Expression of Tumor-mediated CD137 ligand in human colon cancer indicates dual signaling effects

CD137-targeting immune therapy, which activates anti-tumor T effector cell responses, seems to be an attractive concept in clinical oncology. Recent evidence has demonstrated that tumor cells besides T cells and antigen-presenting cells are able to express CD137 and CD137L. Here we aimed to identify...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Oncoimmunology 2019-12, Vol.8 (12), p.e1651622-e1651622
Hauptverfasser:	Grimmig, Tanja, Gasser, Martin, Moench, Romana, Zhu, Lang-Jing, Nawalaniec, Karol, Callies, Simone, Wagner, Martin, Polat, Buelent, Mothi, Suraj Sarvode, Luo, Yueming, Ribas, Carmen M., Malafaia, Osvaldo, Hsiao, Li-Li, Waaga-Gasser, Ana Maria
Format:	Artikel
Sprache:	eng
Schlagworte:	anti-tumor immune response CD137/CD137L pathway co-stimulatory signaling colorectal cancer Original Research tumor escape mechanism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!