Tryptophan-glucosamine conjugates modulate tau-derived PHF6 aggregation at low concentrations

Glycosylation of amyloidogenic proteins enhances their solubility and reduces propensity for aggregation. We therefore, prepared tryptophan-glucosamine conjugates to modulate aggregation of tau-derived PHF6-peptide. Combined in vitro and in silico approaches indicated that these conjugates inhibited...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2019-12, Vol.55 (97), p.14621-14624
Hauptverfasser:	Paul, Ashim, Li, Wen-Hao, Viswanathan, Guru KrishnaKumar, Arad, Elad, Mohapatra, Satabdee, Li, Gao, Jelinek, Raz, Gazit, Ehud, Li, Yan-Mei, Segal, Daniel
Format:	Artikel
Sprache:	eng
Schlagworte:	Agglomeration Conjugates Low concentrations Oligomerization Tryptophan
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!