Alpha-asarone improves cognitive function of aged rats by alleviating neuronal excitotoxicity via GABA A receptors

Alzheimer's disease (AD), the most common form of dementia, still lacks effective treatment at present. Alpha-asarone (ASA) is the major compound isolated from the Chinese medicinal herb Acorus gramineus. It has been reported to enhance cognitive function in rodent models, yet its mechanism was...

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Veröffentlicht in:	Neuropharmacology 2020-01, Vol.162, p.107843
Hauptverfasser:	Chen, Yu, Gao, Xiaofeng, Liu, Qi, Zeng, Lili, Zhang, Kun, Mu, Keman, Zhang, Di, Zou, Huixi, Wu, Nan, Ou, Jierui, Wang, Qiantao, Mao, Shengjun
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging - metabolism Aging - psychology Allosteric Regulation Amyloid beta-Peptides - drug effects Amyloid beta-Peptides - metabolism Animals Anisoles - pharmacology Calcium - metabolism Cognition - drug effects Glutamic Acid - metabolism Hippocampus - cytology Hippocampus - drug effects Hippocampus - metabolism Molecular Docking Simulation Molecular Dynamics Simulation Neurons - drug effects Neurons - metabolism Neuroprotective Agents - pharmacology Patch-Clamp Techniques Peptide Fragments - drug effects Peptide Fragments - metabolism Rats Receptors, GABA-A - drug effects Receptors, GABA-A - metabolism Spatial Memory - drug effects
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