Creatinine‐to‐bodyweight ratio is a predictor of incident non‐alcoholic fatty liver disease: A population‐based longitudinal study
Aim Serum creatinine (Cre) is used as a surrogate marker of muscle mass. We investigated the impact of the Cre‐to‐bodyweight (BW) ratio (Cre/BW) on incident non‐alcoholic fatty liver disease (NAFLD). Methods Fatty liver disease was diagnosed by abdominal ultrasonography. In this historical cohort st...
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| Veröffentlicht in: | Hepatology research 2020-01, Vol.50 (1), p.57-66 |
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| creator | Okamura, Takuro Hashimoto, Yoshitaka Hamaguchi, Masahide Obora, Akihiro Kojima, Takao Fukui, Michiaki |
| description | Aim
Serum creatinine (Cre) is used as a surrogate marker of muscle mass. We investigated the impact of the Cre‐to‐bodyweight (BW) ratio (Cre/BW) on incident non‐alcoholic fatty liver disease (NAFLD).
Methods
Fatty liver disease was diagnosed by abdominal ultrasonography. In this historical cohort study of 13 728 participants (6397 men and 7331 women), we divided the participants into two groups by sex and into quartiles according to Cre (mg/dL)/BW (kg; Q1–4). We carried out Cox proportional hazard models, adjusting for age, alanine aminotransferase, fasting plasma glucose, systolic blood pressure, alcohol consumption, smoking status, and exercise.
Results
During the 5.1‐year follow up for men and 6.0‐year follow up for women, 2497 participants (1696 men, 801 women) developed NAFLD. The 4000‐days cumulative incidence rates of FLD for men and women were 29.6% and 16.6% in Q1, 28.2% and 10.6% in Q2, 25.5% and 8.8% in Q3, and 22.7% and 7.7% in Q4, respectively. The hazard ratios of incident NAFLD in Q1 (Cre/BW [×100]: men |
| doi_str_mv | 10.1111/hepr.13429 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmed_primary_31692179</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2312547826</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4479-4aafa41d5d90ed9a4bdacbced381e8e6530ffe15b392899b74c796d1543042da3</originalsourceid><addsrcrecordid>eNqNkU1rFTEUhgdR7Idu_AEScCPK1HzNR7orQ7VCQREFd0MmOdObkpuMScYyO9dd-Rv9JWZ6r124ELNIDsnznvOStyieEXxC8nqzgSmcEMapeFAckrahJWb868Ncs7Yua8brg-IoxmuMSYMpf1wcMFILShpxWNx2AWQyzjj49eNn8nkbvF5uwFxtEgr5ySMTkURTAG1U8gH5ERmnjAaXkPMuK6RVfuOtUWiUKS3Imu8QkDYRZIRTdIYmP8127bXSQ77UyHp3ZdKsjZMWxVwsT4pHo7QRnu7P4-LL2_PP3UV5-eHd--7sslScN6LkUo6SE11pgUELyQct1aBAs5ZAC3XF8DgCqQYmaCvE0HDViFqTijPMqZbsuHi56zsF_22GmPqtiQqslQ78HHvKCK1409I6oy_-Qq_9HLLjleL5x3Hbkky92lEq-BgDjP0UzFaGpSe4XxPq14T6u4Qy_Hzfch62oO_RP5Fk4PUOuIHBj1EZcAruMYwxFzUndZUrvM5u_5_uTLoLofOzS1lK9lJjYfmH5_7i_OOnnfvfyf7DCw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2343420881</pqid></control><display><type>article</type><title>Creatinine‐to‐bodyweight ratio is a predictor of incident non‐alcoholic fatty liver disease: A population‐based longitudinal study</title><source>Access via Wiley Online Library</source><source>Web of Science - Science Citation Index Expanded - 2020<img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" /></source><source>Web of Science - Social Sciences Citation Index – 2020<img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" /></source><creator>Okamura, Takuro ; Hashimoto, Yoshitaka ; Hamaguchi, Masahide ; Obora, Akihiro ; Kojima, Takao ; Fukui, Michiaki</creator><creatorcontrib>Okamura, Takuro ; Hashimoto, Yoshitaka ; Hamaguchi, Masahide ; Obora, Akihiro ; Kojima, Takao ; Fukui, Michiaki</creatorcontrib><description>Aim
Serum creatinine (Cre) is used as a surrogate marker of muscle mass. We investigated the impact of the Cre‐to‐bodyweight (BW) ratio (Cre/BW) on incident non‐alcoholic fatty liver disease (NAFLD).
