Combinatorial Oxytocin Neuropharmacology in Social Cognition

The efficacy and reliability of using intranasal oxytocin (OT) to clinically enhance social functions remains undependable. We discuss the potential benefit of concurrent administration of OT and naloxone (NAL) to robustly modulate social behavior. We further suggest that combinatorial neuropharmaco...

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Veröffentlicht in:	Trends in cognitive sciences 2020-01, Vol.24 (1), p.8-12
Hauptverfasser:	Fan, Siqi, Weinberg-Wolf, Hannah, Piva, Matthew, Dal Monte, Olga, Chang, Steve W.C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Autism Spectrum Disorder - therapy autism spectrum disorders Behavioral Sciences combinatorial neuropharmacology Humans Life Sciences & Biomedicine naloxone Neuropharmacology Neurosciences Neurosciences & Neurology oxytocin Oxytocin - administration & dosage Oxytocin - therapeutic use Psychology Psychology, Experimental Reproducibility of Results Science & Technology serotonin Social Behavior Social Cognition Social Sciences
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Beschreibung
Zusammenfassung:	The efficacy and reliability of using intranasal oxytocin (OT) to clinically enhance social functions remains undependable. We discuss the potential benefit of concurrent administration of OT and naloxone (NAL) to robustly modulate social behavior. We further suggest that combinatorial neuropharmacology approaches should exploit the interactions between OT and serotonin to regulate social functions.
ISSN:	1364-6613 1879-307X
DOI:	10.1016/j.tics.2019.10.004