Cardiovascular Disease, Aging, and Clonal Hematopoiesis

Traditional risk factors are incompletely predictive of cardiovascular disease development, a leading cause of death in the elderly. Recent epidemiological studies have shown that human aging is associated with an increased frequency of somatic mutations in the hematopoietic system, which provide a...

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Veröffentlicht in:	Annual review of pathology 2020-01, Vol.15 (1), p.419-438
Hauptverfasser:	Evans, Megan A, Sano, Soichi, Walsh, Kenneth
Format:	Artikel
Sprache:	eng
Schlagworte:	age-related clonal hematopoiesis Aged Aged, 80 and over Aging - genetics Aging - physiology ARCH Cardiovascular Diseases - epidemiology Cardiovascular Diseases - etiology Cells, Cultured CHIP Clonal Evolution - physiology clonal hematopoiesis of indeterminate potential DNMT3A Hematopoiesis - genetics Hematopoiesis - physiology Humans IL-1β Incidence Mutation - physiology Risk Factors somatic mutations TET2
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