Methods
Fatty liver disease was diagnosed by abdominal ultrasonography. In this historical cohort study of 13 728 participants (6397 men and 7331 women), we divided the participants into two groups by sex and into quartiles according to Cre (mg/dL)/BW (kg; Q1–4). We carried out Cox proportional hazard models, adjusting for age, alanine aminotransferase, fasting plasma glucose, systolic blood pressure, alcohol consumption, smoking status, and exercise.
Results
During the 5.1‐year follow up for men and 6.0‐year follow up for women, 2497 participants (1696 men, 801 women) developed NAFLD. The 4000‐days cumulative incidence rates of FLD for men and women were 29.6% and 16.6% in Q1, 28.2% and 10.6% in Q2, 25.5% and 8.8% in Q3, and 22.7% and 7.7% in Q4, respectively. The hazard ratios of incident NAFLD in Q1 (Cre/BW [×100]: men <1.28; women <1.17) were 1.89 (95% confidence interval 1.64–2.17, P < 0.001) in men and 2.96 (2.42–3.62, P < 0.001) in women, compared with Q4 (Cre/BW [×100]: men ≥1.61; women ≥1.51).
Conclusions
A low Cre/BW is associated with an increased risk of NAFLD. Screening Cre/BW can be used to identify individuals who are at high risk of NAFLD.</description><identifier>ISSN: 1386-6346</identifier><identifier>EISSN: 1872-034X</identifier><identifier>DOI: 10.1111/hepr.13429</identifier><identifier>PMID: 31692179</identifier><language>eng</language><publisher>HOBOKEN: Wiley</publisher><subject>Alanine ; Alanine transaminase ; Blood pressure ; Cohort analysis ; cohort study ; Creatinine ; creatinine‐to‐bodyweight ratio ; epidemiology ; Fatty liver ; fatty liver disease ; Gastroenterology & Hepatology ; Health risk assessment ; Life Sciences & Biomedicine ; Liver diseases ; Longitudinal studies ; Population studies ; Population-based studies ; Science & Technology ; Ultrasound ; Women</subject><ispartof>Hepatology research, 2020-01, Vol.50 (1), p.57-66</ispartof><rights>2019 The Japan Society of Hepatology</rights><rights>2019 The Japan Society of Hepatology.</rights><rights>2020 The Japan Society of Hepatology</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>19</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000496416500001</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c4479-4aafa41d5d90ed9a4bdacbced381e8e6530ffe15b392899b74c796d1543042da3</citedby><cites>FETCH-LOGICAL-c4479-4aafa41d5d90ed9a4bdacbced381e8e6530ffe15b392899b74c796d1543042da3</cites><orcidid>0000-0002-8794-0550 ; 0000-0001-7269-1697 ; 0000-0002-8651-4445 ; 0000-0003-0903-1797</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fhepr.13429$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fhepr.13429$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,782,786,1419,27931,27932,28255,28256,45581,45582</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31692179$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Okamura, Takuro</creatorcontrib><creatorcontrib>Hashimoto, Yoshitaka</creatorcontrib><creatorcontrib>Hamaguchi, Masahide</creatorcontrib><creatorcontrib>Obora, Akihiro</creatorcontrib><creatorcontrib>Kojima, Takao</creatorcontrib><creatorcontrib>Fukui, Michiaki</creatorcontrib><title>Creatinine‐to‐bodyweight ratio is a predictor of incident non‐alcoholic fatty liver disease: A population‐based longitudinal study</title><title>Hepatology research</title><addtitle>HEPATOL RES</addtitle><addtitle>Hepatol Res</addtitle><description>Aim
Serum creatinine (Cre) is used as a surrogate marker of muscle mass. We investigated the impact of the Cre‐to‐bodyweight (BW) ratio (Cre/BW) on incident non‐alcoholic fatty liver disease (NAFLD).
Methods
Fatty liver disease was diagnosed by abdominal ultrasonography. In this historical cohort study of 13 728 participants (6397 men and 7331 women), we divided the participants into two groups by sex and into quartiles according to Cre (mg/dL)/BW (kg; Q1–4). We carried out Cox proportional hazard models, adjusting for age, alanine aminotransferase, fasting plasma glucose, systolic blood pressure, alcohol consumption, smoking status, and exercise.
