Chemotaxonomic studies on natural population of Gloriosa superba (L.) collected from Gangetic plain (India) and their invitro antigout activity for the identification of elite germplasm(s)
Gloriosa superba L. (Colchicaceae) is used in the treatment of gout and rheumatism as a traditional medicine dates back to 1810. It has also been used as ethnobotanical and folklore medicine to induce abortion/vaginal poison. The present study was carried out to identify the chemical variation exist...
Gespeichert in:
| Veröffentlicht in: | Journal of ethnopharmacology 2020-03, Vol.249, p.112387, Article 112387 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | 112387 |
| container_title | Journal of ethnopharmacology |
| container_volume | 249 |
| creator | Misra, Ankita Srivastava, Sharad Kumar, Sanjeev Shukla, Pushpendra Kumar Kumar, Manish Agrawal, Pawan Kumar Barik, Saroj Kanta |
| description | Gloriosa superba L. (Colchicaceae) is used in the treatment of gout and rheumatism as a traditional medicine dates back to 1810. It has also been used as ethnobotanical and folklore medicine to induce abortion/vaginal poison.
The present study was carried out to identify the chemical variation existing in the major alkaloid metabolite (colchicine) in a threatened species, Gloriosa superba L. and is correlated with invitro antigout activity.
The samples (tuber) were collected from their natural locations in Gangetic plain of India. HPLC-PDA quantification of colchicine was done on C18 column at 245 nm and invitro antigout activity was analyzed by inhibition of protein denaturation, DPPH and Hydroxyl radical scavenging assay.
The colchicine content within the 29 samples ranges from 0.021 to 0.665% and the maximum contents was in NBG-10 from Kanth (U.P). Such high colchicine (0.665%) containing natural population of G. superba is reported for the first time in Indian population. Four chemotypes viz. NBG-10, NBG-120, NBG-126 and NBG-88 were selected on the basis of colchicine content for invitro antigout activity. NBG-10 was separated from rest of the population exhibiting the most promising activity with high colchicine content.
The outcomes will be helpful in the identification of elite chemotype for herbal product development and quality check of metabolites in raw material. The study will also support the site-specific commercial cultivation to meet out the industrial demand as well as income generation to farmers.
[Display omitted] |
| doi_str_mv | 10.1016/j.jep.2019.112387 |
| format | Article |
| fullrecord | <record><control><sourceid>pubmed_cross</sourceid><recordid>TN_cdi_pubmed_primary_31756449</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0378874119305653</els_id><sourcerecordid>31756449</sourcerecordid><originalsourceid>FETCH-LOGICAL-c353t-265a4a6e358ab0914b427d65f2a2c5656edb397f1e468fa47a7d1a710368d5873</originalsourceid><addsrcrecordid>eNqNkcGO0zAURS0EYsrAB7BBXrZCKXZsx6lYoWimjFSJDawjx37puErsyHZmmH_j43DJ0CViZev53vvkexB6T8mWElp9Om1PMG1LQndbSktWyxdoRWtZFlJI9hKtCJN1UUtOr9CbGE-EEEk5eY2uGJWi4ny3Qr-aexh9Uj-986PVOKbZWIjYO-xUmoMa8OSneVDJ5pHv8X7wwfqocJwnCJ3C68N2g7UfBtAJDO6DH_FeuSOkHDcNyjq8vnPGqg1WzuB0DzZg6x5sCj5Pkj36OWGlk82jJ9z7cNZgayC_9VZfNsNgE-AjhDGnxnEdN2_Rq14NEd49n9fox-3N9-Zrcfi2v2u-HArNBEtFWQnFVQVM1KojO8o7XkpTib5UpRaVqMB0bCd7Cryqe8WlkoYqSQmraiNqya4RXXJ18DEG6Nsp2FGFp5aS9kyiPbWZRHsm0S4ksufD4pnmbgRzcfytPgs-LoJH6HwftQWn4SLLrAQVnJYy30qR1fX_qxub_rTW-NmlbP28WCFX9GAhtM92Y0Nm1hpv__GP35ajvX8</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Chemotaxonomic studies on natural population of Gloriosa superba (L.) collected from Gangetic plain (India) and their invitro antigout activity for the identification of elite germplasm(s)</title><source>Web of Science - Science Citation Index Expanded - 2020<img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" /></source><source>Access via ScienceDirect (Elsevier)</source><creator>Misra, Ankita ; Srivastava, Sharad ; Kumar, Sanjeev ; Shukla, Pushpendra Kumar ; Kumar, Manish ; Agrawal, Pawan Kumar ; Barik, Saroj Kanta</creator><creatorcontrib>Misra, Ankita ; Srivastava, Sharad ; Kumar, Sanjeev ; Shukla, Pushpendra Kumar ; Kumar, Manish ; Agrawal, Pawan Kumar ; Barik, Saroj Kanta</creatorcontrib><description>Gloriosa superba L. (Colchicaceae) is used in the treatment of gout and rheumatism as a traditional medicine dates back to 1810. It has also been used as ethnobotanical and folklore medicine to induce abortion/vaginal poison.
