Peptides Peptides - chemistry Post-translation Protein biosynthesis Protein Subunits - chemical synthesis Protein synthesis Proteins Shiga toxin Shiga Toxin - chemical synthesis Solid phases Solid-Phase Synthesis Techniques - methods Solubility Toxins
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