Results
During the 5.1‐year follow up for men and 6.0‐year follow up for women, 2497 participants (1696 men, 801 women) developed NAFLD. The 4000‐days cumulative incidence rates of FLD for men and women were 29.6% and 16.6% in Q1, 28.2% and 10.6% in Q2, 25.5% and 8.8% in Q3, and 22.7% and 7.7% in Q4, respectively. The hazard ratios of incident NAFLD in Q1 (Cre/BW [×100]: men <1.28; women <1.17) were 1.89 (95% confidence interval 1.64–2.17, P < 0.001) in men and 2.96 (2.42–3.62, P < 0.001) in women, compared with Q4 (Cre/BW [×100]: men ≥1.61; women ≥1.51).
Conclusions
A low Cre/BW is associated with an increased risk of NAFLD. Screening Cre/BW can be used to identify individuals who are at high risk of NAFLD.</description><subject>Alanine</subject><subject>Alanine transaminase</subject><subject>Blood pressure</subject><subject>Cohort analysis</subject><subject>cohort study</subject><subject>Creatinine</subject><subject>creatinine‐to‐bodyweight ratio</subject><subject>epidemiology</subject><subject>Fatty liver</subject><subject>fatty liver disease</subject><subject>Gastroenterology & Hepatology</subject><subject>Health risk assessment</subject><subject>Life Sciences & Biomedicine</subject><subject>Liver diseases</subject><subject>Longitudinal studies</subject><subject>Population studies</subject><subject>Population-based studies</subject><subject>Science & Technology</subject><subject>Ultrasound</subject><subject>Women</subject><issn>1386-6346</issn><issn>1872-034X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>AOWDO</sourceid><sourceid>ARHDP</sourceid><recordid>eNqNkU1rFTEUhgdR7Idu_AEScCPK1HzNR7orQ7VCQREFd0MmOdObkpuMScYyO9dd-Rv9JWZ6r124ELNIDsnznvOStyieEXxC8nqzgSmcEMapeFAckrahJWb868Ncs7Yua8brg-IoxmuMSYMpf1wcMFILShpxWNx2AWQyzjj49eNn8nkbvF5uwFxtEgr5ySMTkURTAG1U8gH5ERmnjAaXkPMuK6RVfuOtUWiUKS3Imu8QkDYRZIRTdIYmP8127bXSQ77UyHp3ZdKsjZMWxVwsT4pHo7QRnu7P4-LL2_PP3UV5-eHd--7sslScN6LkUo6SE11pgUELyQct1aBAs5ZAC3XF8DgCqQYmaCvE0HDViFqTijPMqZbsuHi56zsF_22GmPqtiQqslQ78HHvKCK1409I6oy_-Qq_9HLLjleL5x3Hbkky92lEq-BgDjP0UzFaGpSe4XxPq14T6u4Qy_Hzfch62oO_RP5Fk4PUOuIHBj1EZcAruMYwxFzUndZUrvM5u_5_uTLoLofOzS1lK9lJjYfmH5_7i_OOnnfvfyf7DCw</recordid><startdate>202001</startdate><enddate>202001</enddate><creator>Okamura, Takuro</creator><creator>Hashimoto, Yoshitaka</creator><creator>Hamaguchi, Masahide</creator><creator>Obora, Akihiro</creator><creator>Kojima, Takao</creator><creator>Fukui, Michiaki</creator><general>Wiley</general><general>Wiley Subscription Services, Inc</general><scope>17B</scope><scope>AOWDO</scope><scope>ARHDP</scope><scope>BLEPL</scope><scope>DTL</scope><scope>DVR</scope><scope>EGQ</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TM</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-8794-0550</orcidid><orcidid>https://orcid.org/0000-0001-7269-1697</orcidid><orcidid>https://orcid.org/0000-0002-8651-4445</orcidid><orcidid>https://orcid.org/0000-0003-0903-1797</orcidid></search><sort><creationdate>202001</creationdate><title>Creatinine‐to‐bodyweight ratio is a predictor of incident non‐alcoholic fatty liver disease: A population‐based longitudinal study</title><author>Okamura, Takuro ; Hashimoto, Yoshitaka ; Hamaguchi, Masahide ; Obora, Akihiro ; Kojima, Takao ; Fukui, Michiaki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4479-4aafa41d5d90ed9a4bdacbced381e8e6530ffe15b392899b74c796d1543042da3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Alanine</topic><topic>Alanine transaminase</topic><topic>Blood pressure</topic><topic>Cohort analysis</topic><topic>cohort study</topic><topic>Creatinine</topic><topic>creatinine‐to‐bodyweight ratio</topic><topic>epidemiology</topic><topic>Fatty liver</topic><topic>fatty liver disease</topic><topic>Gastroenterology & Hepatology</topic><topic>Health risk assessment</topic><topic>Life Sciences & Biomedicine</topic><topic>Liver diseases</topic><topic>Longitudinal studies</topic><topic>Population