The present study was carried out to identify the chemical variation existing in the major alkaloid metabolite (colchicine) in a threatened species, Gloriosa superba L. and is correlated with invitro antigout activity.
The samples (tuber) were collected from their natural locations in Gangetic plain of India. HPLC-PDA quantification of colchicine was done on C18 column at 245 nm and invitro antigout activity was analyzed by inhibition of protein denaturation, DPPH and Hydroxyl radical scavenging assay.
The colchicine content within the 29 samples ranges from 0.021 to 0.665% and the maximum contents was in NBG-10 from Kanth (U.P). Such high colchicine (0.665%) containing natural population of G. superba is reported for the first time in Indian population. Four chemotypes viz. NBG-10, NBG-120, NBG-126 and NBG-88 were selected on the basis of colchicine content for invitro antigout activity. NBG-10 was separated from rest of the population exhibiting the most promising activity with high colchicine content.
The outcomes will be helpful in the identification of elite chemotype for herbal product development and quality check of metabolites in raw material. The study will also support the site-specific commercial cultivation to meet out the industrial demand as well as income generation to farmers.
[Display omitted]</description><identifier>ISSN: 0378-8741</identifier><identifier>EISSN: 1872-7573</identifier><identifier>DOI: 10.1016/j.jep.2019.112387</identifier><identifier>PMID: 31756449</identifier><language>eng</language><publisher>CLARE: Elsevier B.V</publisher><subject>Chemistry, Medicinal ; Integrative & Complementary Medicine ; Life Sciences & Biomedicine ; Pharmacology & Pharmacy ; Plant Sciences ; Science & Technology</subject><ispartof>Journal of ethnopharmacology, 2020-03, Vol.249, p.112387, Article 112387</ispartof><rights>2019 Elsevier B.V.</rights><rights>Copyright © 2019 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>14</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000515412700025</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c353t-265a4a6e358ab0914b427d65f2a2c5656edb397f1e468fa47a7d1a710368d5873</citedby><cites>FETCH-LOGICAL-c353t-265a4a6e358ab0914b427d65f2a2c5656edb397f1e468fa47a7d1a710368d5873</cites><orcidid>0000-0001-6794-9657 ; 0000-0002-1795-9539</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jep.2019.112387$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27929,27930,28253,46000</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31756449$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Misra, Ankita</creatorcontrib><creatorcontrib>Srivastava, Sharad</creatorcontrib><creatorcontrib>Kumar, Sanjeev</creatorcontrib><creatorcontrib>Shukla, Pushpendra Kumar</creatorcontrib><creatorcontrib>Kumar, Manish</creatorcontrib><creatorcontrib>Agrawal, Pawan Kumar</creatorcontrib><creatorcontrib>Barik, Saroj Kanta</creatorcontrib><title>Chemotaxonomic studies on natural population of Gloriosa superba (L.) collected from Gangetic plain (India) and their invitro antigout activity for the identification of elite germplasm(s)</title><title>Journal of ethnopharmacology</title><addtitle>J ETHNOPHARMACOL</addtitle><addtitle>J Ethnopharmacol</addtitle><description>Gloriosa superba L. (Colchicaceae) is used in the treatment of gout and rheumatism as a traditional medicine dates back to 1810. It has also been used as ethnobotanical and folklore medicine to induce abortion/vaginal poison.
The present study was carried out to identify the chemical variation existing in the major alkaloid metabolite (colchicine) in a threatened species, Gloriosa superba L. and is correlated with invitro antigout activity.
