Minocycline Relieves Depressive-Like Behaviors in Rats With Bone Cancer Pain by Inhibiting Microglia Activation in Hippocampus

Pain and depression are highly prevalent symptoms in cancer patients. They tend to occur simultaneously and affect each other and share biological pathways and neurotransmitters. In this study, we investigated the roles of microglia in the hippocampus in the comorbidity of bone cancer pain and depre...

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Veröffentlicht in:	Anesthesia and analgesia 2019-12, Vol.129 (6), p.1733
Hauptverfasser:	Dai, Jiajia, Ding, Zhuofeng, Zhang, Jie, Xu, Wei, Guo, Qulian, Zou, Wangyuan, Xiong, Yunchuan, Weng, Yingqi, Yang, Yong, Chen, Sisi, Zhang, Jun-Ming, Song, Zongbin
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bone Neoplasms - drug therapy Bone Neoplasms - metabolism Bone Neoplasms - psychology Cancer Pain - drug therapy Cancer Pain - metabolism Cancer Pain - psychology Depression - drug therapy Depression - metabolism Depression - psychology Female Hippocampus - drug effects Hippocampus - metabolism Inflammation Mediators - antagonists & inhibitors Inflammation Mediators - metabolism Injections, Intraventricular Microglia - drug effects Microglia - metabolism Minocycline - administration & dosage Rats Rats, Wistar
Online-Zugang:	Volltext
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