studies</topic><topic>Population-based studies</topic><topic>Science & Technology</topic><topic>Ultrasound</topic><topic>Women</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Okamura, Takuro</creatorcontrib><creatorcontrib>Hashimoto, Yoshitaka</creatorcontrib><creatorcontrib>Hamaguchi, Masahide</creatorcontrib><creatorcontrib>Obora, Akihiro</creatorcontrib><creatorcontrib>Kojima, Takao</creatorcontrib><creatorcontrib>Fukui, Michiaki</creatorcontrib><collection>Web of Knowledge</collection><collection>Web of Science - Science Citation Index Expanded - 2020</collection><collection>Web of Science - Social Sciences Citation Index – 2020</collection><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>Social Sciences Citation Index</collection><collection>Web of Science Primary (SCIE, SSCI & AHCI)</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Hepatology research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Okamura, Takuro</au><au>Hashimoto, Yoshitaka</au><au>Hamaguchi, Masahide</au><au>Obora, Akihiro</au><au>Kojima, Takao</au><au>Fukui, Michiaki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Creatinine‐to‐bodyweight ratio is a predictor of incident non‐alcoholic fatty liver disease: A population‐based longitudinal study</atitle><jtitle>Hepatology research</jtitle><stitle>HEPATOL RES</stitle><addtitle>Hepatol Res</addtitle><date>2020-01</date><risdate>2020</risdate><volume>50</volume><issue>1</issue><spage>57</spage><epage>66</epage><pages>57-66</pages><issn>1386-6346</issn><eissn>1872-034X</eissn><abstract>Aim
Serum creatinine (Cre) is used as a surrogate marker of muscle mass. We investigated the impact of the Cre‐to‐bodyweight (BW) ratio (Cre/BW) on incident non‐alcoholic fatty liver disease (NAFLD).
Methods
Fatty liver disease was diagnosed by abdominal ultrasonography. In this historical cohort study of 13 728 participants (6397 men and 7331 women), we divided the participants into two groups by sex and into quartiles according to Cre (mg/dL)/BW (kg; Q1–4). We carried out Cox proportional hazard models, adjusting for age, alanine aminotransferase, fasting plasma glucose, systolic blood pressure, alcohol consumption, smoking status, and exercise.
Results
During the 5.1‐year follow up for men and 6.0‐year follow up for women, 2497 participants (1696 men, 801 women) developed NAFLD. The 4000‐days cumulative incidence rates of FLD for men and women were 29.6% and 16.6% in Q1, 28.2% and 10.6% in Q2, 25.5% and 8.8% in Q3, and 22.7% and 7.7% in Q4, respectively. The hazard ratios of incident NAFLD in Q1 (Cre/BW [×100]: men <1.28; women <1.17) were 1.89 (95% confidence interval 1.64–2.17, P < 0.001) in men and 2.96 (2.42–3.62, P < 0.001) in women, compared with Q4 (Cre/BW [×100]: men ≥1.61; women ≥1.51).
Conclusions
A low Cre/BW is associated with an increased risk of NAFLD. Screening Cre/BW can be used to identify individuals who are at high risk of NAFLD.</abstract><cop>HOBOKEN</cop><pub>Wiley</pub><pmid>31692179</pmid><doi>10.1111/hepr.13429</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-8794-0550</orcidid><orcidid>https://orcid.org/0000-0001-7269-1697</orcidid><orcidid>https://orcid.org/0000-0002-8651-4445</orcidid><orcidid>https://orcid.org/0000-0003-0903-1797</orcidid></addata></record> |
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| subjects | Alanine Alanine transaminase Blood pressure Cohort analysis cohort study Creatinine creatinine‐to‐bodyweight ratio epidemiology Fatty liver fatty liver disease Gastroenterology & Hepatology Health risk assessment Life Sciences & Biomedicine Liver diseases Longitudinal studies Population studies Population-based studies Science & Technology Ultrasound Women |
| title | Creatinine‐to‐bodyweight ratio is a predictor of incident non‐alcoholic fatty liver disease: A population‐based longitudinal study |
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