CD27 + CD38 hi B Cell Frequency During Remission Predicts Relapsing Disease in Granulomatosis With Polyangiitis Patients

CD27 + CD38 hi B Cell Frequency During Remission Predicts Relapsing Disease in Granulomatosis With Polyangiitis Patients

Granulomatosis with polyangiitis (GPA) patients are prone to disease relapses. We aimed to determine whether GPA patients at risk for relapse can be identified by differences in B cell subset frequencies. Eighty-five GPA patients were monitored for a median period of 3.1 years (range: 0.1-6.3). Circ...

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Veröffentlicht in:Frontiers in immunology 2019, Vol.10, p.2221
Hauptverfasser: von Borstel, Anouk, Land, Judith, Abdulahad, Wayel H, Rutgers, Abraham, Stegeman, Coen A, Diepstra, Arjan, Heeringa, Peter, Sanders, Jan Stephan
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container_title Frontiers in immunology
container_volume 10
creator von Borstel, Anouk
Land, Judith
Abdulahad, Wayel H
Rutgers, Abraham
Stegeman, Coen A
Diepstra, Arjan
Heeringa, Peter
Sanders, Jan Stephan
description Granulomatosis with polyangiitis (GPA) patients are prone to disease relapses. We aimed to determine whether GPA patients at risk for relapse can be identified by differences in B cell subset frequencies. Eighty-five GPA patients were monitored for a median period of 3.1 years (range: 0.1-6.3). Circulating B cell subset frequencies were analyzed by flow cytometry determining the expression of CD19, CD38, and CD27. B cell subset frequencies at the time of inclusion of future-relapsing (F-R) and non-relapsing (N-R) patients were compared and related to relapse-free survival. Additionally, CD27 CD38 B cells were assessed in urine and kidney biopsies from active anti-neutrophil cytoplasmic autoantibody-associated vasculitides (AAV) patients with renal involvement. Within 1.6 years, 30% of patients experienced a relapse. The CD27 CD38 B cell frequency at the time of inclusion was increased in F-R (median: 2.39%) compared to N-R patients (median: 1.03%; = 0.0025) and a trend was found compared with the HCs (median: 1.33%; = 0.08). This increased CD27 CD38 B cell frequency at inclusion was correlated to decreased relapse-free survival in GPA patients. In addition, 74.7% of patients with an increased CD27 CD38 B cell frequency (≥2.39%) relapsed during follow-up compared to 19.7% of patients with a CD27 CD38 B cell frequency of
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We aimed to determine whether GPA patients at risk for relapse can be identified by differences in B cell subset frequencies. Eighty-five GPA patients were monitored for a median period of 3.1 years (range: 0.1-6.3). Circulating B cell subset frequencies were analyzed by flow cytometry determining the expression of CD19, CD38, and CD27. B cell subset frequencies at the time of inclusion of future-relapsing (F-R) and non-relapsing (N-R) patients were compared and related to relapse-free survival. Additionally, CD27 CD38 B cells were assessed in urine and kidney biopsies from active anti-neutrophil cytoplasmic autoantibody-associated vasculitides (AAV) patients with renal involvement. Within 1.6 years, 30% of patients experienced a relapse. The CD27 CD38 B cell frequency at the time of inclusion was increased in F-R (median: 2.39%) compared to N-R patients (median: 1.03%; = 0.0025) and a trend was found compared with the HCs (median: 1.33%; = 0.08). This increased CD27 CD38 B cell frequency at inclusion was correlated to decreased relapse-free survival in GPA patients. In addition, 74.7% of patients with an increased CD27 CD38 B cell frequency (≥2.39%) relapsed during follow-up compared to 19.7% of patients with a CD27 CD38 B cell frequency of &lt;2.39%. No correlations were found between CD27 CD38 B cells and ANCA levels. CD27 CD38 B cell frequencies were increased in urine compared to the circulation, and were also detected in kidney biopsies, which may indicate CD27 CD38 B cell migration during active disease. 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title CD27 + CD38 hi B Cell Frequency During Remission Predicts Relapsing Disease in Granulomatosis With Polyangiitis Patients
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