The samples (tuber) were collected from their natural locations in Gangetic plain of India. HPLC-PDA quantification of colchicine was done on C18 column at 245 nm and invitro antigout activity was analyzed by inhibition of protein denaturation, DPPH and Hydroxyl radical scavenging assay.
The colchicine content within the 29 samples ranges from 0.021 to 0.665% and the maximum contents was in NBG-10 from Kanth (U.P). Such high colchicine (0.665%) containing natural population of G. superba is reported for the first time in Indian population. Four chemotypes viz. NBG-10, NBG-120, NBG-126 and NBG-88 were selected on the basis of colchicine content for invitro antigout activity. NBG-10 was separated from rest of the population exhibiting the most promising activity with high colchicine content.
The outcomes will be helpful in the identification of elite chemotype for herbal product development and quality check of metabolites in raw material. The study will also support the site-specific commercial cultivation to meet out the industrial demand as well as income generation to farmers.
[Display omitted]</description><subject>Chemistry, Medicinal</subject><subject>Integrative & Complementary Medicine</subject><subject>Life Sciences & Biomedicine</subject><subject>Pharmacology & Pharmacy</subject><subject>Plant Sciences</subject><subject>Science & Technology</subject><issn>0378-8741</issn><issn>1872-7573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>AOWDO</sourceid><recordid>eNqNkcGO0zAURS0EYsrAB7BBXrZCKXZsx6lYoWimjFSJDawjx37puErsyHZmmH_j43DJ0CViZev53vvkexB6T8mWElp9Om1PMG1LQndbSktWyxdoRWtZFlJI9hKtCJN1UUtOr9CbGE-EEEk5eY2uGJWi4ny3Qr-aexh9Uj-986PVOKbZWIjYO-xUmoMa8OSneVDJ5pHv8X7wwfqocJwnCJ3C68N2g7UfBtAJDO6DH_FeuSOkHDcNyjq8vnPGqg1WzuB0DzZg6x5sCj5Pkj36OWGlk82jJ9z7cNZgayC_9VZfNsNgE-AjhDGnxnEdN2_Rq14NEd49n9fox-3N9-Zrcfi2v2u-HArNBEtFWQnFVQVM1KojO8o7XkpTib5UpRaVqMB0bCd7Cryqe8WlkoYqSQmraiNqya4RXXJ18DEG6Nsp2FGFp5aS9kyiPbWZRHsm0S4ksufD4pnmbgRzcfytPgs-LoJH6HwftQWn4SLLrAQVnJYy30qR1fX_qxub_rTW-NmlbP28WCFX9GAhtM92Y0Nm1hpv__GP35ajvX8</recordid><startdate>20200301</startdate><enddate>20200301</enddate><creator>Misra, Ankita</creator><creator>Srivastava, Sharad</creator><creator>Kumar, Sanjeev</creator><creator>Shukla, Pushpendra Kumar</creator><creator>Kumar, Manish</creator><creator>Agrawal, Pawan Kumar</creator><creator>Barik, Saroj Kanta</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>AOWDO</scope><scope>BLEPL</scope><scope>DTL</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><orcidid>https://orcid.org/0000-0001-6794-9657</orcidid><orcidid>https://orcid.org/0000-0002-1795-9539</orcidid></search><sort><creationdate>20200301</creationdate><title>Chemotaxonomic studies on natural population of Gloriosa superba (L.) collected from Gangetic plain (India) and their invitro antigout activity for the identification of elite germplasm(s)</title><author>Misra, Ankita ; Srivastava, Sharad ; Kumar, Sanjeev ; Shukla, Pushpendra Kumar ; Kumar, Manish ; Agrawal, Pawan Kumar ; Barik, Saroj Kanta</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c353t-265a4a6e358ab0914b427d65f2a2c5656edb397f1e468fa47a7d1a710368d5873</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Chemistry, Medicinal</topic><topic>Integrative & Complementary Medicine</topic><topic>Life Sciences & Biomedicine</topic><topic>Pharmacology & Pharmacy</topic><topic>Plant Sciences</topic><topic>Science & Technology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Misra, Ankita</creatorcontrib><creatorcontrib>Srivastava, Sharad</creatorcontrib><creatorcontrib>Kumar, Sanjeev</creatorcontrib><creatorcontrib>Shukla, Pushpendra Kumar</creatorcontrib><creatorcontrib>Kumar, Manish</creatorcontrib><creatorcontrib>Agrawal, Pawan Kumar</creatorcontrib><creatorcontrib>Barik, Saroj Kanta</creatorcontrib><collection>Web of Science - Science Citation Index Expanded - 2020</collection><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Journal of ethnopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Misra, Ankita</au><au>Srivastava, Sharad</au><au>Kumar, Sanjeev</au><au>Shukla, Pushpendra