N 6 -methyladenosine mRNA marking promotes selective translation of regulons required for human erythropoiesis

Many of the regulatory features governing erythrocyte specification, maturation, and associated disorders remain enigmatic. To identify new regulators of erythropoiesis, we utilize a functional genomic screen for genes affecting expression of the erythroid marker CD235a/GYPA. Among validating hits a...

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Veröffentlicht in:	Nature communications 2019-10, Vol.10 (1), p.4596
Hauptverfasser:	Kuppers, Daniel A, Arora, Sonali, Lim, Yiting, Lim, Andrea R, Carter, Lucas M, Corrin, Philip D, Plaisier, Christopher L, Basom, Ryan, Delrow, Jeffrey J, Wang, Shiyan, Hansen He, Housheng, Torok-Storb, Beverly, Hsieh, Andrew C, Paddison, Patrick J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine - analogs & derivatives Adenosine - genetics Antigens, CD34 - genetics Antigens, CD34 - metabolism Bone Marrow Cells - physiology Cell Cycle Proteins - genetics Cell Line, Tumor CRISPR-Cas Systems Erythropoiesis - genetics Gene Expression Regulation Histones - genetics Histones - metabolism Humans Kruppel-Like Transcription Factors - genetics Kruppel-Like Transcription Factors - metabolism Leukemia, Erythroblastic, Acute - genetics Methyltransferases - genetics Promoter Regions, Genetic Protein Biosynthesis Regulon RNA Splicing Factors - genetics RNA, Messenger - genetics RNA, Messenger - metabolism
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