Cholesterol depletion sensitizes gallbladder cancer to cisplatin by impairing DNA damage response

Gallbladder cancer (GBC) is the common malignancy of the bile tract system with extremely poor clinical outcomes, owing to its metastatic property and intrinsic resistance to the first-line drugs. Although it is well-established that cholesterol abnormity contributes to gallstone formation, a leadin...

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Veröffentlicht in:	Cell cycle (Georgetown, Tex.) Tex.), 2019-12, Vol.18 (23), p.3337-3350
Hauptverfasser:	Zhang, Yonglong, Liu, Yanfeng, Duan, Jinlin, Wang, Hui, Zhang, Yuchen, Qiao, Ke, Wang, Jian
Format:	Artikel
Sprache:	eng
Schlagworte:	Cholesterol DNA Damage response gallbladder cancer Research Paper statins the mevalonate pathway
Online-Zugang:	Volltext
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