Kumar</au><au>Kumar, Manish</au><au>Agrawal, Pawan Kumar</au><au>Barik, Saroj Kanta</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chemotaxonomic studies on natural population of Gloriosa superba (L.) collected from Gangetic plain (India) and their invitro antigout activity for the identification of elite germplasm(s)</atitle><jtitle>Journal of ethnopharmacology</jtitle><stitle>J ETHNOPHARMACOL</stitle><addtitle>J Ethnopharmacol</addtitle><date>2020-03-01</date><risdate>2020</risdate><volume>249</volume><spage>112387</spage><pages>112387-</pages><artnum>112387</artnum><issn>0378-8741</issn><eissn>1872-7573</eissn><abstract>Gloriosa superba L. (Colchicaceae) is used in the treatment of gout and rheumatism as a traditional medicine dates back to 1810. It has also been used as ethnobotanical and folklore medicine to induce abortion/vaginal poison.
The present study was carried out to identify the chemical variation existing in the major alkaloid metabolite (colchicine) in a threatened species, Gloriosa superba L. and is correlated with invitro antigout activity.
The samples (tuber) were collected from their natural locations in Gangetic plain of India. HPLC-PDA quantification of colchicine was done on C18 column at 245 nm and invitro antigout activity was analyzed by inhibition of protein denaturation, DPPH and Hydroxyl radical scavenging assay.
The colchicine content within the 29 samples ranges from 0.021 to 0.665% and the maximum contents was in NBG-10 from Kanth (U.P). Such high colchicine (0.665%) containing natural population of G. superba is reported for the first time in Indian population. Four chemotypes viz. NBG-10, NBG-120, NBG-126 and NBG-88 were selected on the basis of colchicine content for invitro antigout activity. NBG-10 was separated from rest of the population exhibiting the most promising activity with high colchicine content.
The outcomes will be helpful in the identification of elite chemotype for herbal product development and quality check of metabolites in raw material. The study will also support the site-specific commercial cultivation to meet out the industrial demand as well as income generation to farmers.
[Display omitted]</abstract><cop>CLARE</cop><pub>Elsevier B.V</pub><pmid>31756449</pmid><doi>10.1016/j.jep.2019.112387</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0001-6794-9657</orcidid><orcidid>https://orcid.org/0000-0002-1795-9539</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0378-8741 |
| ispartof | Journal of ethnopharmacology, 2020-03, Vol.249, p.112387, Article 112387 |
| issn | 0378-8741 1872-7573 |
| language | eng |
| recordid | cdi_pubmed_primary_31756449 |
| source | Web of Science - Science Citation Index Expanded - 2020<img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" />; Access via ScienceDirect (Elsevier) |
| subjects | Chemistry, Medicinal Integrative & Complementary Medicine Life Sciences & Biomedicine Pharmacology & Pharmacy Plant Sciences Science & Technology |
| title | Chemotaxonomic studies on natural population of Gloriosa superba (L.) collected from Gangetic plain (India) and their invitro antigout activity for the identification of elite germplasm(s) |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-12T13%3A42%3A16IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-pubmed_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Chemotaxonomic%20studies%20on%20natural%20population%20of%20Gloriosa%20superba%20(L.)%20collected%20from%20Gangetic%20plain%20(India)%20and%20their%20invitro%20antigout%20activity%20for%20the%20identification%20of%20elite%20germplasm(s)&rft.jtitle=Journal%20of%20ethnopharmacology&rft.au=Misra,%20Ankita&rft.date=2020-03-01&rft.volume=249&rft.spage=112387&rft.pages=112387-&rft.artnum=112387&rft.issn=0378-8741&rft.eissn=1872-7573&rft_id=info:doi/10.1016/j.jep.2019.112387&rft_dat=%3Cpubmed_cross%3E31756449%3C/pubmed_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/31756449&rft_els_id=S0378874119305653&rfr_iscdi=true |